(21 nodes) Muscle protein, and Striated Muscle Contraction network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	MYH1G	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1941 aa)
	TNNC1	Troponin C, slow skeletal and cardiac muscles; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (215 aa)
	MYL1	Myosin light chain 1, skeletal muscle isoform. (192 aa)
	TNNI2	Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (183 aa)
	TNNC2	Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. (163 aa)
	TPM3	Uncharacterized protein; Belongs to the tropomyosin family. (332 aa)
	MYL2	Myosin regulatory light chain 2A, cardiac muscle isoform. (202 aa)
	MYH15	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1937 aa)
	MYBPC1	Myosin binding protein C, slow type. (1227 aa)
	MYL3	Myosin light chain 1, cardiac muscle. (194 aa)
	MYH1E	Myosin heavy chain, skeletal muscle, adult; Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin. (1939 aa)
	TNNT1	Uncharacterized protein. (272 aa)
	MYH7	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1931 aa)
	TNNT2	Troponin T, cardiac muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (302 aa)
	MYL10	Myosin regulatory light chain 2B, cardiac muscle isoform. (187 aa)
	MYBPC3	Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle A bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. May be involved in the early phase of myofibrillogenesis; Belongs to the immunoglobulin superfamily. MyBP family. (1285 aa)
	TPM1	Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family. (321 aa)
	MYH1B	Myosin-1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1944 aa)
	ACTC1	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. (377 aa)
	TNNT3	Troponin T, fast skeletal muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (220 aa)
	TNNI1	Troponin I1, slow skeletal type. (189 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACTC1	MYBPC3	ENSGALP00000062307	ENSGALP00000053390	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle A bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. May be involved in the early phase of myofibrillogenesis; Belongs to the immunoglobulin superfamily. MyBP family.	0.858
ACTC1	MYH15	ENSGALP00000062307	ENSGALP00000036100	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.795
ACTC1	MYH1B	ENSGALP00000062307	ENSGALP00000061299	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin-1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.561
ACTC1	MYH1E	ENSGALP00000062307	ENSGALP00000045379	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin heavy chain, skeletal muscle, adult; Muscle contraction. Myosin is a protein that binds to F-actin and has ATPase activity that is activated by F-actin.	0.927
ACTC1	MYH7	ENSGALP00000062307	ENSGALP00000048124	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.982
ACTC1	MYL1	ENSGALP00000062307	ENSGALP00000004578	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin light chain 1, skeletal muscle isoform.	0.933
ACTC1	MYL10	ENSGALP00000062307	ENSGALP00000051468	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin regulatory light chain 2B, cardiac muscle isoform.	0.827
ACTC1	MYL2	ENSGALP00000062307	ENSGALP00000034439	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin regulatory light chain 2A, cardiac muscle isoform.	0.982
ACTC1	MYL3	ENSGALP00000062307	ENSGALP00000043277	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Myosin light chain 1, cardiac muscle.	0.973
ACTC1	TNNC2	ENSGALP00000062307	ENSGALP00000011046	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Troponin C, skeletal muscle; Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.	0.657
ACTC1	TNNI1	ENSGALP00000062307	ENSGALP00000073617	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Troponin I1, slow skeletal type.	0.674
ACTC1	TNNI2	ENSGALP00000062307	ENSGALP00000010627	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Troponin I, fast skeletal muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.552
ACTC1	TNNT1	ENSGALP00000062307	ENSGALP00000045602	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Uncharacterized protein.	0.436
ACTC1	TNNT2	ENSGALP00000062307	ENSGALP00000050238	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Troponin T, cardiac muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.987
ACTC1	TNNT3	ENSGALP00000062307	ENSGALP00000063676	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Troponin T, fast skeletal muscle isoforms; Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.	0.597
ACTC1	TPM1	ENSGALP00000062307	ENSGALP00000056013	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Tropomyosin alpha-1 chain; Binds to actin filaments in muscle and non-muscle cells. Plays a central role, in association with the troponin complex, in the calcium dependent regulation of vertebrate striated muscle contraction. Smooth muscle contraction is regulated by interaction with caldesmon. In non-muscle cells is implicated in stabilizing cytoskeleton actin filaments; Belongs to the tropomyosin family.	0.982
ACTC1	TPM3	ENSGALP00000062307	ENSGALP00000022004	Actin, alpha cardiac muscle 1, intermediate form; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.	Uncharacterized protein; Belongs to the tropomyosin family.	0.952
MYBPC1	MYBPC3	ENSGALP00000036825	ENSGALP00000053390	Myosin binding protein C, slow type.	Myosin-binding protein C, cardiac-type; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle A bands. In vitro it binds MHC, F- actin and native thin filaments, and modifies the activity of actin- activated myosin ATPase. It may modulate muscle contraction or may play a more structural role. May be involved in the early phase of myofibrillogenesis; Belongs to the immunoglobulin superfamily. MyBP family.	0.821
MYBPC1	MYH15	ENSGALP00000036825	ENSGALP00000036100	Myosin binding protein C, slow type.	Uncharacterized protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.424
MYBPC1	MYH1B	ENSGALP00000036825	ENSGALP00000061299	Myosin binding protein C, slow type.	Myosin-1B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.	0.720