STRINGSTRING
DHX58 DHX58 EIF2AK2 EIF2AK2 USP41 USP41 MX1 MX1 RSAD2 RSAD2 IRF7 IRF7 CMPK2 CMPK2 IFIH1 IFIH1 RNASEL RNASEL MAVS MAVS IFIT5 IFIT5 IFNA3 IFNA3 IRF1 IRF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
DHX58Uncharacterized protein. (674 aa)
EIF2AK2Uncharacterized protein. (550 aa)
USP41Ubiquitin carboxyl-terminal hydrolase. (424 aa)
MX1Interferon-induced GTP-binding protein Mx; Does not show activity against influenza virus, VSV, Thogoto virus or Sendai virus. (705 aa)
RSAD2Viperin. (354 aa)
IRF7Interferon regulatory factor 3; Key transcriptional regulator of type I interferon (IFN)- dependent immune responses which plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN- stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. May activate transcription by complex formation with other transcriptional factors, possibly members of the STAT family. Binds specifically to the IFN-stimulated response element (ISRE) but not to the [...] (491 aa)
CMPK2Cytidine/uridine monophosphate kinase 2. (221 aa)
IFIH1Uncharacterized protein. (1102 aa)
RNASELUncharacterized protein. (686 aa)
MAVSCARD_2 domain-containing protein. (641 aa)
IFIT5Uncharacterized protein. (479 aa)
IFNA3Interferon. (193 aa)
IRF1Interferon regulatory factor 1; Specifically binds to the upstream regulatory region of type I IFN and IFN-inducible MHC class I genes (the interferon consensus sequence (ICS)) and activates those genes. Acts as a tumor suppressor (By similarity); Belongs to the IRF family. (414 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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