STRINGSTRING
GH GH GNRH1 GNRH1 CRHR1 CRHR1 UTS2 UTS2 GPR37L1 GPR37L1 EDN2 EDN2 EYA3 EYA3 UTS2R-2 UTS2R-2 GALR2 GALR2 AGRP AGRP TSHB-2 TSHB-2 SS2 SS2 OXTR OXTR PRLHRL PRLHRL NMUR2 NMUR2 NPFFR1 NPFFR1 SSTR5 SSTR5 NTSR1 NTSR1 NPY4R NPY4R BRS3 BRS3 UTS2B UTS2B SST SST PROK2 PROK2 SSTR4 SSTR4 GHRL GHRL TRH TRH FEZF1 FEZF1 LHCGR LHCGR FSHR FSHR NMUR1 NMUR1 AVPR2 AVPR2 NPY1R NPY1R LOC417800 LOC417800 EDNRA EDNRA SSTR1 SSTR1 LOC107050394 LOC107050394 TSHR TSHR TACR3 TACR3 NPY NPY BDKRB2 BDKRB2 MBOAT4 MBOAT4 HCRT HCRT NPFFR2 NPFFR2 RHOJ RHOJ FSHB FSHB GALR3 GALR3 ELFN2 ELFN2 SSTR3 SSTR3 PRL PRL EDN1 EDN1 PMCH PMCH MC4R MC4R C3AR1 C3AR1 SPX SPX OPRM1 OPRM1 NMBR NMBR AVP AVP PCSK1 PCSK1 ZNF131 ZNF131 F2R F2R F2RL1 F2RL1 CRHBP CRHBP TBX19 TBX19 NPBWR1 NPBWR1 OPRK1 OPRK1 PENK PENK MRAP2 MRAP2 OGFRL1 OGFRL1 PNOC PNOC MLNR MLNR APLNR APLNR MCHR1 MCHR1 HCRTR2 HCRTR2 PROKR1 PROKR1 NMU NMU BDKRB1 BDKRB1 LEPR LEPR PRLHR PRLHR FAM237A FAM237A GNRHR GNRHR CGNRH-R CGNRH-R NPY7R NPY7R AVPR1B AVPR1B ARL11 ARL11 EDNRB EDNRB OXT OXT NPVF NPVF SSTR2 SSTR2 F2RL2 F2RL2 APELA APELA NPY5R NPY5R GRPR GRPR OPRL1 OPRL1 GHSR GHSR NTS NTS GALR1 GALR1 EEF1AKMT4 EEF1AKMT4 LOC396365 LOC396365 GAL GAL MC3R MC3R ECE1 ECE1 PPY PPY PITX1 PITX1 CCK CCK AVPR1A AVPR1A POU1F1 POU1F1 TRIO TRIO GHR GHR CCKBR CCKBR TRHR TRHR GPR37 GPR37 OPRD1 OPRD1 PIBPPDD4L PIBPPDD4L ECE2 ECE2 MC5R MC5R C3 C3 PRLHR2 PRLHR2 PSAP PSAP NMB NMB CRH CRH C5 C5 UCN3 UCN3 CCKAR CCKAR NPSR1 NPSR1 ANOS1 ANOS1 LOC107054568 LOC107054568 PRSS2 PRSS2 CARTPT CARTPT EDN3 EDN3 CHD7 CHD7 NPFF NPFF PRLH PRLH QRFPR QRFPR TRY1P1L1 TRY1P1L1 NPW NPW PYY PYY KNG1 KNG1 F2RL3 F2RL3 POMC POMC LOC420716 LOC420716 ENSGALP00000063679 ENSGALP00000063679 PLVAP PLVAP NPB NPB GPR25 GPR25 MC2R MC2R C5AR1 C5AR1 FFAR2L FFAR2L CRHR2 CRHR2 LOC112530163 LOC112530163 UTS2R2 UTS2R2 MLN MLN PROK1 PROK1 NPBWR2 NPBWR2 APLN APLN GRP GRP RIMBP3C RIMBP3C NSMF NSMF CGA CGA NPS NPS QRFP QRFP NMS NMS UCN UCN EDNRB2 EDNRB2 NPY2R NPY2R PRLR PRLR CRH2 CRH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GHSomatotropin; Growth hormone plays an important role in growth control. (216 aa)
GNRH1GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; Belongs to the GnRH family. (92 aa)
CRHR1Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. (420 aa)
UTS2Preprourotensin II. (124 aa)
GPR37L1G protein-coupled receptor 37 like 1. (612 aa)
EDN2Endothelin-2. (179 aa)
EYA3Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (B [...] (574 aa)
UTS2R-2Urotensin 2 receptor; Belongs to the G-protein coupled receptor 1 family. (382 aa)
GALR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (371 aa)
AGRPAgouti-related protein. (233 aa)
TSHB-2Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (134 aa)
SS2Somatostatin II. (101 aa)
OXTROxytocin-like receptor. (391 aa)
PRLHRLProlactin-releasing peptide receptor-like protein. (344 aa)
NMUR2Neuromedin U receptor type 2; Belongs to the G-protein coupled receptor 1 family. (395 aa)
NPFFR1Neuropeptide FF receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
SSTR5G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (399 aa)
NPY4RNeuropeptide Y receptor 4; Belongs to the G-protein coupled receptor 1 family. (377 aa)
BRS3Bombesin-like peptide receptor subtype 3.5; Belongs to the G-protein coupled receptor 1 family. (396 aa)
UTS2BUncharacterized protein. (126 aa)
SSTSomatostatin-14; Somatostatin inhibits the release of somatotropin. (116 aa)
PROK2Prokineticin 2. (109 aa)
