(39 nodes) Glycolytic process, and Sugar-phosphatase activity network (Gallus gallus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	PFKFB2	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2. (686 aa)
	ADPGK	Uncharacterized protein. (489 aa)
	H6PD	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase. (790 aa)
	HKDC1	Hexokinase domain containing 1. (917 aa)
	HK1	Uncharacterized protein. (780 aa)
	TKT	Transketolase. (627 aa)
	PGK2	Phosphoglycerate kinase; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility. (417 aa)
	G6PC2	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (355 aa)
	LCT	Uncharacterized protein. (1935 aa)
	FBP1	FBPase domain-containing protein; Belongs to the FBPase class 1 family. (484 aa)
	BPGM	Phosphoglycerate mutase; Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. (259 aa)
	AKR1B10	Aldo-keto reductase. (317 aa)
	DERA	Uncharacterized protein. (318 aa)
	TPI1	Triosephosphate isomerase; Triosephosphate isomerase is an extremely efficient metabolic enzyme that catalyzes the interconversion between dihydroxyacetone phosphate (DHAP) and D-glyceraldehyde-3-phosphate (G3P) in glycolysis and gluconeogenesis. (248 aa)
	ALDOB	Fructose-bisphosphate aldolase B. (364 aa)
	PGAM1	Phosphoglycerate mutase 1; Interconversion of 3- and 2-phosphoglycerate with 2,3- bisphosphoglycerate as the primer of the reaction. Can also catalyze the reaction of EC 5.4.2.4 (synthase), but with a reduced activity. (254 aa)
	PFKL	ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily. (780 aa)
	TIGAR	TIGAR. (280 aa)
	ALDOC	Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family. (364 aa)
	PFKP	6-phosphofructokinase; Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. (831 aa)
	PKLR	Pyruvate kinase PKM; Plays a key role in glycolysis; Belongs to the pyruvate kinase family. (550 aa)
	TALDO1	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. (337 aa)
	PFKFB3	6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3. (539 aa)
	GCK	Phosphotransferase. (465 aa)
	FBP2	Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family. (340 aa)
	PFKM	Uncharacterized protein. (736 aa)
	G6PC	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (352 aa)
	GLB1	Beta-galactosidase. (652 aa)
	ENO1	Alpha-enolase. (447 aa)
	GPI	Glucose-6-phosphate isomerase; Belongs to the GPI family. (553 aa)
	ENO2	Gamma-enolase; Belongs to the enolase family. (434 aa)
	GAPDH	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...] (333 aa)
	MYCBPAP	MYCBP associated protein. (946 aa)
	LOC107051217	Gp_dh_C domain-containing protein. (307 aa)
	G6PC3	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family. (342 aa)
	HK2	Uncharacterized protein. (1245 aa)
	ENO4	Enolase 4. (623 aa)
	PFKFB4L	6PF2K domain-containing protein. (626 aa)
	PFKFB4	6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase; Synthesis and degradation of fructose 2,6-bisphosphate; In the C-terminal section; belongs to the phosphoglycerate mutase family. (658 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADPGK	ALDOB	ENSGALP00000002754	ENSGALP00000036836	Uncharacterized protein.	Fructose-bisphosphate aldolase B.	0.929
ADPGK	ALDOC	ENSGALP00000002754	ENSGALP00000043256	Uncharacterized protein.	Fructose-bisphosphate aldolase C; Belongs to the class I fructose-bisphosphate aldolase family.	0.930
ADPGK	DERA	ENSGALP00000002754	ENSGALP00000021349	Uncharacterized protein.	Uncharacterized protein.	0.804
ADPGK	ENO2	ENSGALP00000002754	ENSGALP00000061472	Uncharacterized protein.	Gamma-enolase; Belongs to the enolase family.	0.496
ADPGK	FBP1	ENSGALP00000002754	ENSGALP00000020563	Uncharacterized protein.	FBPase domain-containing protein; Belongs to the FBPase class 1 family.	0.520
ADPGK	FBP2	ENSGALP00000002754	ENSGALP00000054285	Uncharacterized protein.	Fructose-bisphosphatase 2; Belongs to the FBPase class 1 family.	0.658
ADPGK	G6PC	ENSGALP00000002754	ENSGALP00000057482	Uncharacterized protein.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.900
ADPGK	G6PC2	ENSGALP00000002754	ENSGALP00000017702	Uncharacterized protein.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.900
ADPGK	G6PC3	ENSGALP00000002754	ENSGALP00000067948	Uncharacterized protein.	Glucose-6-phosphatase; Belongs to the glucose-6-phosphatase family.	0.900
ADPGK	GAPDH	ENSGALP00000002754	ENSGALP00000063325	Uncharacterized protein.	Glyceraldehyde-3-phosphate dehydrogenase; Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are proba [...]	0.499
ADPGK	GCK	ENSGALP00000002754	ENSGALP00000053403	Uncharacterized protein.	Phosphotransferase.	0.950
ADPGK	GPI	ENSGALP00000002754	ENSGALP00000060970	Uncharacterized protein.	Glucose-6-phosphate isomerase; Belongs to the GPI family.	0.996
ADPGK	H6PD	ENSGALP00000002754	ENSGALP00000003917	Uncharacterized protein.	Hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase.	0.809
ADPGK	HK1	ENSGALP00000002754	ENSGALP00000006708	Uncharacterized protein.	Uncharacterized protein.	0.927
ADPGK	HK2	ENSGALP00000002754	ENSGALP00000068030	Uncharacterized protein.	Uncharacterized protein.	0.938
ADPGK	HKDC1	ENSGALP00000002754	ENSGALP00000006706	Uncharacterized protein.	Hexokinase domain containing 1.	0.927
ADPGK	LOC107051217	ENSGALP00000002754	ENSGALP00000066789	Uncharacterized protein.	Gp_dh_C domain-containing protein.	0.491
ADPGK	MYCBPAP	ENSGALP00000002754	ENSGALP00000065475	Uncharacterized protein.	MYCBP associated protein.	0.412
ADPGK	PGK2	ENSGALP00000002754	ENSGALP00000012878	Uncharacterized protein.	Phosphoglycerate kinase; Catalyzes one of the two ATP producing reactions in the glycolytic pathway via the reversible conversion of 1,3- diphosphoglycerate to 3-phosphoglycerate. In addition to its role as a glycolytic enzyme, it seems that PGK-1 acts as a polymerase alpha cofactor protein (primer recognition protein). May play a role in sperm motility.	0.480
ADPGK	TALDO1	ENSGALP00000002754	ENSGALP00000050308	Uncharacterized protein.	Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway.	0.800