STRINGSTRING
GH GH GNRH1 GNRH1 CRHR1 CRHR1 EYA3 EYA3 AGRP AGRP TSHB-2 TSHB-2 OXTR OXTR GHRL GHRL TRH TRH LHCGR LHCGR FSHR FSHR AVPR2 AVPR2 LOC417800 LOC417800 TSHR TSHR MBOAT4 MBOAT4 HCRT HCRT FSHB FSHB PRL PRL PMCH PMCH MC4R MC4R AVP AVP PCSK1 PCSK1 CRHBP CRHBP TBX19 TBX19 MRAP2 MRAP2 MCHR1 MCHR1 HCRTR2 HCRTR2 LEPR LEPR FAM237A FAM237A GNRHR GNRHR CGNRH-R CGNRH-R AVPR1B AVPR1B ARL11 ARL11 OXT OXT GHSR GHSR MC3R MC3R PITX1 PITX1 AVPR1A AVPR1A POU1F1 POU1F1 GHR GHR TRHR TRHR PIBPPDD4L PIBPPDD4L MC5R MC5R CRH CRH UCN3 UCN3 CARTPT CARTPT POMC POMC ENSGALP00000063679 ENSGALP00000063679 MC2R MC2R CRHR2 CRHR2 LOC112530163 LOC112530163 CGA CGA UCN UCN PRLR PRLR CRH2 CRH2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GHSomatotropin; Growth hormone plays an important role in growth control. (216 aa)
GNRH1GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; Belongs to the GnRH family. (92 aa)
CRHR1Corticotropin-releasing factor receptor 1; G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. (420 aa)
EYA3Eyes absent homolog 3; Tyrosine phosphatase that specifically dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. May be involved in development of the eye (B [...] (574 aa)
AGRPAgouti-related protein. (233 aa)
TSHB-2Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (134 aa)
OXTROxytocin-like receptor. (391 aa)
GHRLPreproghrelin. (116 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems; Belongs to the TRH family. (260 aa)
LHCGRLutropin-choriogonadotropic hormone receptor; Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase; Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (728 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (704 aa)
AVPR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily. (370 aa)
LOC417800Uncharacterized protein. (225 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (761 aa)
MBOAT4Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (424 aa)
HCRTUncharacterized protein. (148 aa)
FSHBFollicle stimulating hormone, beta polypeptide. (131 aa)
PRLProlactin. (229 aa)
PMCHPMCH. (163 aa)
MC4RG_PROTEIN_RECEP_F1_2 domain-containing protein. (331 aa)
AVPVasotocin-neurophysin VT; Vasotocin is an antidiuretic hormone. (161 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa)
TBX19T-box transcription factor TBX19; May be involved in the initial formation of the chordamesoderm. (397 aa)
MRAP2Uncharacterized protein. (206 aa)
MCHR1Melanin concentrating hormone receptor 1. (367 aa)
HCRTR2G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (501 aa)
LEPRUncharacterized protein. (1148 aa)
FAM237AFamily with sequence similarity 237 member A. (182 aa)
GNRHRType 1/III gonadotropin-releasing hormone receptor hexahelical variant. (354 aa)
CGNRH-RG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (373 aa)
AVPR1BG_PROTEIN_RECEP_F1_2 domain-containing protein. (425 aa)
ARL11ADP ribosylation factor like GTPase 11; Belongs to the small GTPase superfamily. Arf family. (189 aa)
OXTMesotocin/neurophysin I prepropeptide; Belongs to the vasopressin/oxytocin family. (124 aa)
GHSRG_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (561 aa)
MC3RMelanocortin 3 receptor. (325 aa)
PITX1Pituitary homeobox 1; Sequence-specific transcription factor that binds gene promoters and activates their transcription. May play a role in the development of anterior structures, and in particular, the brain and facies and in specifying the identity or structure of hindlimb. Acts as a transcriptional activator by binding to promoter sequences with a TAAT/GCC core motif; Belongs to the paired homeobox family. Bicoid subfamily. (311 aa)
AVPR1AG_PROTEIN_RECEP_F1_2 domain-containing protein. (418 aa)
POU1F1Pituitary-specific positive transcription factor 1; Transcription factor that activates growth hormone and prolactin genes. Specifically binds to the consensus sequence 5'-TAAAT- 3'; Belongs to the POU transcription factor family. Class-1 subfamily. (363 aa)
GHRGrowth hormone-binding protein; Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to, and activates the JAK2/STAT5 pathway; Belongs to the type I cytokine receptor family. Type 1 subfamily. (646 aa)
TRHRThyrotropin-releasing hormone receptor; Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system; Belongs to the G-protein coupled receptor 1 family. (395 aa)
PIBPPDD4LPhosphoinositide phospholipase C. (1139 aa)
MC5RG_PROTEIN_RECEP_F1_2 domain-containing protein. (325 aa)
CRHCorticotropin releasing hormone. (167 aa)
UCN3Urocortin 3. (154 aa)
CARTPTCART prepropeptide. (111 aa)
POMCUncharacterized protein. (251 aa)
ENSGALP00000063679G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (388 aa)
MC2RG_PROTEIN_RECEP_F1_2 domain-containing protein. (357 aa)
CRHR2Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (427 aa)
LOC112530163SH2 domain-containing protein. (839 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
UCNUrocortin. (100 aa)
PRLRProlactin receptor; This is a receptor for the anterior pituitary hormone prolactin; Belongs to the type I cytokine receptor family. Type 1 subfamily. (831 aa)
CRH2Corticotropin-releasing hormone 2. (107 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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