(17 nodes) TRAF6-mediated induction of TAK1 complex within TLR4 complex, and Triacyl lipopeptide binding network (Gallus gallus)

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Your Input:
	TOLLIP	Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity). (274 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	IRAK4	Protein kinase domain-containing protein. (373 aa)
	TAB1	PPM-type phosphatase domain-containing protein. (502 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (697 aa)
	TLR3	Toll-like receptor 3; Belongs to the Toll-like receptor family. (896 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
	TLR1A	TIR domain-containing protein; Belongs to the Toll-like receptor family. (818 aa)
	TLR2B	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (781 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (735 aa)
	MYD88	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (299 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (643 aa)
	TLR2A	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2). (955 aa)
	TIRAP	TIR domain-containing protein. (231 aa)
	TLR1B	Toll-like receptor 1 type 2; Belongs to the Toll-like receptor family. (652 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)
	IRAK2	Protein kinase domain-containing protein. (725 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IRAK2	IRAK4	ENSGALP00000072173	ENSGALP00000015599	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.961
IRAK2	MAP3K7	ENSGALP00000072173	ENSGALP00000043939	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.718
IRAK2	MYD88	ENSGALP00000072173	ENSGALP00000042597	Protein kinase domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.992
IRAK2	TAB1	ENSGALP00000072173	ENSGALP00000019817	Protein kinase domain-containing protein.	PPM-type phosphatase domain-containing protein.	0.787
IRAK2	TAB2	ENSGALP00000072173	ENSGALP00000020155	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.967
IRAK2	TAB3	ENSGALP00000072173	ENSGALP00000026205	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 3.	0.896
IRAK2	TICAM1	ENSGALP00000072173	ENSGALP00000041887	Protein kinase domain-containing protein.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.719
IRAK2	TIRAP	ENSGALP00000072173	ENSGALP00000062118	Protein kinase domain-containing protein.	TIR domain-containing protein.	0.786
IRAK2	TLR1A	ENSGALP00000072173	ENSGALP00000028126	Protein kinase domain-containing protein.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.438
IRAK2	TLR2A	ENSGALP00000072173	ENSGALP00000050968	Protein kinase domain-containing protein.	Toll-like receptor 2 type-1; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). Does not respond to LPS and responds with less ability than TLR2-2 to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.514
IRAK2	TLR2B	ENSGALP00000072173	ENSGALP00000038134	Protein kinase domain-containing protein.	Toll-like receptor 2 type-2; Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Mediates the response to mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2).	0.493
IRAK2	TLR3	ENSGALP00000072173	ENSGALP00000021914	Protein kinase domain-containing protein.	Toll-like receptor 3; Belongs to the Toll-like receptor family.	0.678
IRAK2	TLR4	ENSGALP00000072173	ENSGALP00000011319	Protein kinase domain-containing protein.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.819
IRAK2	TOLLIP	ENSGALP00000072173	ENSGALP00000010809	Protein kinase domain-containing protein.	Toll-interacting protein; Component of the signaling pathway of IL-1 and Toll-like receptors. Inhibits cell activation by microbial products. Connects the ubiquitin pathway to autophagy by functioning as a ubiquitin-ATG8 family adapter and thus mediating autophagic clearance of ubiquitin conjugates. The TOLLIP-dependent selective autophagy pathway plays an important role in clearance of cytotoxic polyQ proteins aggregates (By similarity).	0.943
IRAK2	TRAF6	ENSGALP00000072173	ENSGALP00000068399	Protein kinase domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.999
IRAK4	IRAK2	ENSGALP00000015599	ENSGALP00000072173	Protein kinase domain-containing protein.	Protein kinase domain-containing protein.	0.961
IRAK4	MAP3K7	ENSGALP00000015599	ENSGALP00000043939	Protein kinase domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.926
IRAK4	MYD88	ENSGALP00000015599	ENSGALP00000042597	Protein kinase domain-containing protein.	Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response.	0.999
IRAK4	TAB1	ENSGALP00000015599	ENSGALP00000019817	Protein kinase domain-containing protein.	PPM-type phosphatase domain-containing protein.	0.964
IRAK4	TAB2	ENSGALP00000015599	ENSGALP00000020155	Protein kinase domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.978