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CYP1A2 CYP1A2 HSD11B1b HSD11B1b R3HDM4 R3HDM4 DHCR7 DHCR7 UGT1A1 UGT1A1 CYP3A4 CYP3A4 CYP3A5 CYP3A5 DHRS11 DHRS11 SDR42E1 SDR42E1 HSD17B2 HSD17B2 CYP2C23b CYP2C23b CH25H CH25H IDI2 IDI2 MVD MVD MSMO1 MSMO1 NPC2 NPC2 CYP4B7 CYP4B7 CYP4A22 CYP4A22 SRD5A2 SRD5A2 DHCR24 DHCR24 CYP46A1 CYP46A1 UGT2A1 UGT2A1 CYP2D6 CYP2D6 AKR1D1 AKR1D1 SRD5A1 SRD5A1 MVK MVK HMGCR HMGCR NPC1 NPC1 PTGR1 PTGR1 CYP26B1 CYP26B1 FDFT1 FDFT1 INSIG1 INSIG1 NSDHL NSDHL CYP17A1 CYP17A1 CYP1A1 CYP1A1 FDX1 FDX1 HSD11B2 HSD11B2 INSIG2 INSIG2 SREBF1 SREBF1 FDPS FDPS CYP21A1 CYP21A1 SQLE SQLE CYP7B1 CYP7B1 ENSGALP00000046146 ENSGALP00000046146 HMGCS1 HMGCS1 LSS LSS CYP11A1 CYP11A1 RP11-400G3.5 RP11-400G3.5 CYP7A1 CYP7A1 LOC101749846 LOC101749846 SIGMAR1 SIGMAR1 HSD17B7 HSD17B7 SREBF2 SREBF2 PMVK PMVK HSD17B3 HSD17B3 C5H14orf1 C5H14orf1 CYP51A1 CYP51A1 RGS22 RGS22 CYP39A1 CYP39A1 CYP19A1 CYP19A1 FDXR FDXR STS STS LOC769841 LOC769841 SC5D SC5D HSD3B1 HSD3B1 SCAP SCAP HMGCS2 HMGCS2 POR POR FAXDC2 FAXDC2
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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CYP1A2Cytochrome P450 1A5; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
HSD11B1bUncharacterized protein. (301 aa)
R3HDM4R3H domain containing 4. (263 aa)
DHCR7Uncharacterized protein. (474 aa)
UGT1A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (532 aa)
CYP3A4Uncharacterized protein; Belongs to the cytochrome P450 family. (540 aa)
CYP3A5Uncharacterized protein. (508 aa)
DHRS11Dehydrogenase/reductase SDR family member 11; Catalyzes the conversion of the 17-keto group of estrone, 4- and 5-androstenes and 5-alpha-androstanes into their 17-beta- hydroxyl metabolites and the conversion of the 3-keto group of 3-, 3,17- and 3,20- diketosteroids into their 3-hydroxyl metabolites. Exhibits reductive 3-beta-hydroxysteroid dehydrogenase activity toward 5-beta-androstanes, 5-beta-pregnanes, 4-pregnenes and bile acids. May also reduce endogenous and exogenous alpha-dicarbonyl compounds and xenobiotic alicyclic ketones. (255 aa)
SDR42E1Short chain dehydrogenase/reductase family 42E, member 1; Belongs to the 3-beta-HSD family. (391 aa)
HSD17B2Hydroxysteroid 17-beta dehydrogenase 2; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (384 aa)
CYP2C23bCytochrome P450 2H2; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (491 aa)
CH25HFatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (274 aa)
IDI2Nudix hydrolase domain-containing protein. (282 aa)
MVDMevalonate diphosphate decarboxylase. (629 aa)
MSMO1Methylsterol monooxygenase 1; Catalyzes the first step in the removal of the two C-4 methyl groups of 4,4-dimethylzymosterol; Belongs to the sterol desaturase family. (296 aa)
NPC2ML domain-containing protein. (148 aa)
CYP4B7Uncharacterized protein; Belongs to the cytochrome P450 family. (504 aa)
CYP4A22Uncharacterized protein. (507 aa)
SRD5A23-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (255 aa)
DHCR24FAD-binding PCMH-type domain-containing protein. (516 aa)
CYP46A1Uncharacterized protein; Belongs to the cytochrome P450 family. (499 aa)
UGT2A1UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. (529 aa)
CYP2D6Cytochrome P450 CYP2D49; Belongs to the cytochrome P450 family. (502 aa)
AKR1D1Aldo_ket_red domain-containing protein. (448 aa)
SRD5A13-oxo-5-alpha-steroid 4-dehydrogenase; Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3- oxosteroids. It plays a central role in sexual differentiation and androgen physiology. (266 aa)
MVKMevalonate kinase; Catalyzes the phosphorylation of mevalonate to mevalonate 5- phosphate, a key step in isoprenoid and cholesterol biosynthesis. Belongs to the GHMP kinase family. Mevalonate kinase subfamily. (397 aa)
HMGCR3-hydroxy-3-methylglutaryl coenzyme A reductase. (930 aa)
NPC1NPC intracellular cholesterol transporter 1. (1286 aa)
PTGR1PKS_ER domain-containing protein. (329 aa)
