STRINGSTRING
SIGIRR SIGIRR TOLLIP TOLLIP LBP LBP TLR4 TLR4 TLR5 TLR5 IRAK4 IRAK4 E1C1A7_CHICK E1C1A7_CHICK TBK1 TBK1 RNF11 RNF11 TAB1 TAB1 TAB2 TAB2 IKBKE IKBKE TLR3 TLR3 CGAS CGAS TAB3 TAB3 TLR1A TLR1A NFKB1 NFKB1 CD180 CD180 TLR2B TLR2B PELI3 PELI3 REL REL NFKBIA NFKBIA TICAM1 TICAM1 NFKB2 NFKB2 MYD88 MYD88 MAP3K7 MAP3K7 TNIP2 TNIP2 TNFAIP3 TNFAIP3 RELA RELA TMEM173 TMEM173 UNC93B1 UNC93B1 TLR2A TLR2A CHUK CHUK IKBKB IKBKB TAX1BP1 TAX1BP1 CD14 CD14 TIRAP TIRAP NFKBIB NFKBIB LY96 LY96 TRAF3 TRAF3 TLR1B TLR1B MAP3K8 MAP3K8 TRAF6 TRAF6 TANK TANK NFKBIE NFKBIE TLR7 TLR7 LY86 LY86 IRAK2 IRAK2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SIGIRRUncharacterized protein. (413 aa)
TOLLIPToll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). (274 aa)
LBPUncharacterized protein. (481 aa)
TLR4Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
TLR5TLR5; Belongs to the Toll-like receptor family. (861 aa)
IRAK4Protein kinase domain-containing protein. (373 aa)
E1C1A7_CHICKProtein kinase domain-containing protein. (116 aa)
TBK1Protein kinase domain-containing protein. (729 aa)
RNF11RING-type domain-containing protein. (154 aa)
TAB1PPM-type phosphatase domain-containing protein. (502 aa)
TAB2TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (697 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (837 aa)
TLR3Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
CGASCyclic GMP-AMP synthase. (294 aa)
TAB3TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
TLR1ATIR domain-containing protein; Belongs to the Toll-like receptor family. (818 aa)
NFKB1Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. (983 aa)
CD180CD180 molecule. (708 aa)
TLR2BToll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
PELI3Uncharacterized protein. (418 aa)
RELProto-oncogene c-Rel; Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferen [...] (598 aa)
NFKBIANF-kappa-B inhibitor alpha; Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. May be involved in regulation of transcriptional responses to NF-kappa-B, including cell adhesion, immune and proinflammatory responses, apoptosis, differentiation and growth. Controlled by sequential serine-phosphorylation, ubiquitination and degradation. Tyrosine-phosphorylation could only lead to dissociation from NF-kappa- B (By similarity). (318 aa)
TICAM1TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (735 aa)
NFKB2Nuclear factor NF-kappa-B p100 subunit; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the indi [...] (913 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7. (643 aa)
TNIP2CCHC NOA-type domain-containing protein. (521 aa)
TNFAIP3TNF alpha induced protein 3. (806 aa)
RELATranscription factor p65; NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain- containing proteins. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites tha [...] (559 aa)
TMEM173Stimulator of interferon genes protein; Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta) (By similarity). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm (By similarity). Acts by binding cyclic dinucleotides: recognizes and binds cyclic di- GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus [...] (379 aa)
UNC93B1Unc-93 homolog B1, TLR signaling regulator. (571 aa)
TLR2AToll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
CHUKInhibitor of nuclear factor kappa-B kinase subunit alpha; Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Phosphorylates 'Ser-10' of histone H3 at NF-kappa-B-regulated promoters during inflammatory responses triggered by cytokines; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily. (724 aa)
IKBKBProtein kinase domain-containing protein. (753 aa)
TAX1BP1Uncharacterized protein. (816 aa)
CD14Uncharacterized protein. (465 aa)
TIRAPTIR domain-containing protein. (231 aa)
NFKBIBNFKB inhibitor beta. (320 aa)
LY96Lymphocyte antigen 96. (155 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (567 aa)
TLR1BToll-like receptor 1 type 2; Belongs to the Toll-like receptor family. (652 aa)
MAP3K8Mitogen-activated protein kinase kinase kinase 8. (487 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
TANKTBD domain-containing protein. (422 aa)
NFKBIENFKB inhibitor epsilon. (363 aa)
TLR7Toll-like receptor 7; Belongs to the Toll-like receptor family. (1059 aa)
LY86Lymphocyte antigen 86; May cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Important for efficient CD180 cell surface expression (By similarity). (160 aa)
IRAK2Protein kinase domain-containing protein. (725 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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