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CHMP7 CHMP7 SNF8 SNF8 CHMP4B CHMP4B FAM168B FAM168B C17orf75 C17orf75 VPS37B VPS37B CPD CPD TSG101 TSG101 UEVLD UEVLD HGS HGS UBAP1L UBAP1L VPS4B VPS4B CHMP5 CHMP5 TBC1D23 TBC1D23 CHMP2B CHMP2B VPS36 VPS36 CHMP1A CHMP1A UBAP1 UBAP1 KIAA0319L KIAA0319L CHMP6 CHMP6 STAM STAM FAM91A1 FAM91A1 MVB12A MVB12A VPS25 VPS25 RHPN2 RHPN2 VPS4A VPS4A CHMP4C CHMP4C FAM49A FAM49A CHMP2A CHMP2A VPS37C VPS37C PDCD6IP PDCD6IP TMPRSS9 TMPRSS9 CHMP1B CHMP1B STAM2 STAM2 VTA1 VTA1 PTPN23 PTPN23 VPS37D VPS37D CHMP3 CHMP3 VPS37A VPS37A MVB12B MVB12B ENSGALP00000074109 ENSGALP00000074109
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CHMP7Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family. (448 aa)
SNF8Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
CHMP4BCharged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (227 aa)
FAM168BFamily with sequence similarity 168 member B. (195 aa)
C17orf75Chromosome 17 open reading frame 75. (287 aa)
VPS37BVPS37B subunit of ESCRT-I. (283 aa)
CPDCarboxypeptidase D. (1360 aa)
TSG101Uncharacterized protein. (390 aa)
UEVLDUEV domain-containing protein. (479 aa)
HGSHepatocyte growth factor-regulated tyrosine kinase substrate. (759 aa)
UBAP1LUncharacterized protein. (428 aa)
VPS4BUncharacterized protein; Belongs to the AAA ATPase family. (438 aa)
CHMP5Uncharacterized protein. (219 aa)
TBC1D23TBC1 domain family member 23; Putative Rab GTPase-activating protein which plays a role in vesicular trafficking. Involved in endosome-to-Golgi trafficking. Acts as a bridging protein by binding simultaneously to golgins, located at the trans-Golgi, and to the WASH complex, located on endosome-derived vesicles (By similarity). Plays a role in brain development (By similarity). May act as a general inhibitor of innate immunity signaling (By similarity). (679 aa)
CHMP2BCharged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (214 aa)
VPS36Vacuolar protein sorting 36 homolog. (541 aa)
CHMP1AUncharacterized protein. (196 aa)
UBAP1Ubiquitin associated protein 1. (515 aa)
KIAA0319LKIAA0319 like. (1141 aa)
CHMP6Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an accepto [...] (200 aa)
STAMSignal transducing adaptor molecule. (522 aa)
FAM91A1Family with sequence similarity 91 member A1. (843 aa)
MVB12AMultivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity). (267 aa)
VPS25Vacuolar protein sorting 25 homolog. (174 aa)
RHPN2Uncharacterized protein. (532 aa)
VPS4AUncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
CHMP4CUncharacterized protein. (220 aa)
FAM49AProtein FAM49A; Belongs to the FAM49 family. (356 aa)
CHMP2ACharged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (220 aa)
VPS37CVPS37 C-terminal domain-containing protein. (370 aa)
PDCD6IPBRO1 domain-containing protein. (887 aa)
TMPRSS9Transmembrane serine protease 9; Belongs to the peptidase S1 family. (1127 aa)
CHMP1BCharged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. (199 aa)
STAM2Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). (576 aa)
VTA1Vesicle trafficking 1. (391 aa)
PTPN23Uncharacterized protein. (64 aa)
VPS37DVPS37D subunit of ESCRT-I. (358 aa)
CHMP3Uncharacterized protein. (241 aa)
VPS37AVPS37A subunit of ESCRT-I. (395 aa)
MVB12BUncharacterized protein. (332 aa)
ENSGALP00000074109Hr1 domain-containing protein. (124 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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