STRINGSTRING
CALCOCO2 CALCOCO2 ATG16L1 ATG16L1 ATG12 ATG12 NBR1 NBR1 NRBF2 NRBF2 BECN1 BECN1 GABARAPL2 GABARAPL2 WIPI2 WIPI2 ULK2 ULK2 VMP1 VMP1 ATG4A ATG4A MAP1LC3C MAP1LC3C ATG14 ATG14 GABARAPL1 GABARAPL1 ATG3 ATG3 RB1CC1 RB1CC1 AMBRA1 AMBRA1 ATG10 ATG10 ATG2B ATG2B ATG5 ATG5 ATG7 ATG7 PIK3R4 PIK3R4 MAP1LC3A MAP1LC3A UVRAG UVRAG ULK1 ULK1 SQSTM1 SQSTM1 WIPI1 WIPI1 ATG4C ATG4C ATG101 ATG101 MAP1LC3B MAP1LC3B ATG9A ATG9A ATG9B ATG9B PIK3C3 PIK3C3 ATG4B ATG4B ATG13 ATG13
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CALCOCO2SKICH domain-containing protein. (357 aa)
ATG16L1Autophagy related 16 like 1. (623 aa)
ATG12Ubiquitin-like protein ATG12; Ubiquitin-like protein involved in autophagic vesicle formation; Belongs to the ATG12 family. (146 aa)
NBR1NBR1 autophagy cargo receptor. (928 aa)
NRBF2Uncharacterized protein. (435 aa)
BECN1Beclin-1; Plays a central role in autophagy (By similarity). Acts as core subunit of different PI3K complex forms that mediate formation of phosphatidylinositol 3-phosphate and are believed to play a role in multiple membrane trafficking pathways such as initiation of autophagosomes, maturation of autophagosomes and endocytosis (By similarity). Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2 (By similarity). Belongs to the beclin family. (447 aa)
GABARAPL2GABA type A receptor associated protein like 2. (178 aa)
WIPI2WD repeat domain phosphoinositide-interacting protein 2; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation. Involved in an early step of the formation of preautophagosomal structures. (436 aa)
ULK2Unc-51 like autophagy activating kinase 2. (1001 aa)
VMP1Vacuole membrane protein 1. (406 aa)
ATG4ACysteine protease ATG4A; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE). Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity); Belongs to the peptidase C54 family. (397 aa)
MAP1LC3CMicrotubule associated protein 1 light chain 3 gamma. (142 aa)
ATG14Autophagy related 14. (492 aa)
GABARAPL1GABA type A receptor associated protein like 1. (117 aa)
ATG3Autophagy-related protein 3. (313 aa)
RB1CC1RB1 inducible coiled-coil 1. (1598 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (872 aa)
ATG10Autophagy related 10. (227 aa)
ATG2BAutophagy related 2B. (2077 aa)
ATG5Autophagy protein 5; Involved in autophagic vesicle formation. (288 aa)
ATG7Ubiquitin-like modifier-activating enzyme ATG7; E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria [...] (709 aa)
PIK3R4Phosphoinositide-3-kinase regulatory subunit 4. (1426 aa)
MAP1LC3AMicrotubule associated protein 1 light chain 3 alpha. (121 aa)
UVRAGC2 domain-containing protein. (707 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1081 aa)
SQSTM1Sequestosome 1. (453 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (508 aa)
ATG4CCysteine protease; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy; Belongs to the peptidase C54 family. (484 aa)
ATG101Autophagy related 101. (236 aa)
MAP1LC3BUncharacterized protein. (125 aa)
ATG9AAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (919 aa)
ATG9BAutophagy-related protein 9; Involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a key role in the organization of the preautophagosomal structure/phagophore assembly site (PAS), the nucleating site for formation of the sequestering vesicle. Belongs to the ATG9 family. (771 aa)
PIK3C3Phosphatidylinositol 3-kinase catalytic subunit type 3. (944 aa)
ATG4BCysteine protease ATG4B; Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE). Has also an activity of delipidating enzyme for the PE-conjugated forms (By similarity). (393 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (540 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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