SSTR4Somatostatin receptor 4; Belongs to the G-protein coupled receptor 1 family. (377 aa)
GHRLPreproghrelin. (116 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
FEZF1FEZ family zinc finger 1. (438 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (728 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (704 aa)
NMUR1Neuromedin U receptor type 1; Belongs to the G-protein coupled receptor 1 family. (438 aa)
AVPR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (370 aa)
NPY1RNeuropeptide Y receptor Y1; Belongs to the G-protein coupled receptor 1 family. (385 aa)
LOC417800Uncharacterized protein. (225 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (421 aa)
SSTR1Somatostatin receptor type 1; Belongs to the G-protein coupled receptor 1 family. (392 aa)
LOC107050394Trypsin I-P38; Belongs to the peptidase S1 family. (248 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa)
TACR3Tachykinin receptor 3; Belongs to the G-protein coupled receptor 1 family. (439 aa)
NPYC-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. (97 aa)
BDKRB2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (391 aa)
MBOAT4Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (424 aa)
HCRTUncharacterized protein. (148 aa)
NPFFR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (422 aa)
RHOJUncharacterized protein. (214 aa)
FSHBFollicle stimulating hormone, beta polypeptide. (131 aa)
GALR3G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (405 aa)
ELFN2Extracellular leucine rich repeat and fibronectin type III domain containing 2. (808 aa)
SSTR3Somatostatin receptor type 3; Belongs to the G-protein coupled receptor 1 family. (402 aa)
PRLProlactin. (229 aa)
EDN1Endothelin 1. (194 aa)
PMCHPMCH. (163 aa)
MC4RG_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
C3AR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (461 aa)
SPXSpexin hormone. (116 aa)
OPRM1Mu-type opioid receptor; Belongs to the G-protein coupled receptor 1 family. (415 aa)
NMBRNeuromedin-B receptor; Belongs to the G-protein coupled receptor 1 family. (388 aa)
AVPVasotocin-neurophysin VT; Vasotocin is an antidiuretic hormone. (161 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
ZNF131Zinc finger protein 131. (617 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (407 aa)
F2RL1G_PROTEIN_RECEP_F1_2 domain-containing protein. (391 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa)
TBX19T-box transcription factor TBX19; May be involved in the initial formation of the chordamesoderm. (397 aa)
NPBWR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (331 aa)
OPRK1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (381 aa)
PENKProenkephalin. (267 aa)
MRAP2Uncharacterized protein. (206 aa)
OGFRL1Opioid growth factor receptor like 1. (652 aa)
PNOCUncharacterized protein. (194 aa)
MLNRMotilin receptor MTL-R/GPR38; Belongs to the G-protein coupled receptor 1 family. (349 aa)
APLNRApelin receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
MCHR1Melanin concentrating hormone receptor 1. (367 aa)
HCRTR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (501 aa)
PROKR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (429 aa)
NMUNeuromedin-U-25; Stimulates uterine smooth muscle contraction and causes selective vasoconstriction; Belongs to the NmU family. (181 aa)
BDKRB1Bradykinin receptor B1. (358 aa)
LEPRUncharacterized protein. (1148 aa)
PRLHRG_PROTEIN_RECEP_F1_2 domain-containing protein. (352 aa)
FAM237AFamily with sequence similarity 237 member A. (182 aa)
