STRINGSTRING
MYL4 MYL4 MYH1G MYH1G TNNC1 TNNC1 UNC45B UNC45B MYL1 MYL1 MYPN MYPN CSRP3 CSRP3 MYOM3 MYOM3 DUPD1 DUPD1 MYOZ1 MYOZ1 KLHL40 KLHL40 TNNI2 TNNI2 TNNC2 TNNC2 ANKRD2 ANKRD2 CALML4 CALML4 CKMT1B CKMT1B LMOD2 LMOD2 ASB15 ASB15 NRAP NRAP BEST3 BEST3 DES DES TAGLN TAGLN TPM3 TPM3 MYOM2 MYOM2 KLHL34 KLHL34 METTL21EP METTL21EP LMOD3 LMOD3 POPDC2 POPDC2 LSMEM1 LSMEM1 CKMT2 CKMT2 TMEM8C TMEM8C MYL2 MYL2 MUSTN1 MUSTN1 MYH15 MYH15 MYBPC1 MYBPC1 GATM GATM XIRP1 XIRP1 TPM4 TPM4 MYOD1 MYOD1 CALML3 CALML3 MYOG MYOG KLHL33 KLHL33 LMOD1 LMOD1 MYH1D MYH1D MYL3 MYL3 MYF5 MYF5 MYOT MYOT MYH10 MYH10 PAX7 PAX7 ACTBL2 ACTBL2 MYO7L2 MYO7L2 TMEM182 TMEM182 MYH1E MYH1E ASB9 ASB9 MEF2D MEF2D TNNT1 TNNT1 MYH7B MYH7B CNN1 CNN1 MYH11 MYH11 CKB CKB NEBL-2 NEBL-2 MYH7 MYH7 MYH1F MYH1F LRSAM1 LRSAM1 TNNT2 TNNT2 TPM2 TPM2 MYL6 MYL6 ENSGALP00000051466 ENSGALP00000051466 MYL10 MYL10 ACTA1 ACTA1 MYBPC3 MYBPC3 CAPN3 CAPN3 CNN2 CNN2 MYH9 MYH9 ACTN2 ACTN2 NEBL NEBL SYNPO2L SYNPO2L MYOM1 MYOM1 TPM1 TPM1 MYH1A MYH1A PAX3 PAX3 MLIP MLIP MYOZ2 MYOZ2 MYL12B MYL12B CALD1 CALD1 MYL12A MYL12A SMYD1 SMYD1 MYH1B MYH1B MYLK MYLK MYO18B MYO18B ACTC1 ACTC1 CNN3 CNN3 MYL9 MYL9 TNNT3 TNNT3 SMTN SMTN PPP1R3A PPP1R3A NEBL1 NEBL1 MEF2B MEF2B DUSP22AL DUSP22AL MYLPF MYLPF MYBPC2 MYBPC2 MYLK4 MYLK4 MYOZ3 MYOZ3 CORO6 CORO6 ACTA2 ACTA2 DYSF DYSF ENSGALP00000068828 ENSGALP00000068828 MYOCD MYOCD ENSGALP00000069840 ENSGALP00000069840 SMPX SMPX ENSGALP00000070799 ENSGALP00000070799 MYF6 MYF6 MEF2A MEF2A FBXO40 FBXO40 ACTG2 ACTG2 GAMT GAMT TNNI1 TNNI1 ENSGALP00000073668 ENSGALP00000073668 ENSGALP00000073678 ENSGALP00000073678 SCO1 SCO1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MYL4Myosin light chain, embryonic. (185 aa)
MYH1GUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
TNNC1Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (215 aa)
UNC45BUnc-45 myosin chaperone B. (929 aa)
MYL1Myosin light chain 1, skeletal muscle isoform. (192 aa)
MYPNMyopalladin. (991 aa)
CSRP3Uncharacterized protein. (194 aa)
MYOM3Myomesin 3. (1373 aa)
DUPD1Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. (214 aa)
MYOZ1Myozenin 1. (278 aa)
KLHL40Kelch like family member 40. (587 aa)
TNNI2Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (183 aa)
TNNC2Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (163 aa)
ANKRD2Ankyrin repeat domain 2 protein. (334 aa)
CALML4Uncharacterized protein. (153 aa)
CKMT1BCreatine kinase U-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (417 aa)
LMOD2Leiomodin-2; Mediates nucleation of actin filaments and thereby promotes actin polymerization (By similarity). Plays a role in the regulation of actin filament length. Required for normal sarcomere organization in the heart, and for normal heart function (By similarity); Belongs to the tropomodulin family. (552 aa)
ASB15Ankyrin repeat and SOCS box containing 15. (590 aa)
NRAPNebulin related anchoring protein. (1736 aa)
BEST3Bestrophin homolog; Forms chloride channels; Belongs to the bestrophin family. (669 aa)
DESDesmin; Muscle-specific type III intermediate filament essential for proper muscular structure and function. Plays a crucial role in maintaining the structure of sarcomeres, inter-connecting the Z-disks and forming the myofibrils, linking them not only to the sarcolemmal cytoskeleton, but also to the nucleus and mitochondria, thus providing strength for the muscle fiber during activity. In adult striated muscle they form a fibrous network connecting myofibrils to each other and to the plasma membrane from the periphery of the Z-line structures. (464 aa)
