(10 nodes) interleukin-1 receptor activity, and Interleukin-1 family network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	IL18	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells. (198 aa)
	IL1RL1	Uncharacterized protein. (532 aa)
	IL1R1	Uncharacterized protein. (554 aa)
	IL1B	Interleukin-1; Belongs to the IL-1 family. (267 aa)
	IL1RL2	Uncharacterized protein. (584 aa)
	NLRP3	Uncharacterized protein. (734 aa)
	CTSB	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Belongs to the peptidase C1 family. (360 aa)
	IL1R2	Interleukin 1 receptor type 2. (412 aa)
	CASP1	Uncharacterized protein; Belongs to the peptidase C14A family. (540 aa)
	IL1RAP	Interleukin 1 receptor accessory protein. (795 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP1	CTSB	ENSGALP00000070056	ENSGALP00000061589	Uncharacterized protein; Belongs to the peptidase C14A family.	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Belongs to the peptidase C1 family.	0.652
CASP1	IL18	ENSGALP00000070056	ENSGALP00000012772	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.998
CASP1	IL1B	ENSGALP00000070056	ENSGALP00000050171	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin-1; Belongs to the IL-1 family.	0.998
CASP1	IL1R1	ENSGALP00000070056	ENSGALP00000045214	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.609
CASP1	IL1R2	ENSGALP00000070056	ENSGALP00000062924	Uncharacterized protein; Belongs to the peptidase C14A family.	Interleukin 1 receptor type 2.	0.435
CASP1	NLRP3	ENSGALP00000070056	ENSGALP00000060325	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.985
CTSB	CASP1	ENSGALP00000061589	ENSGALP00000070056	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Belongs to the peptidase C1 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.652
CTSB	IL18	ENSGALP00000061589	ENSGALP00000012772	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Belongs to the peptidase C1 family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.430
CTSB	IL1B	ENSGALP00000061589	ENSGALP00000050171	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Belongs to the peptidase C1 family.	Interleukin-1; Belongs to the IL-1 family.	0.568
CTSB	NLRP3	ENSGALP00000061589	ENSGALP00000060325	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Belongs to the peptidase C1 family.	Uncharacterized protein.	0.932
IL18	CASP1	ENSGALP00000012772	ENSGALP00000070056	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.998
IL18	CTSB	ENSGALP00000012772	ENSGALP00000061589	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Belongs to the peptidase C1 family.	0.430
IL18	IL1B	ENSGALP00000012772	ENSGALP00000050171	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Interleukin-1; Belongs to the IL-1 family.	0.983
IL18	IL1R1	ENSGALP00000012772	ENSGALP00000045214	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Uncharacterized protein.	0.576
IL18	IL1R2	ENSGALP00000012772	ENSGALP00000062924	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Interleukin 1 receptor type 2.	0.527
IL18	IL1RL1	ENSGALP00000012772	ENSGALP00000029597	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Uncharacterized protein.	0.408
IL18	NLRP3	ENSGALP00000012772	ENSGALP00000060325	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	Uncharacterized protein.	0.780
IL1B	CASP1	ENSGALP00000050171	ENSGALP00000070056	Interleukin-1; Belongs to the IL-1 family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.998
IL1B	CTSB	ENSGALP00000050171	ENSGALP00000061589	Interleukin-1; Belongs to the IL-1 family.	Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis; Belongs to the peptidase C1 family.	0.568
IL1B	IL18	ENSGALP00000050171	ENSGALP00000012772	Interleukin-1; Belongs to the IL-1 family.	Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells.	0.983