(21 nodes) Mixed, incl. ACE inhibitor pathway, and Amyloid-beta metabolic process network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	REN	Renin; Belongs to the peptidase A1 family. (423 aa)
	MMEL1	Membrane metalloendopeptidase like 1. (773 aa)
	FURIN	Trans Golgi network protease furin; Belongs to the peptidase S8 family. (789 aa)
	MME	Neprilysin. (750 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (464 aa)
	SLC6A18	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (619 aa)
	PREP	Uncharacterized protein. (842 aa)
	TMPRSS2	Transmembrane serine protease 2; Belongs to the peptidase S1 family. (486 aa)
	ACE2	Angiotensin-converting enzyme. (808 aa)
	ACE	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family. (1281 aa)
	TMEM27	Collectrin domain-containing protein. (226 aa)
	IDE	Insulin degrading enzyme; Belongs to the peptidase M16 family. (964 aa)
	BACE2	Beta-secretase 2; Belongs to the peptidase A1 family. (633 aa)
	TLL2	Metalloendopeptidase. (978 aa)
	THOP1	Thimet oligopeptidase 1. (685 aa)
	DPP4	Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
	APEH	Peptidase_S9 domain-containing protein. (739 aa)
	LRP1	Low-density lipoprotein receptor-related protein 1; Endocytic receptor involved in endocytosis and in phagocytosis of apoptotic cells. Involved in cellular lipid homeostasis. Involved in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha 2-macroglobulin), as well as the local metabolism of complexes between plasminogen activators and their endogenous inhibitors. Acts as an alpha-2-macroglobulin receptor. Belongs to the LDLR family. (4583 aa)
	AGTR1	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system. (359 aa)
	UVS.2L	Metalloendopeptidase. (281 aa)
	AGTR2	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family. (372 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE	ACE2	ENSGALP00000039731	ENSGALP00000026662	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Angiotensin-converting enzyme.	0.605
ACE	AGT	ENSGALP00000039731	ENSGALP00000018089	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Angiotensinogen; Belongs to the serpin family.	0.985
ACE	AGTR1	ENSGALP00000039731	ENSGALP00000057556	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	0.939
ACE	AGTR2	ENSGALP00000039731	ENSGALP00000067208	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.764
ACE	DPP4	ENSGALP00000039731	ENSGALP00000052897	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.720
ACE	FURIN	ENSGALP00000039731	ENSGALP00000013566	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Trans Golgi network protease furin; Belongs to the peptidase S8 family.	0.646
ACE	MME	ENSGALP00000039731	ENSGALP00000016796	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Neprilysin.	0.695
ACE	MMEL1	ENSGALP00000039731	ENSGALP00000001681	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Membrane metalloendopeptidase like 1.	0.722
ACE	PREP	ENSGALP00000039731	ENSGALP00000024803	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Uncharacterized protein.	0.458
ACE	REN	ENSGALP00000039731	ENSGALP00000000756	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Renin; Belongs to the peptidase A1 family.	0.981
ACE	SLC6A18	ENSGALP00000039731	ENSGALP00000021494	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.558
ACE	TMEM27	ENSGALP00000039731	ENSGALP00000042770	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Collectrin domain-containing protein.	0.826
ACE	TMPRSS2	ENSGALP00000039731	ENSGALP00000025956	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	Transmembrane serine protease 2; Belongs to the peptidase S1 family.	0.755
ACE2	ACE	ENSGALP00000026662	ENSGALP00000039731	Angiotensin-converting enzyme.	Angiotensin-converting enzyme; Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin; Belongs to the peptidase M2 family.	0.605
ACE2	AGT	ENSGALP00000026662	ENSGALP00000018089	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.969
ACE2	AGTR1	ENSGALP00000026662	ENSGALP00000057556	Angiotensin-converting enzyme.	Type-1 angiotensin II receptor; Receptor for angiotensin II. Mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system.	0.944
ACE2	AGTR2	ENSGALP00000026662	ENSGALP00000067208	Angiotensin-converting enzyme.	Angiotensin II receptor type 2; Belongs to the G-protein coupled receptor 1 family.	0.630
ACE2	DPP4	ENSGALP00000026662	ENSGALP00000052897	Angiotensin-converting enzyme.	Uncharacterized protein; Belongs to the peptidase S9B family.	0.984
ACE2	FURIN	ENSGALP00000026662	ENSGALP00000013566	Angiotensin-converting enzyme.	Trans Golgi network protease furin; Belongs to the peptidase S8 family.	0.890
ACE2	MME	ENSGALP00000026662	ENSGALP00000016796	Angiotensin-converting enzyme.	Neprilysin.	0.663