(27 nodes) ESCRT complex, and Midbody abscission network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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Your Input:
	CHMP7	Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family. (448 aa)
	SNF8	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family. (258 aa)
	CHMP4B	Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (227 aa)
	VPS37B	VPS37B subunit of ESCRT-I. (283 aa)
	TSG101	Uncharacterized protein. (390 aa)
	UEVLD	UEV domain-containing protein. (479 aa)
	HGS	Hepatocyte growth factor-regulated tyrosine kinase substrate. (759 aa)
	VPS4B	Uncharacterized protein; Belongs to the AAA ATPase family. (438 aa)
	CHMP5	Uncharacterized protein. (219 aa)
	CHMP2B	Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (214 aa)
	VPS36	Vacuolar protein sorting 36 homolog. (541 aa)
	CHMP1A	Uncharacterized protein. (196 aa)
	CHMP6	Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an accepto [...] (200 aa)
	STAM	Signal transducing adaptor molecule. (522 aa)
	MVB12A	Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity). (267 aa)
	VPS25	Vacuolar protein sorting 25 homolog. (174 aa)
	VPS4A	Uncharacterized protein; Belongs to the AAA ATPase family. (437 aa)
	CHMP4C	Uncharacterized protein. (220 aa)
	CHMP2A	Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity). (220 aa)
	VPS37C	VPS37 C-terminal domain-containing protein. (370 aa)
	PDCD6IP	BRO1 domain-containing protein. (887 aa)
	CHMP1B	Charged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. (199 aa)
	STAM2	Signal transducing adapter molecule 2; Involved in intracellular signal transduction mediated by EGF. As a protein associated with focal adhesions and actin filaments, it may play a role in EGF receptor-stimulated cytoskeletal reorganization. The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). (576 aa)
	VTA1	Vesicle trafficking 1. (391 aa)
	CHMP3	Uncharacterized protein. (241 aa)
	VPS37A	VPS37A subunit of ESCRT-I. (395 aa)
	MVB12B	Uncharacterized protein. (332 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CHMP1A	CHMP1B	ENSGALP00000033033	ENSGALP00000056089	Uncharacterized protein.	Charged multivesicular body protein 1b; Probable peripherally associated component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids.	0.902
CHMP1A	CHMP2A	ENSGALP00000033033	ENSGALP00000050613	Uncharacterized protein.	Charged multivesicular body protein 2a; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).	0.992
CHMP1A	CHMP2B	ENSGALP00000033033	ENSGALP00000024944	Uncharacterized protein.	Charged multivesicular body protein 2b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).	0.952
CHMP1A	CHMP3	ENSGALP00000033033	ENSGALP00000070780	Uncharacterized protein.	Uncharacterized protein.	0.978
CHMP1A	CHMP4B	ENSGALP00000033033	ENSGALP00000003263	Uncharacterized protein.	Charged multivesicular body protein 4b; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids (By similarity).	0.872
CHMP1A	CHMP4C	ENSGALP00000033033	ENSGALP00000047426	Uncharacterized protein.	Uncharacterized protein.	0.872
CHMP1A	CHMP5	ENSGALP00000033033	ENSGALP00000021459	Uncharacterized protein.	Uncharacterized protein.	0.958
CHMP1A	CHMP6	ENSGALP00000033033	ENSGALP00000041343	Uncharacterized protein.	Charged multivesicular body protein 6; Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In the ESCRT-III complex, it probably serves as an accepto [...]	0.820
CHMP1A	CHMP7	ENSGALP00000033033	ENSGALP00000000556	Uncharacterized protein.	Charged multivesicular body protein 7; ESCRT-III-like protein required to recruit the ESCRT-III complex to the nuclear envelope during late anaphase. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Plays a role in the endosomal sorting pathway; Belongs to the SNF7 family.	0.766
CHMP1A	HGS	ENSGALP00000033033	ENSGALP00000011677	Uncharacterized protein.	Hepatocyte growth factor-regulated tyrosine kinase substrate.	0.495
CHMP1A	MVB12A	ENSGALP00000033033	ENSGALP00000044401	Uncharacterized protein.	Multivesicular body subunit 12A; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (By similarity).	0.606
CHMP1A	MVB12B	ENSGALP00000033033	ENSGALP00000073115	Uncharacterized protein.	Uncharacterized protein.	0.637
CHMP1A	PDCD6IP	ENSGALP00000033033	ENSGALP00000053723	Uncharacterized protein.	BRO1 domain-containing protein.	0.437
CHMP1A	SNF8	ENSGALP00000033033	ENSGALP00000001991	Uncharacterized protein.	Vacuolar-sorting protein SNF8; Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. Belongs to the SNF8 family.	0.737
CHMP1A	STAM	ENSGALP00000033033	ENSGALP00000043582	Uncharacterized protein.	Signal transducing adaptor molecule.	0.616
CHMP1A	TSG101	ENSGALP00000033033	ENSGALP00000010193	Uncharacterized protein.	Uncharacterized protein.	0.734
CHMP1A	UEVLD	ENSGALP00000033033	ENSGALP00000010237	Uncharacterized protein.	UEV domain-containing protein.	0.754
CHMP1A	VPS25	ENSGALP00000033033	ENSGALP00000044578	Uncharacterized protein.	Vacuolar protein sorting 25 homolog.	0.798
CHMP1A	VPS36	ENSGALP00000033033	ENSGALP00000027458	Uncharacterized protein.	Vacuolar protein sorting 36 homolog.	0.756
CHMP1A	VPS37A	ENSGALP00000033033	ENSGALP00000072630	Uncharacterized protein.	VPS37A subunit of ESCRT-I.	0.687