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| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (175 aa) |
| | IL19 | Interleukin 19. (176 aa) |
| | IL12B | Interleukin-12 subunit beta; Belongs to the type I cytokine receptor family. Type 3 subfamily. (315 aa) |
| | CD276 | Uncharacterized protein. (314 aa) |
| | TNFRSF18 | Uncharacterized protein. (258 aa) |
| | STAT3 | Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa) |
| | STAT5A | Signal transducer and activator of transcription. (764 aa) |
| | IL22RA1 | Interleukin 22 receptor subunit alpha 1. (592 aa) |
| | IL17RD | Interleukin-17 receptor D; Feedback inhibitor of fibroblast growth factor mediated Ras- MAPK signaling and ERK activation. May inhibit FGF-induced FGFR1 tyrosine phosphorylation (By similarity). (741 aa) |
| | CD40LG | CD40 ligand, membrane form; Cytokine that acts as a ligand to CD40/TNFRSF5 (By similarity). Costimulates T-cell proliferation and cytokine production (By similarity). Induces the activation of NF-kappa-B (By similarity). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching (By similarity). Belongs to the tumor necrosis factor family. (272 aa) |
| | IL13 | Interleukin-13. (138 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (207 aa) |
| | CTLA4 | Cytotoxic T-lymphocyte-associated protein 4. (205 aa) |
| | CD28 | T-cell-specific surface glycoprotein CD28 homolog; Possibly involved in T-cell activation. (304 aa) |
| | IL12A | Interleukin-12 subunit alpha; Belongs to the IL-6 superfamily. (203 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons (By similarity). (164 aa) |
| | IL22 | Uncharacterized protein. (197 aa) |
| | BATF | Basic leucine zipper ATF-like transcription factor. (286 aa) |
| | JAK1 | Tyrosine-protein kinase. (1150 aa) |
| | IL12RB2 | Uncharacterized protein. (868 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (145 aa) |
| | IL2 | Interleukin; Belongs to the IL-15/IL-21 family. (143 aa) |
| | LOC768614 | Interferon type A3; Has antiviral activities; Belongs to the alpha/beta interferon family. (193 aa) |
| | IL2RB | Fibronectin type-III domain-containing protein. (576 aa) |
| | IRF4 | Interferon regulatory factor 4. (445 aa) |
| | IL7R | Interleukin-7 receptor alpha chain. (460 aa) |
| | IL6ST | Glycoprotein 130. (918 aa) |
| | CD80 | Uncharacterized protein. (316 aa) |
| | IL17F | Uncharacterized protein. (169 aa) |
| | IL17A | Uncharacterized protein. (169 aa) |
| | GZMK | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (262 aa) |
| | IFNGR1 | Uncharacterized protein. (442 aa) |
| | IFNKL1 | Uncharacterized protein. (197 aa) |
| | CD86 | Uncharacterized protein. (319 aa) |
| | CD40 | Uncharacterized protein. (299 aa) |
| | IFNW1 | Interferon type B; Has antiviral activities; Belongs to the alpha/beta interferon family. (203 aa) |
| | IL4 | Interleukin 4. (136 aa) |
| | IL5 | Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (136 aa) |
| | IL3 | Uncharacterized protein. (138 aa) |
| | SOCS3 | Suppressor of cytokine signaling 3; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 is involved in negative regulation of cytokines that signal through the JAK/STAT pathway. Inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp130, LIF, erythropoietin, insulin and leptin receptors (By similarity). Binding to JAK2 inhibits its kinase activity (By similarity). Regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells (By similarity). Regulates IL-6 [...] (209 aa) |
| | LOC769174 | C-type lectin domain-containing protein. (233 aa) |
| | IL17C | Interleukin 17C. (189 aa) |
| | FOXP1 | Forkhead box protein P1; Transcriptional repressor. (686 aa) |
| | STAT1 | Signal transducer and activator of transcription. (755 aa) |
| | ICOSLG | ICOS ligand. (296 aa) |
| | IFNAR2 | Uncharacterized protein. (524 aa) |
| | GNLY | NK-lysin. (140 aa) |
| | RORC | RAR related orphan receptor C. (461 aa) |
| | IL10RB | Uncharacterized protein. (351 aa) |
| | IL13RA2 | Uncharacterized protein. (391 aa) |
| | IL9 | Interleukin-9. (138 aa) |
| | IL7 | Interleukin-7. (146 aa) |
| | IFNL3A | Interferon lambda-3; Cytokine which plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN-stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type-selective action is because of the epithelial cell-specif [...] (186 aa) |
| | PAX5 | Pax-5 protein. (391 aa) |
| | STAT2 | Signal transducer and activator of transcription. (961 aa) |
| | IL17B | Interleukin 17B. (172 aa) |
