STRINGSTRING
ESPN ESPN PCDH15 PCDH15 OCM OCM SLC9A3R2 SLC9A3R2 USH1C USH1C SLC26A5 SLC26A5 MYO3B MYO3B USH2A USH2A CLRN1 CLRN1 PTPRQ PTPRQ RDX RDX EZR EZR TMC1 TMC1 TMPRSS3 TMPRSS3 OTOF OTOF GJB2 GJB2 GRXCR1 GRXCR1 FSCN2 FSCN2 PDZD7-2 PDZD7-2 ENSGALP00000044845 ENSGALP00000044845 LHFPL5 LHFPL5 USH1G USH1G MSN MSN TMC2 TMC2 CIB2 CIB2 POU4F3 POU4F3 KCNQ4 KCNQ4 IKZF2 IKZF2 MYO3A MYO3A GFI1 GFI1 SLC17A8 SLC17A8 PLS1 PLS1 CLIC5 CLIC5 CDH23 CDH23 EPS8L2 EPS8L2 GIPC3 GIPC3 TPRN TPRN EPS8 EPS8 CTBP2 CTBP2 SLC26A4 SLC26A4 GJB6 GJB6 SLC9A3R1 SLC9A3R1 ESPNL ESPNL ENSGALP00000067109 ENSGALP00000067109 PITPNM1 PITPNM1 USH1C-2 USH1C-2 WHRN WHRN PODXL PODXL PDZD7 PDZD7 MYO7A MYO7A MYO15A MYO15A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ESPNWH2 domain-containing protein. (371 aa)
PCDH15Protocadherin-15; Calcium-dependent cell-adhesion protein. Required for inner ear neuroepithelial cell elaboration and cochlear function. Probably involved in the maintenance of normal retinal function (By similarity). (2192 aa)
OCMParvalbumin, thymic CPV3; Binds two calcium ions. (109 aa)
SLC9A3R2Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (354 aa)
USH1CUSH1 protein network component harmonin. (556 aa)
SLC26A5Prestin. (742 aa)
MYO3BMyosin IIIB; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1287 aa)
USH2AUsherin. (5190 aa)
CLRN1Clarin 1. (232 aa)
PTPRQProtein tyrosine phosphatase receptor type Q. (2308 aa)
RDXRadixin; Probably plays a crucial role in the binding of the barbed end of actin filaments to the plasma membrane. (583 aa)
EZREzrin. (585 aa)
TMC1Transmembrane channel-like protein. (847 aa)
TMPRSS3Transmembrane serine protease 3; Belongs to the peptidase S1 family. (470 aa)
OTOFOtoferlin. (1810 aa)
GJB2Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (225 aa)
GRXCR1Glutaredoxin and cysteine rich domain containing 1. (293 aa)
FSCN2Fascin. (491 aa)
PDZD7-2Uncharacterized protein. (548 aa)
ENSGALP00000044845PTB domain-containing protein. (147 aa)
LHFPL5LHFPL tetraspan subfamily member 5 protein. (221 aa)
USH1GUSH1 protein network component sans. (457 aa)
MSNMoesin. (580 aa)
TMC2Transmembrane channel-like protein. (863 aa)
CIB2Uncharacterized protein. (203 aa)
POU4F3POU domain protein. (326 aa)
KCNQ4Potassium voltage-gated channel subfamily Q member 4; Belongs to the potassium channel family. (667 aa)
IKZF2Uncharacterized protein. (562 aa)
MYO3AMyosin IIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1632 aa)
GFI1Growth factor independent 1 transcriptional repressor. (405 aa)
SLC17A8MFS domain-containing protein. (587 aa)
PLS1Plastin-1; Actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. (630 aa)
CLIC5Chloride intracellular channel protein; Belongs to the chloride channel CLIC family. (389 aa)
CDH23Cadherin related 23. (1378 aa)
EPS8L2Uncharacterized protein. (199 aa)
GIPC3GIPC PDZ domain containing family member 3. (539 aa)
TPRNPhostensin domain-containing protein. (125 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (828 aa)
CTBP2C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (442 aa)
SLC26A4Pendrin; Sodium-independent transporter of chloride and iodide. Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. (816 aa)
GJB6Gap junction beta-6 protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. (263 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF1; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. Was first known to play a role in the regulation of the activity and subcellular location of SLC9A3. May enhance Wnt signaling (By similarity). (366 aa)
ESPNLEspin like. (596 aa)
ENSGALP00000067109Uncharacterized protein. (966 aa)
PITPNM1Uncharacterized protein. (470 aa)
USH1C-2Uncharacterized protein. (128 aa)
WHRNWhirlin. (926 aa)
PODXLPodocalyxin; Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro- adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubul [...] (589 aa)
PDZD7PDZ domain-containing protein. (413 aa)
MYO7AMyosin VIIA; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2183 aa)
MYO15AUncharacterized protein. (807 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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