(12 nodes) Amyloid precursor protein catabolic process, and Amyloid A4 network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	APLP2	BPTI/Kunitz inhibitor domain-containing protein. (753 aa)
	APH1B	Uncharacterized protein. (256 aa)
	ADAM10	Uncharacterized protein. (749 aa)
	NCSTN	Ncstrn_small domain-containing protein. (717 aa)
	TNFRSF21	Uncharacterized protein. (651 aa)
	APP	BPTI/Kunitz inhibitor domain-containing protein. (751 aa)
	BACE1	Beta-secretase 1; Belongs to the peptidase A1 family. (497 aa)
	PSEN2	Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...] (455 aa)
	APH1A	Aph-1 homolog A, gamma-secretase subunit. (311 aa)
	PSEN1	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family. (468 aa)
	APBB1	Amyloid beta precursor protein binding family B member 1. (670 aa)
	APBA2	Amyloid beta precursor protein binding family A member 2. (755 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAM10	APH1A	ENSGALP00000006687	ENSGALP00000066058	Uncharacterized protein.	Aph-1 homolog A, gamma-secretase subunit.	0.435
ADAM10	APH1B	ENSGALP00000006687	ENSGALP00000004055	Uncharacterized protein.	Uncharacterized protein.	0.416
ADAM10	APLP2	ENSGALP00000006687	ENSGALP00000001896	Uncharacterized protein.	BPTI/Kunitz inhibitor domain-containing protein.	0.521
ADAM10	APP	ENSGALP00000006687	ENSGALP00000036014	Uncharacterized protein.	BPTI/Kunitz inhibitor domain-containing protein.	0.635
ADAM10	BACE1	ENSGALP00000006687	ENSGALP00000055878	Uncharacterized protein.	Beta-secretase 1; Belongs to the peptidase A1 family.	0.785
ADAM10	NCSTN	ENSGALP00000006687	ENSGALP00000014876	Uncharacterized protein.	Ncstrn_small domain-containing protein.	0.860
ADAM10	PSEN1	ENSGALP00000006687	ENSGALP00000069770	Uncharacterized protein.	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.	0.822
ADAM10	PSEN2	ENSGALP00000006687	ENSGALP00000058473	Uncharacterized protein.	Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...]	0.618
APBA2	APBB1	ENSGALP00000072398	ENSGALP00000071078	Amyloid beta precursor protein binding family A member 2.	Amyloid beta precursor protein binding family B member 1.	0.635
APBA2	APLP2	ENSGALP00000072398	ENSGALP00000001896	Amyloid beta precursor protein binding family A member 2.	BPTI/Kunitz inhibitor domain-containing protein.	0.588
APBA2	APP	ENSGALP00000072398	ENSGALP00000036014	Amyloid beta precursor protein binding family A member 2.	BPTI/Kunitz inhibitor domain-containing protein.	0.955
APBB1	APBA2	ENSGALP00000071078	ENSGALP00000072398	Amyloid beta precursor protein binding family B member 1.	Amyloid beta precursor protein binding family A member 2.	0.635
APBB1	APLP2	ENSGALP00000071078	ENSGALP00000001896	Amyloid beta precursor protein binding family B member 1.	BPTI/Kunitz inhibitor domain-containing protein.	0.541
APBB1	APP	ENSGALP00000071078	ENSGALP00000036014	Amyloid beta precursor protein binding family B member 1.	BPTI/Kunitz inhibitor domain-containing protein.	0.804
APH1A	ADAM10	ENSGALP00000066058	ENSGALP00000006687	Aph-1 homolog A, gamma-secretase subunit.	Uncharacterized protein.	0.435
APH1A	APH1B	ENSGALP00000066058	ENSGALP00000004055	Aph-1 homolog A, gamma-secretase subunit.	Uncharacterized protein.	0.905
APH1A	APP	ENSGALP00000066058	ENSGALP00000036014	Aph-1 homolog A, gamma-secretase subunit.	BPTI/Kunitz inhibitor domain-containing protein.	0.541
APH1A	NCSTN	ENSGALP00000066058	ENSGALP00000014876	Aph-1 homolog A, gamma-secretase subunit.	Ncstrn_small domain-containing protein.	0.996
APH1A	PSEN1	ENSGALP00000066058	ENSGALP00000069770	Aph-1 homolog A, gamma-secretase subunit.	Presenilin-1 CTF subunit; Catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the presence of the other members of the gamma-secretase complex for protease activity. Plays a role in Notch and Wnt signaling cascades and regulation of downstream processes via its role in processing key regulatory proteins. Belongs to the peptidase A22A family.	0.986
APH1A	PSEN2	ENSGALP00000066058	ENSGALP00000058473	Aph-1 homolog A, gamma-secretase subunit.	Presenilin-2 CTF subunit; Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (amyloid- beta precursor protein). Requires the other members of the gamma- secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. May function in the cytoplasmic partitioning of proteins. The holoprotein functions as a calcium-leak channel that allows the passive movement o [...]	0.961