GNRHRType 1/III gonadotropin-releasing hormone receptor hexahelical variant. (354 aa)
CGNRH-RG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (373 aa)
NPY7RNeuropeptide Y7 receptor; Belongs to the G-protein coupled receptor 1 family. (385 aa)
AVPR1BG_PROTEIN_RECEP_F1_2 domain-containing protein. (425 aa)
ARL11ADP ribosylation factor like GTPase 11; Belongs to the small GTPase superfamily. Arf family. (189 aa)
EDNRBG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (560 aa)
OXTMesotocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (124 aa)
NPVFGonadotropin-inhibitory hormone. (173 aa)
SSTR2Somatostatin receptor type 2; Belongs to the G-protein coupled receptor 1 family. (371 aa)
F2RL2Coagulation factor II thrombin receptor like 2. (378 aa)
APELAApelin receptor early endogenous ligand. (54 aa)
NPY5RG_PROTEIN_RECEP_F1_2 domain-containing protein. (443 aa)
GRPRG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (387 aa)
OPRL1Opiate receptor-like 1; Belongs to the G-protein coupled receptor 1 family. (368 aa)
GHSRG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (561 aa)
NTSNeurotensin. (164 aa)
GALR1Galanin receptor; Belongs to the G-protein coupled receptor 1 family. (357 aa)
EEF1AKMT4EEF1A lysine methyltransferase 4. (248 aa)
LOC396365Gastrin/cholecystokinin-like peptide; Potent stimulus of gastric acid, but not of pancreatic secretion; Belongs to the gastrin/cholecystokinin family. (105 aa)
GALGalanin variant 1. (141 aa)
MC3RMelanocortin 3 receptor. (325 aa)
ECE1Endothelin converting enzyme-1. (752 aa)
PPYPancreatic hormone; Pancreatic hormone is synthesized in pancreatic islets of Langerhans and acts as a regulator of pancreatic and gastrointestinal functions; Belongs to the NPY family. (80 aa)
PITX1Pituitary homeobox 1; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Acts as a transcriptional activator by binding to promoter sequences with a TAAT/GCC core motif; Belongs to the paired homeobox family. Bicoid subfamily. (311 aa)
CCKCholecystokinin-70; This peptide hormone induces gall bladder contraction and the release of pancreatic enzymes in the gut. Its function in the brain is not clear (By similarity). It also decreases food intake and regulates gastrointestinal physiological processes. (130 aa)
AVPR1AG_PROTEIN_RECEP_F1_2 domain-containing protein. (418 aa)
POU1F1Pituitary-specific positive transcription factor 1; Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- 3'; Belongs to the POU transcription factor family. Class-1 subfamily. (363 aa)
TRIOTrio Rho guanine nucleotide exchange factor. (3076 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. (646 aa)
CCKBRG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (436 aa)
TRHRThyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (395 aa)
GPR37G_PROTEIN_RECEP_F1_2 domain-containing protein. (479 aa)
OPRD1Opioid receptor delta 1; Belongs to the G-protein coupled receptor 1 family. (367 aa)
PIBPPDD4LPhosphoinositide phospholipase C. (1139 aa)
ECE2Uncharacterized protein. (814 aa)
MC5RG_PROTEIN_RECEP_F1_2 domain-containing protein. (325 aa)
C3Uncharacterized protein. (1794 aa)
PRLHR2Prolactin releasing peptide receptor-like protein; Belongs to the G-protein coupled receptor 1 family. (361 aa)
PSAPProsaposin; The lysosomal degradation of sphingolipids takes place by the sequential action of specific hydrolases. Some of these enzymes require specific low-molecular mass, non-enzymic proteins: the sphingolipids activator proteins (coproteins). Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. (538 aa)