TAGLNTransgelin; Actin cross-linking/gelling protein; Belongs to the calponin family. (200 aa)
TPM3Uncharacterized protein; Belongs to the tropomyosin family. (332 aa)
MYOM2M-protein, striated muscle; Is a structural constituent of myofibrillar M-band in striated muscle. (1450 aa)
KLHL34Kelch like family member 34. (595 aa)
METTL21EPUncharacterized protein. (256 aa)
LMOD3Leiomodin 3. (524 aa)
POPDC2Uncharacterized protein. (356 aa)
LSMEM1Leucine rich single-pass membrane protein 1. (158 aa)
CKMT2Creatine kinase S-type, mitochondrial; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (419 aa)
TMEM8CUncharacterized protein. (220 aa)
MYL2Myosin regulatory light chain 2A, cardiac muscle isoform. (202 aa)
MUSTN1Musculoskeletal embryonic nuclear protein 1; May be involved in the development and regeneration of the musculoskeletal system; Belongs to the MUSTANG family. (78 aa)
MYH15Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
MYBPC1Myosin binding protein C, slow type. (1227 aa)
GATMGlycine amidinotransferase, mitochondrial; Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development (By similarity); Belongs to the amidinotransferase family. (422 aa)
XIRP1Xin actin-binding repeat-containing protein 1; Protects actin filaments from depolymerization (By similarity). Involved in cardiac morphogenesis. (2563 aa)
TPM4Tropomyosin 4; Belongs to the tropomyosin family. (284 aa)
MYOD1Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa)
CALML3Calmodulin, striated muscle; Belongs to the calmodulin family. (149 aa)
MYOGMyogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (227 aa)
KLHL33BTB domain-containing protein. (782 aa)
LMOD1Leiomodin 1. (624 aa)
MYH1DMyosin-1B; Muscle contraction. (1940 aa)
MYL3Myosin light chain 1, cardiac muscle. (194 aa)
MYF5Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (258 aa)
MYOTMyotilin. (513 aa)
MYH10Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2016 aa)
PAX7PAX7 protein. (524 aa)
ACTBL2Uncharacterized protein. (377 aa)
MYO7L2Myosin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1743 aa)
TMEM182Transmembrane protein 182. (233 aa)
MYH1EMyosin heavy chain, skeletal muscle, adult; Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. (1939 aa)
ASB9Uncharacterized protein. (294 aa)
MEF2DMADS-box domain-containing protein. (570 aa)
TNNT1Uncharacterized protein. (272 aa)
MYH7BUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
CNN1Calponin-1; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (325 aa)
MYH11Myosin-11; Muscle contraction; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1978 aa)
CKBCreatine kinase B-type; Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa; Belongs to the ATP:guanido phosphotransferase family. (376 aa)
NEBL-2Uncharacterized protein. (334 aa)
MYH7Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1931 aa)
MYH1FUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (728 aa)
TNNT2Troponin T, cardiac muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (302 aa)
TPM2Tropomyosin beta chain; Belongs to the tropomyosin family. (335 aa)
MYL6Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. (275 aa)
ENSGALP00000051466Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (462 aa)
MYL10Myosin regulatory light chain 2B, cardiac muscle isoform. (187 aa)
ACTA1Actin, alpha skeletal muscle. (390 aa)
MYBPC3Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle A bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. May be involved in the early phase of myofibrillogenesis; Belongs to the immunoglobulin superfamily. MyBP family. (1285 aa)
