(62 nodes) Mixed, incl. G alpha (z) signalling events, and G-protein beta/gamma-subunit complex binding network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	ADRA1A	Adrenoceptor alpha 1A. (467 aa)
	ADRA1B	Adrenoceptor alpha 1B. (507 aa)
	RGR	G_PROTEIN_RECEP_F1_2 domain-containing protein. (295 aa)
	GNA11	Guanine nucleotide-binding protein G11 alpha-subunit. (359 aa)
	CYSLTR1	Cysteinyl leukotriene receptor 1. (425 aa)
	GNG13	G protein gamma domain-containing protein. (67 aa)
	ARHGEF12	Rho guanine nucleotide exchange factor 12. (1544 aa)
	GNAZ	G protein subunit alpha z. (355 aa)
	HTR2B	Serotonin receptor subtype 2b. (462 aa)
	ADCY9	Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors. (1346 aa)
	DRD2	Dopamine receptor 2 protein transcript variant 1; Belongs to the G-protein coupled receptor 1 family. (437 aa)
	LPAR3	Lysophosphatidic acid receptor 3; Belongs to the G-protein coupled receptor 1 family. (361 aa)
	ADRB1	Adrenoceptor beta 1. (477 aa)
	OPN3	Opsin 3. (395 aa)
	RRH	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (334 aa)
	ADCY2	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1101 aa)
	GNAL	Uncharacterized protein. (379 aa)
	GNA14	Uncharacterized protein. (187 aa)
	GNAQ	Uncharacterized protein. (359 aa)
	GNG10	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	LPAR1	Lysophosphatidic acid receptor 1; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	ADCY3	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1127 aa)
	OPN5	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	HTR2A	5-hydroxytryptamine (Serotonin) receptor 2A. (468 aa)
	ADRB3	G_PROTEIN_RECEP_F1_2 domain-containing protein. (425 aa)
	ADRA2A	Adrenoceptor alpha 2A. (444 aa)
	GNG5	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (68 aa)
	GNG2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (71 aa)
	GNAI1	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...] (354 aa)
	PLCB1	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1219 aa)
	ADCY6-2	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1217 aa)
	GNB5	WD_REPEATS_REGION domain-containing protein. (353 aa)
	ADRB2	Adrenoceptor beta 2. (402 aa)
	GNB3	G protein subunit beta 3. (340 aa)
	TACR1	Substance P receptor; Belongs to the G-protein coupled receptor 1 family. (411 aa)
	LPAR4	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (348 aa)
	PLCB2	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1211 aa)
	GNGT2	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (69 aa)
	RAPGEF4	Rap guanine nucleotide exchange factor 4. (1026 aa)
	ADCY1	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
	ARHGEF11	Rho guanine nucleotide exchange factor 11. (1785 aa)
	GNA13	G protein subunit alpha 13. (377 aa)
	ADRA1D	Adrenoceptor alpha 1D. (511 aa)
	LPAR2	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (362 aa)
	GNG4	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (88 aa)
	TAC1	Tachykinin precursor 1. (114 aa)
	GNB4	G protein subunit beta 4. (340 aa)
	GNAS	Guanine nucleotide-binding protein G(S) subunit alpha XL. (417 aa)
	GCGR	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (532 aa)
	ADCY7	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
	PLCB4	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1210 aa)
	GNA12	G protein subunit alpha 12. (287 aa)
	RAPGEF3	Rap guanine nucleotide exchange factor 3. (1050 aa)
	HTR2C	5-hydroxytryptamine (Serotonin) receptor 2C. (472 aa)
	ENSGALP00000069116	Uncharacterized protein. (59 aa)
	ENSGALP00000069991	Uncharacterized protein. (109 aa)
	LPAR5	Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (370 aa)
	CYSLTR2	Cysteinyl leukotriene receptor 2. (310 aa)
	ADCY6	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1132 aa)
	GNAI2	Guanine nucleotide-binding protein G(i) subunit alpha-2. (460 aa)
	OPN1LW	Red-sensitive opsin; Visual pigments are the light-absorbing molecules that mediate vision. They consist of an apoprotein, opsin, covalently linked to cis-retinal. (362 aa)
	GNG7	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. (390 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCY1	ADCY2	ENSGALP00000054345	ENSGALP00000021289	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.533
ADCY1	ADCY3	ENSGALP00000054345	ENSGALP00000026753	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.900
ADCY1	ADCY6	ENSGALP00000054345	ENSGALP00000072088	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.541
ADCY1	ADCY6-2	ENSGALP00000054345	ENSGALP00000046168	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.533
ADCY1	ADCY7	ENSGALP00000054345	ENSGALP00000067706	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	0.558
ADCY1	ADCY9	ENSGALP00000054345	ENSGALP00000012606	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adenylate cyclase type 9; Adenylyl cyclase that catalyzes the formation of the signaling molecule cAMP in response to activation of G protein-coupled receptors.	0.645
ADCY1	ADRA2A	ENSGALP00000054345	ENSGALP00000038251	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Adrenoceptor alpha 2A.	0.588
ADCY1	GNAI1	ENSGALP00000054345	ENSGALP00000044195	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(i) subunit alpha-1; Guanine nucleotide-binding proteins (G proteins) function as transducers downstream of G protein-coupled receptors (GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numer [...]	0.705
ADCY1	GNAI2	ENSGALP00000054345	ENSGALP00000072608	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(i) subunit alpha-2.	0.705
ADCY1	GNAL	ENSGALP00000054345	ENSGALP00000022345	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Uncharacterized protein.	0.938
ADCY1	GNAS	ENSGALP00000054345	ENSGALP00000066357	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein G(S) subunit alpha XL.	0.939
ADCY1	GNAZ	ENSGALP00000054345	ENSGALP00000010857	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit alpha z.	0.579
ADCY1	GNB3	ENSGALP00000054345	ENSGALP00000048840	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 3.	0.546
ADCY1	GNB4	ENSGALP00000054345	ENSGALP00000065217	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein subunit beta 4.	0.688
ADCY1	GNB5	ENSGALP00000054345	ENSGALP00000048497	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	WD_REPEATS_REGION domain-containing protein.	0.700
ADCY1	GNG10	ENSGALP00000054345	ENSGALP00000025250	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.660
ADCY1	GNG13	ENSGALP00000054345	ENSGALP00000008472	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	G protein gamma domain-containing protein.	0.695
ADCY1	GNG2	ENSGALP00000054345	ENSGALP00000043053	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.679
ADCY1	GNG4	ENSGALP00000054345	ENSGALP00000058741	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.679
ADCY1	GNG5	ENSGALP00000054345	ENSGALP00000042625	Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.658