(16 nodes) Detoxification of Reactive Oxygen Species, and Peptide methionine sulfoxide reductase network (Gallus gallus)

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	SOD2	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (224 aa)
	SOD3	Superoxide dismutase 3. (307 aa)
	GLRX	Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family. (101 aa)
	TXN	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...] (105 aa)
	SOD1	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (164 aa)
	GPX8	Glutathione peroxidase; Belongs to the glutathione peroxidase family. (210 aa)
	ENSGALP00000046435	Thioredoxin domain-containing protein. (132 aa)
	PRDX1	Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...] (199 aa)
	PRDX3	Peroxiredoxin 3. (309 aa)
	TXN2	Thioredoxin domain-containing protein. (150 aa)
	CAT	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. (528 aa)
	MSRB3	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues. (208 aa)
	TXNIP	Thioredoxin interacting protein. (430 aa)
	SRXN1	Sulfiredoxin. (155 aa)
	MSRA	Methionine sulfoxide reductase A. (253 aa)
	LOC101749201	PMSR domain-containing protein. (223 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CAT	GLRX	ENSGALP00000063417	ENSGALP00000023602	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family.	0.469
CAT	GPX8	ENSGALP00000063417	ENSGALP00000041079	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.556
CAT	LOC101749201	ENSGALP00000063417	ENSGALP00000073960	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	PMSR domain-containing protein.	0.559
CAT	MSRA	ENSGALP00000063417	ENSGALP00000073044	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Methionine sulfoxide reductase A.	0.559
CAT	MSRB3	ENSGALP00000063417	ENSGALP00000065695	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Peptide-methionine (R)-S-oxide reductase; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residues.	0.657
CAT	PRDX1	ENSGALP00000063417	ENSGALP00000048502	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...]	0.689
CAT	PRDX3	ENSGALP00000063417	ENSGALP00000054508	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Peroxiredoxin 3.	0.691
CAT	SOD1	ENSGALP00000063417	ENSGALP00000035996	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family.	0.935
CAT	SOD2	ENSGALP00000063417	ENSGALP00000019039	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Superoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.	0.964
CAT	SOD3	ENSGALP00000063417	ENSGALP00000023211	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Superoxide dismutase 3.	0.935
CAT	SRXN1	ENSGALP00000063417	ENSGALP00000072702	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Sulfiredoxin.	0.531
CAT	TXN	ENSGALP00000063417	ENSGALP00000025280	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	Thioredoxin; Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (By similarity). Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA binding activity in ionizing radiation (IR) cells through its oxidation/reduction status [...]	0.638
ENSGALP00000046435	LOC101749201	ENSGALP00000046435	ENSGALP00000073960	Thioredoxin domain-containing protein.	PMSR domain-containing protein.	0.536
ENSGALP00000046435	MSRA	ENSGALP00000046435	ENSGALP00000073044	Thioredoxin domain-containing protein.	Methionine sulfoxide reductase A.	0.536
ENSGALP00000046435	PRDX1	ENSGALP00000046435	ENSGALP00000048502	Thioredoxin domain-containing protein.	Peroxiredoxin-1; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2) (By similarity). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron diffe [...]	0.535
ENSGALP00000046435	PRDX3	ENSGALP00000046435	ENSGALP00000054508	Thioredoxin domain-containing protein.	Peroxiredoxin 3.	0.535
ENSGALP00000046435	TXN2	ENSGALP00000046435	ENSGALP00000057422	Thioredoxin domain-containing protein.	Thioredoxin domain-containing protein.	0.531
GLRX	CAT	ENSGALP00000023602	ENSGALP00000063417	Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family.	Catalase; Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.	0.469
GLRX	GPX8	ENSGALP00000023602	ENSGALP00000041079	Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family.	Glutathione peroxidase; Belongs to the glutathione peroxidase family.	0.622
GLRX	LOC101749201	ENSGALP00000023602	ENSGALP00000073960	Glutaredoxin-1; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins; Belongs to the glutaredoxin family.	PMSR domain-containing protein.	0.675