NMBUncharacterized protein. (159 aa)
CRHCorticotropin releasing hormone. (167 aa)
C5Complement C5. (1758 aa)
UCN3Urocortin 3. (154 aa)
CCKARCholecystokinin type 1 receptor; Belongs to the G-protein coupled receptor 1 family. (429 aa)
NPSR1Neuropeptide S receptor 1; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (373 aa)
ANOS1Anosmin-1; May be an adhesion-like molecule with anti-protease activity. (675 aa)
LOC107054568Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
PRSS2Trypsin II-P29; Belongs to the peptidase S1 family. (248 aa)
CARTPTCART prepropeptide. (111 aa)
EDN3Endothelin 3. (151 aa)
CHD7Chromodomain-helicase-DNA-binding protein 7; Probable transcription regulator. Maybe involved in the in 45S precursor rRNA production (By similarity). (3009 aa)
NPFFNeuropeptide FF-amide peptide. (105 aa)
PRLHUncharacterized protein. (87 aa)
QRFPROrexigenic neuropeptide QRFP receptor; Belongs to the G-protein coupled receptor 1 family. (430 aa)
TRY1P1L1Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (248 aa)
NPWNeuropeptide W. (139 aa)
PYYPeptide YY-like; This gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action and inhibitis jejunal and colonic mobility. Belongs to the NPY family. (90 aa)
KNG1Kininogen 1. (551 aa)
F2RL3F2R like thrombin or trypsin receptor 3; Belongs to the G-protein coupled receptor 1 family. (386 aa)
POMCUncharacterized protein. (251 aa)
LOC420716Prolactin-releasing peptide. (139 aa)
ENSGALP00000063679G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (388 aa)
PLVAPUncharacterized protein. (415 aa)
NPBNeuropeptide B. (119 aa)
GPR25Apelin receptor 2; Belongs to the G-protein coupled receptor 1 family. (365 aa)
MC2RG_PROTEIN_RECEP_F1_2 domain-containing protein. (357 aa)
C5AR1G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
FFAR2LG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (367 aa)
CRHR2Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (427 aa)
LOC112530163SH2 domain-containing protein. (839 aa)
UTS2R2Urotensin 2 receptor 2; Belongs to the G-protein coupled receptor 1 family. (343 aa)
MLNMotilin; Plays an important role in the regulation of interdigestive gastrointestinal motility and indirectly causes rhythmic contraction of duodenal and colonic smooth muscle; Belongs to the motilin family. (115 aa)
PROK1Prokineticin 1. (99 aa)
NPBWR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (332 aa)
APLNApelin. (78 aa)
GRPGastrin-releasing peptide; Stimulates the release of gastrin and other gastrointestinal hormones (Probable). Stimulates pancreatic protein and fluid secretion, and increases acid secretion from the avian proventriculus. Belongs to the bombesin/neuromedin-B/ranatensin family. (164 aa)
RIMBP3CSH3 domain-containing protein. (262 aa)
NSMFNMDA receptor synaptonuclear signaling and neuronal migration factor. (513 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
NPSNeuropeptide S. (99 aa)
QRFPUncharacterized protein. (122 aa)
NMSNeuromedin S long isoform. (150 aa)
UCNUrocortin. (100 aa)
EDNRB2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (479 aa)
NPY2RNeuropeptide Y receptor type 2; Receptor for neuropeptide Y and peptide YY; Belongs to the G-protein coupled receptor 1 family. (385 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (831 aa)
CRH2Corticotropin-releasing hormone 2. (107 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (22%) [HD]