16 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LHX3	LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2. (395 aa)
	LMX1A	Uncharacterized protein. (380 aa)
	DLX1	Homeodomain transcription factor DLX1. (255 aa)
	NEUROD1	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'. (357 aa)
	MYT1L	Myelin transcription factor 1 like. (1190 aa)
	ISL1	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...] (349 aa)
	OTX2	Homeodomain transcription factor. (289 aa)
	OLIG2	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord. (298 aa)
	ASCL1	BHLH domain-containing protein. (219 aa)
	SOX1	Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation. (373 aa)
	DLX2	Distal-less homeobox 2. (253 aa)
	FOXG1	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes. (451 aa)
	NKX2-2	Homeobox domain-containing protein. (272 aa)
	NEUROG1	Neurogenin 1. (179 aa)
	SIX3	Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...] (314 aa)
	PAX6	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development. (500 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASCL1	DLX1	ENSGALP00000047577	ENSGALP00000006636	BHLH domain-containing protein.	Homeodomain transcription factor DLX1.	0.796
ASCL1	DLX2	ENSGALP00000047577	ENSGALP00000052409	BHLH domain-containing protein.	Distal-less homeobox 2.	0.907
ASCL1	FOXG1	ENSGALP00000047577	ENSGALP00000054672	BHLH domain-containing protein.	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	0.650
ASCL1	ISL1	ENSGALP00000047577	ENSGALP00000043151	BHLH domain-containing protein.	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	0.782
ASCL1	LHX3	ENSGALP00000047577	ENSGALP00000002660	BHLH domain-containing protein.	LIM/homeobox protein Lhx3; Transcriptional factor that defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LIM-1, ISL-1 and ISL-2.	0.592
ASCL1	LMX1A	ENSGALP00000047577	ENSGALP00000005401	BHLH domain-containing protein.	Uncharacterized protein.	0.728
ASCL1	MYT1L	ENSGALP00000047577	ENSGALP00000026378	BHLH domain-containing protein.	Myelin transcription factor 1 like.	0.897
ASCL1	NEUROD1	ENSGALP00000047577	ENSGALP00000014468	BHLH domain-containing protein.	Neurogenic differentiation factor 1; Acts as a transcriptional activator. Mediates transcriptional activation by binding to E box-containing promoter. Acts as a differentiation factor during neurogenesis. Induces photoreceptor cell overproduction in vivo and de novo generation in vitro. May play a role in photoreceptor cell production. Binds DNA on E-box consensus sequence 5'-CANNTG-3'.	0.484
ASCL1	NEUROG1	ENSGALP00000047577	ENSGALP00000057908	BHLH domain-containing protein.	Neurogenin 1.	0.872
ASCL1	NKX2-2	ENSGALP00000047577	ENSGALP00000054805	BHLH domain-containing protein.	Homeobox domain-containing protein.	0.830
ASCL1	OLIG2	ENSGALP00000047577	ENSGALP00000047462	BHLH domain-containing protein.	Oligodendrocyte transcription factor 2; Required for oligodendrocyte and motor neuron specification in the spinal cord.	0.857
ASCL1	OTX2	ENSGALP00000047577	ENSGALP00000045234	BHLH domain-containing protein.	Homeodomain transcription factor.	0.712
ASCL1	PAX6	ENSGALP00000047577	ENSGALP00000070449	BHLH domain-containing protein.	Paired box protein Pax-6; May be a transcription factor with important functions in eye and nasal development.	0.854
ASCL1	SIX3	ENSGALP00000047577	ENSGALP00000058342	BHLH domain-containing protein.	Homeobox protein SIX3; Transcriptional regulator which can act as both a transcriptional repressor and activator by binding a ATTA homeodomain core recognition sequence on these target genes. During forebrain development represses WNT1 expression allowing zona limitans intrathalamica formation and thereby ensuring proper anterio-posterior patterning of the diencephalon and formation of the rostral diencephalon. Acts as a direct upstream activator of SHH expression in the rostral diencephalon ventral midline and that in turn SHH maintains its expression. In addition, Six3 activity is re [...]	0.579
ASCL1	SOX1	ENSGALP00000047577	ENSGALP00000050087	BHLH domain-containing protein.	Transcription factor SOX-1; Transcriptional activator. May function as a switch in neuronal development. Keeps neural cells undifferentiated by counteracting the activity of proneural protein and suppresses neuronal differentiation.	0.519
DLX1	ASCL1	ENSGALP00000006636	ENSGALP00000047577	Homeodomain transcription factor DLX1.	BHLH domain-containing protein.	0.796
DLX1	DLX2	ENSGALP00000006636	ENSGALP00000052409	Homeodomain transcription factor DLX1.	Distal-less homeobox 2.	0.764
DLX1	FOXG1	ENSGALP00000006636	ENSGALP00000054672	Homeodomain transcription factor DLX1.	Forkhead box protein G1; May determine the nasotemporal axis of the retina, and consequently specify the topographical projection of the retinal ganglion-cell axons to the tectum by controlling expression of their target genes.	0.647
DLX1	ISL1	ENSGALP00000006636	ENSGALP00000043151	Homeodomain transcription factor DLX1.	Insulin gene enhancer protein ISL-1; Acts as a transcriptional regulator. Recognizes and binds to the consensus octamer binding site 5'-ATAATTAA- 3' in promoter of target genes. Plays a fundamental role in the gene regulatory network essential for retinal ganglion cell (RGC) differentiation. Binds to insulin gene enhancer sequences (By similarity). Defines subclasses of motoneurons that segregate into columns in the spinal cord and select distinct axon pathways. Acts in conjunction with LHX1, LHX3 and ISL2. Binds to insulin gene enhancer sequences (By similarity). Essential for heart d [...]	0.551
DLX1	MYT1L	ENSGALP00000006636	ENSGALP00000026378	Homeodomain transcription factor DLX1.	Myelin transcription factor 1 like.	0.633