(14 nodes) Mixed, incl. Myogenic factor, and MADS MEF2-like network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KLHL40	Kelch like family member 40. (587 aa)
	LMOD3	Leiomodin 3. (524 aa)
	TMEM8C	Uncharacterized protein. (220 aa)
	MYOD1	Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity). (299 aa)
	MYOG	Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (227 aa)
	MYH1D	Myosin-1B; Muscle contraction. (1940 aa)
	MYF5	Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity). (258 aa)
	PAX7	PAX7 protein. (524 aa)
	TMEM182	Transmembrane protein 182. (233 aa)
	MEF2D	MADS-box domain-containing protein. (570 aa)
	PAX3	Paired-box transcription factor protein PAX3. (484 aa)
	MEF2B	Myocyte enhancer factor 2B. (398 aa)
	MYF6	Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein. (341 aa)
	MEF2A	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development. (545 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KLHL40	LMOD3	ENSGALP00000008470	ENSGALP00000029247	Kelch like family member 40.	Leiomodin 3.	0.873
KLHL40	MYF6	ENSGALP00000008470	ENSGALP00000070971	Kelch like family member 40.	Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.	0.611
KLHL40	MYH1D	ENSGALP00000008470	ENSGALP00000041897	Kelch like family member 40.	Myosin-1B; Muscle contraction.	0.503
KLHL40	MYOD1	ENSGALP00000008470	ENSGALP00000038684	Kelch like family member 40.	Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.528
KLHL40	MYOG	ENSGALP00000008470	ENSGALP00000039912	Kelch like family member 40.	Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).	0.475
KLHL40	TMEM182	ENSGALP00000008470	ENSGALP00000045272	Kelch like family member 40.	Transmembrane protein 182.	0.748
KLHL40	TMEM8C	ENSGALP00000008470	ENSGALP00000034141	Kelch like family member 40.	Uncharacterized protein.	0.452
LMOD3	KLHL40	ENSGALP00000029247	ENSGALP00000008470	Leiomodin 3.	Kelch like family member 40.	0.873
LMOD3	MYOD1	ENSGALP00000029247	ENSGALP00000038684	Leiomodin 3.	Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.435
LMOD3	MYOG	ENSGALP00000029247	ENSGALP00000039912	Leiomodin 3.	Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).	0.407
LMOD3	TMEM182	ENSGALP00000029247	ENSGALP00000045272	Leiomodin 3.	Transmembrane protein 182.	0.402
LMOD3	TMEM8C	ENSGALP00000029247	ENSGALP00000034141	Leiomodin 3.	Uncharacterized protein.	0.423
MEF2A	MEF2B	ENSGALP00000071199	ENSGALP00000065629	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development.	Myocyte enhancer factor 2B.	0.413
MEF2A	MEF2D	ENSGALP00000071199	ENSGALP00000045472	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development.	MADS-box domain-containing protein.	0.453
MEF2A	MYF5	ENSGALP00000071199	ENSGALP00000043455	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development.	Myogenic factor 5; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).	0.648
MEF2A	MYF6	ENSGALP00000071199	ENSGALP00000070971	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development.	Myogenic factor 6; Involved in muscle differentiation (myogenic factor). Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein.	0.646
MEF2A	MYOD1	ENSGALP00000071199	ENSGALP00000038684	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development.	Myoblast determination protein 1 homolog; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Interacts with and is inhibited by the twist protein. This interaction probably involves the basic domains of both proteins (By similarity).	0.730
MEF2A	MYOG	ENSGALP00000071199	ENSGALP00000039912	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development.	Myogenin; Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein (By similarity).	0.752
MEF2A	PAX7	ENSGALP00000071199	ENSGALP00000044020	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development.	PAX7 protein.	0.482
MEF2B	MEF2A	ENSGALP00000065629	ENSGALP00000071199	Myocyte enhancer factor 2B.	Myocyte-specific enhancer factor 2A; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Mediates cellular functions in skeletal and cardiac muscle development.	0.413