| | TYK2 | Tyrosine-protein kinase. (1212 aa) |
| | IL4R | Fibronectin type-III domain-containing protein. (996 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (384 aa) |
| | STAT4 | Signal transducer and activator of transcription. (749 aa) |
| | IL10RA | Fibronectin type-III domain-containing protein. (558 aa) |
| | IFNAR1 | Uncharacterized protein. (569 aa) |
| | IFNGR2 | Uncharacterized protein. (334 aa) |
| | KK34 | Uncharacterized protein. (169 aa) |
| | RAG1 | V(D)J recombination-activating protein 1; Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break b [...] (1041 aa) |
| | IL6R | Uncharacterized protein. (445 aa) |
| | IL2RA | Interleukin-2 alpha receptor. (211 aa) |
| | IL13RA1 | Interleukin 13 receptor subunit alpha 1. (424 aa) |
| | RAG2 | V(D)J recombination-activating protein 2; Core component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T- cell receptor genes in developing B and T lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. DNA cleavage by the RAG complex occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the pho [...] (535 aa) |
| | LOC100858506 | Interferon alpha. (193 aa) |
| | LAG3 | Lymphocyte activating 3. (504 aa) |
| | IL12RB1 | Fibronectin type-III domain-containing protein. (591 aa) |
| | LITAF | Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog; Plays a role in endosomal protein trafficking and in targeting proteins for lysosomal degradation. May also contribute to the regulation of gene expression in the nucleus. Binds DNA (in vitro) and may play a synergistic role in the nucleus in regulating the expression of numerous cytokines. (148 aa) |
| | LOC100859414 | Uncharacterized protein. (193 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response (By similarity). Belongs to the IL-6 superfamily. (307 aa) |
| | IL20RA | Interleukin 20 receptor subunit alpha. (547 aa) |
| | IFNLR1 | Interferon lambda receptor 1; The IFNLR1/IL10RB dimer is a receptor for the cytokine ligands IFNL2 and IFNL3 and mediates their antiviral activity. The ligand/receptor complex stimulate the activation of the JAK/STAT signaling pathway leading to the expression of IFN-stimulated genes (ISG), which contribute to the antiviral state. Determines the cell type specificity of the lambda interferon action. Shows a more restricted pattern of expression in the epithelial tissues thereby limiting responses to lambda interferons primarily to epithelial cells of the respiratory, gastrointestinal, [...] (567 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (187 aa) |
| | LOC100858177 | Interferon type A1/A2; Has antiviral activities. (193 aa) |
| | IKZF1 | DNA-binding protein Ikaros; Binds and activates the enhancer (delta-A element) of the CD3-delta gene. Functions in the specification and the maturation of the T-lymphocyte. Also interacts with a critical control element in the TDT (terminal deoxynucleotidyltransferase) promoter as well as with the promoters for other genes expressed during early stages of B- and T- cell development. Function is isoform-specific and is modulated by dominant-negative inactive isoforms (By similarity). (508 aa) |
| | LOC776018 | Uncharacterized protein. (193 aa) |
| | TBX21 | T-box transcription factor 21. (580 aa) |
| | IL17RA | SEFIR domain-containing protein. (978 aa) |
| | ENSGALP00000071126 | IL17_R_N domain-containing protein. (232 aa) |
| | IL22RA2 | Interleukin 22 receptor subunit alpha 2. (239 aa) |
| | CSF2 | Uncharacterized protein. (144 aa) |
| | IL21R | Uncharacterized protein. (616 aa) |
| | CD8A-3 | Ig-like domain-containing protein. (318 aa) |
| | TNFRSF4 | Uncharacterized protein. (287 aa) |
| | LOC100858762 | Uncharacterized protein. (193 aa) |
| | TNFRSF9 | TNF receptor superfamily member 9. (269 aa) |
| | LOC112530959 | STAT_int domain-containing protein. (392 aa) |
| | PRDM1 | PR/SET domain 1. (789 aa) |
| | GZMA | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (276 aa) |
| | IL9R | Fibronectin type-III domain-containing protein. (481 aa) |
| | ICOS | IGv domain-containing protein. (232 aa) |
| | STAT6 | SH2 domain-containing protein. (183 aa) |
| | JAK2 | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with cytokine receptors. Following ligand-binding to cell surface receptors, phosphorylates specific tyrosine residues on the cytoplasmic tails of the receptor, creating docking sites for STATs proteins. Subsequently, phosphorylates the STATs proteins once they are recru [...] (1165 aa) |
