STRINGSTRING
LHX2 LHX2 LHX3 LHX3 SDF4 SDF4 TLX3 TLX3 LMX1A LMX1A LEUTX LEUTX DLX1 DLX1 FOXN4 FOXN4 BHLHE23 BHLHE23 LHX5 LHX5 NEUROD1 NEUROD1 VAX1 VAX1 SIM1 SIM1 MYT1L MYT1L SIX6 SIX6 PTF1A PTF1A OTP OTP CALB2 CALB2 ISL1 ISL1 LHX6 LHX6 OTX2 OTX2 ONECUT1 ONECUT1 POU4F1 POU4F1 OLIG2 OLIG2 ASCL1 ASCL1 PVALB PVALB VSX2 VSX2 SOX1 SOX1 PRDM8 PRDM8 POU6F2 POU6F2 DLX2 DLX2 BHLHE22 BHLHE22 GAD1 GAD1 LMX1B LMX1B FGF13 FGF13 SLC32A1 SLC32A1 FOXG1 FOXG1 NKX2-2 NKX2-2 NKX2-1 NKX2-1 SLC17A6 SLC17A6 VSX1 VSX1 SLC6A5 SLC6A5 CALB1 CALB1 BARHL2 BARHL2 NEUROG1 NEUROG1 SIX3 SIX3 POU4F2 POU4F2 ATOH7 ATOH7 PAX6 PAX6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LHX2LIM homeodomain. (400 aa)
LHX3LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. (395 aa)
SDF445 kDa calcium-binding protein; May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment; Belongs to the CREC family. (356 aa)
TLX3T-cell leukemia homeobox protein 3; Seems to be involved in the development of cranial sensory innervation from peripheral ganglia. (296 aa)
LMX1AUncharacterized protein. (380 aa)
LEUTXHomeobox domain-containing protein. (403 aa)
DLX1Homeodomain transcription factor DLX1. (255 aa)
FOXN4Forkhead box N4. (513 aa)
BHLHE23BHLH transcription factor neuroAB. (220 aa)
LHX5LIM homeobox protein 5. (402 aa)
NEUROD1Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
VAX1Ventral anterior homeobox 1; Transcription factor that plays a role in establishing dorsal-ventral polarity in the neural retina. (325 aa)
SIM1SIM bHLH transcription factor 1. (766 aa)
MYT1LMyelin transcription factor 1 like. (1190 aa)
SIX6Homeobox protein SIX6; May be involved in eye development. Belongs to the SIX/Sine oculis homeobox family. (447 aa)
PTF1APancreas associated transcription factor 1a. (275 aa)
OTPOrthopedia homeobox. (325 aa)
CALB2Calretinin; Calretinin is a calcium-binding protein which is abundant in auditory neurons. (311 aa)
ISL1Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
LHX6LIM homeobox 6. (380 aa)
OTX2Homeodomain transcription factor. (289 aa)
ONECUT1One cut domain family member. (450 aa)
POU4F1POU domain, class 4, transcription factor 1; Multifunctional transcription factor with different regions mediating its different effects. Acts by binding (via its C-terminal domain) to sequences related to the consensus octamer motif 5'- ATGCAAAT-3' in the regulatory regions of its target genes. Regulates the expression of specific genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor; Belongs to the POU transcription factor [...] (389 aa)
OLIG2Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
ASCL1BHLH domain-containing protein. (219 aa)
PVALBParvalbumin, muscle; In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions (By similarity); Belongs to the parvalbumin family. (134 aa)
VSX2Visual system homeobox 2; Acts as a transcriptional regulator (By similarity). Plays a significant role in the specification and morphogenesis of the sensory retina (By similarity). Mediates differentiation of V2a interneurons by repression of motor neuron gene transcription, via competitively binding to response elements that are activated by the ISL1-LHX3 complex. May also participate in the development of the cells of the inner nuclear layer, particularly bipolar cells (By similarity); Belongs to the paired homeobox family. (377 aa)
SOX1Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa)
PRDM8PR/SET domain 8. (336 aa)
POU6F2Uncharacterized protein. (166 aa)
DLX2Distal-less homeobox 2. (253 aa)
BHLHE22Class E basic helix-loop-helix protein 22; May act as a transcriptional repressor. (309 aa)
GAD1Glutamate decarboxylase 67. (590 aa)
LMX1BLIM/homeobox protein LMX-1.2; Specifies dorsal cell fate during limb development. (400 aa)
FGF13Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (255 aa)
SLC32A1Solute carrier family 32 member 1. (521 aa)
FOXG1Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
NKX2-2Homeobox domain-containing protein. (272 aa)
NKX2-1Homeobox domain-containing protein. (345 aa)
SLC17A6MFS domain-containing protein. (585 aa)
VSX1Visual system homeobox 1; Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity). Dispensable in early retinal development (By similarity). Belongs to the paired homeobox family. (349 aa)
SLC6A5Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (794 aa)
CALB1Calbindin; Buffers cytosolic calcium. May stimulate a membrane Ca(2+)- ATPase and a 3',5'-cyclic nucleotide phosphodiesterase. (262 aa)
BARHL2BarH like homeobox 2. (369 aa)
NEUROG1Neurogenin 1. (179 aa)
SIX3Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa)
POU4F2POU domain protein. (418 aa)
ATOH7Protein atonal homolog 7; Transcription factor involved in the differentiation of retinal ganglion cells. During retinal neurogenesis, activates its own transcription, as well as the transcription of CHRNB3 and BRN3. (151 aa)
PAX6Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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