CAPN3Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. (810 aa)
CNN2Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (305 aa)
MYH9Myosin-9; Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping. (1960 aa)
ACTN2Alpha-actinin-2; F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein (By similarity). (923 aa)
NEBLNebulette. (668 aa)
SYNPO2LSynaptopodin 2 like. (1080 aa)
MYOM1Uncharacterized protein. (1671 aa)
TPM1Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (321 aa)
MYH1AUncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1939 aa)
PAX3Paired-box transcription factor protein PAX3. (484 aa)
MLIPUncharacterized protein. (372 aa)
MYOZ2Uncharacterized protein. (263 aa)
MYL12BUncharacterized protein. (172 aa)
CALD1Caldesmon. (524 aa)
MYL12AMyosin regulatory light chain 2, smooth muscle minor isoform; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). (198 aa)
SMYD1Uncharacterized protein. (491 aa)
MYH1BMyosin-1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1944 aa)
MYLKMyosin light chain kinase, smooth muscle, deglutamylated form; Phosphorylates a specific serine in the N-terminus of a myosin light chain, which leads to the formation of calmodulin/MLCK signal transduction complexes which allow selective transduction of calcium signals. (1963 aa)
MYO18BMyosin XVIIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2380 aa)
ACTC1Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
CNN3Calponin; Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. (331 aa)
MYL9Myosin regulatory light chain 2, smooth muscle major isoform; Myosin regulatory subunit that plays an important role in regulation of both smooth muscle and nonmuscle cell contractile activity. Implicated in cytokinesis, receptor capping, and cell locomotion (By similarity). (172 aa)
TNNT3Troponin T, fast skeletal muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (220 aa)
SMTNSmoothelin. (1038 aa)
PPP1R3AProtein phosphatase 1 regulatory subunit 3A. (1088 aa)
NEBL1Uncharacterized protein. (2613 aa)
MEF2BMyocyte enhancer factor 2B. (398 aa)
DUSP22ALDSPc domain-containing protein. (180 aa)
MYLPFMyosin regulatory light chain 2, skeletal muscle isoform. (87 aa)
MYBPC2Myosin-binding protein C, fast-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. (254 aa)
MYLK4Myosin light chain kinase family member 4. (702 aa)
MYOZ3Myozenin 3. (241 aa)
CORO6Coronin; Belongs to the WD repeat coronin family. (698 aa)
ACTA2Actin, aortic smooth muscle, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells; Belongs to the actin family. (377 aa)
DYSFUncharacterized protein. (2110 aa)
ENSGALP00000068828Uncharacterized protein. (185 aa)
MYOCDPhosphatase and actin regulator. (908 aa)
ENSGALP00000069840Phosphagen kinase C-terminal domain-containing protein; Belongs to the ATP:guanido phosphotransferase family. (843 aa)
SMPXUncharacterized protein. (88 aa)
ENSGALP00000070799SH3 domain-containing protein. (249 aa)
MYF6Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. (341 aa)
MEF2AMyocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development. (545 aa)
FBXO40F-box protein 40. (707 aa)
ACTG2Actin, gamma-enteric smooth muscle. (506 aa)
GAMTRMT2 domain-containing protein. (876 aa)
TNNI1Troponin I1, slow skeletal type. (189 aa)
ENSGALP00000073668Myosin_tail_1 domain-containing protein. (254 aa)
ENSGALP00000073678Uncharacterized protein. (419 aa)
SCO1SCO cytochrome c oxidase assembly protein 1. (558 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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