STRINGSTRING
CREB3L3 CREB3L3 CREB3 CREB3 CREB3L1 CREB3L1 CREB1 CREB1 CREB3L2 CREB3L2 ATF2 ATF2 PRKACB PRKACB CREBRF CREBRF CREBBP CREBBP RPS6KA5 RPS6KA5 CREB5 CREB5 CREM CREM
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CREB3L3cAMP responsive element binding protein 3 like 3. (493 aa)
CREB3cAMP responsive element binding protein 3. (390 aa)
CREB3L1cAMP responsive element binding protein 3 like 1. (506 aa)
CREB1cAMP response element-binding protein. (327 aa)
CREB3L2cAMP responsive element binding protein 3 like 2. (520 aa)
ATF2Cyclic AMP-dependent transcription factor ATF-2; Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA- 3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA- 3') (By similarity); Belongs to the bZIP family. ATF subfamily. (486 aa)
PRKACBUncharacterized protein; Belongs to the protein kinase superfamily. (398 aa)
CREBRFCREB3 regulatory factor. (636 aa)
CREBBPCREB binding protein. (2522 aa)
RPS6KA5Ribosomal protein S6 kinase alpha-5; Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and that contributes to gene activation by histone phosphorylation. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Directly represses transcription via phosphorylation of 'Ser-1' of histone H2A. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcrip [...] (803 aa)
CREB5cAMP responsive element binding protein 5. (634 aa)
CREMUncharacterized protein. (294 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.