CYP26B1Cytochrome P450 family 26 subfamily B member 1; Belongs to the cytochrome P450 family. (511 aa)
FDFT1Uncharacterized protein. (418 aa)
INSIG1Insulin-induced gene 1 protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (252 aa)
NSDHLNAD(P) dependent steroid dehydrogenase-like; Belongs to the 3-beta-HSD family. (346 aa)
CYP17A1Steroid 17-alpha-hydroxylase/17,20 lyase; Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. (527 aa)
CYP1A1Cytochrome P450 1A4; Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. (530 aa)
FDX1Adrenodoxin, mitochondrial; Essential for the synthesis of various steroid hormones. Participates in the reduction of mitochondrial cytochrome P450 for steroidogenesis. Transfers electrons from adrenodoxin reductase to CYP11A1, a cytochrome P450 that catalyzes cholesterol side-chain cleavage. Does not form a ternary complex with adrenodoxin reductase and CYP11A1 but shuttles between the two enzymes to transfer electrons. (178 aa)
HSD11B2Hydroxysteroid 11-beta dehydrogenase 2. (349 aa)
INSIG2Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (225 aa)
SREBF1BHLH domain-containing protein. (1116 aa)
FDPSFarnesyl pyrophosphate synthase; Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate; Belongs to the FPP/GGPP synthase family. (354 aa)
CYP21A1Steroid 21-hydroxylase; Belongs to the cytochrome P450 family. (478 aa)
SQLESE domain-containing protein. (573 aa)
CYP7B1Cytochrome P450 family 7 subfamily B member 1; Belongs to the cytochrome P450 family. (487 aa)
ENSGALP00000046146Uncharacterized protein. (576 aa)
HMGCS1Hydroxymethylglutaryl-CoA synthase, cytoplasmic; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. (542 aa)
LSSTerpene cyclase/mutase family member; Belongs to the terpene cyclase/mutase family. (757 aa)
CYP11A1Cholesterol side-chain cleavage enzyme, mitochondrial; A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R- hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the se [...] (508 aa)
RP11-400G3.5Uncharacterized protein; Belongs to the cytochrome P450 family. (494 aa)
CYP7A1Cholesterol 7-alpha-monooxygenase; Belongs to the cytochrome P450 family. (513 aa)
LOC101749846Uncharacterized protein; Belongs to the cytochrome P450 family. (668 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1; May function in lipid transport from the endoplasmic reticulum and be involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. May regulate calcium efflux at the endoplasmic reticulum (By similarity). (242 aa)
HSD17B7Uncharacterized protein. (332 aa)
SREBF2Sterol regulatory element binding transcription factor 2. (1112 aa)
PMVKPhosphomevalonate kinase. (188 aa)
HSD17B3Hydroxysteroid 17-beta dehydrogenase 3; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (276 aa)
C5H14orf1Uncharacterized protein. (336 aa)
CYP51A1Uncharacterized protein; Belongs to the cytochrome P450 family. (496 aa)
RGS22Uncharacterized protein. (571 aa)
CYP39A1Cytochrome P450 family 39 subfamily A member 1; Belongs to the cytochrome P450 family. (466 aa)
CYP19A1Aromatase; Catalyzes the formation of aromatic C18 estrogens from C19 androgens. (502 aa)
FDXRNADPH:adrenodoxin oxidoreductase, mitochondrial. (519 aa)
STSSteroid sulfatase. (600 aa)
LOC769841Sulfotransferase; Belongs to the sulfotransferase 1 family. (295 aa)
SC5DSterol-C5-desaturase; Belongs to the sterol desaturase family. (442 aa)
HSD3B13Beta_HSD domain-containing protein. (484 aa)
SCAPSREBF chaperone. (1316 aa)
HMGCS23-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. (517 aa)
PORNADPH--cytochrome P450 reductase; This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5; In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. (676 aa)
FAXDC2Fatty acid hydroxylase domain-containing protein; Belongs to the sterol desaturase family. (335 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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