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ENTPD4 ENTPD4 AMPD1 AMPD1 NME4 NME4 ITPA ITPA UCK2 UCK2 UCK1 UCK1 ADA ADA NT5M NT5M ADK ADK LOC769866 LOC769866 AMPD3 AMPD3 DGUOK DGUOK HPRT1 HPRT1 CDA CDA UPRT UPRT NT5C2 NT5C2 ENTPD8 ENTPD8 LOC427778 LOC427778 ENTPD8L ENTPD8L ENTPD5 ENTPD5 GMPS GMPS CMPK1 CMPK1 DCTD DCTD ADSS ADSS AK4 AK4 AK7 AK7 PDE4B PDE4B ADSS1 ADSS1 CANT1 CANT1 ADSL ADSL AK9 AK9 NT5E NT5E RRM2 RRM2 NT5C1B NT5C1B CTPS2 CTPS2 RRM1 RRM1 TPMT TPMT AK6 AK6 NME2 NME2 PDE3A PDE3A PDE3B PDE3B DCK DCK GMPR2 GMPR2 APRT APRT AMPD2 AMPD2 LOC776992 LOC776992 RRM2B RRM2B NME6 NME6 TK1 TK1 DTYMK DTYMK NT5C3A NT5C3A AK3 AK3 IMPDH2 IMPDH2 ENPP1 ENPP1 AK8 AK8 ENTPD3 ENTPD3 ENPP3 ENPP3 ENTPD1 ENTPD1 GUK1 GUK1 PNP PNP ENTPD6 ENTPD6 HDDC3 HDDC3 ENTPD2 ENTPD2 UPP2 UPP2 CTPS1 CTPS1 DUT DUT NME3 NME3 PDE7B PDE7B NUDT2 NUDT2 AK5 AK5 AK1 AK1 ENSGALP00000067330 ENSGALP00000067330 TK2 TK2 NT5C1A NT5C1A NME7 NME7 UPP1 UPP1 PDE10A PDE10A LOC770392 LOC770392 ADCY10L11 ADCY10L11 PDE1C PDE1C PDE1B PDE1B PDE1A PDE1A NTPCR NTPCR CECR1 CECR1 NT5C3B NT5C3B
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
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ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa)
AMPD1AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (707 aa)
NME4Nucleoside diphosphate kinase. (186 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (201 aa)
UCK2Uridine-cytidine kinase; Belongs to the uridine kinase family. (261 aa)
UCK1Uridine-cytidine kinase; Belongs to the uridine kinase family. (272 aa)
ADAAdenosine deaminase; Catalyzes the hydrolytic deamination of adenosine and 2- deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. May act as a positive regulator of T-cell coactivation (By similarity). Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (357 aa)
NT5M5',3'-nucleotidase, mitochondrial. (230 aa)
ADKPfkB domain-containing protein. (359 aa)
LOC769866Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (208 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (765 aa)
DGUOKDeoxyadenosine kinase. (265 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (330 aa)
CDACytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis; Belongs to the cytidine and deoxycytidylate deaminase family. (191 aa)
UPRTUracil phosphoribosyltransferase homolog. (277 aa)
NT5C2Cytosolic purine 5'-nucleotidase; May have a critical role in the maintenance of a constant composition of intracellular purine/pyrimidine nucleotides in cooperation with other nucleotidases. Preferentially hydrolyzes inosine 5'-monophosphate (IMP) and other purine nucleotides (By similarity). (598 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside ATPases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Belongs to the GDA1/CD39 NTPase family. (493 aa)
LOC427778Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (497 aa)
ENTPD8LUncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (416 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thia [...] (443 aa)
GMPSUncharacterized protein. (759 aa)
CMPK1UMP-CMP kinase; Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity; Belongs to the adenylate kinase family. UMP-CMP kinase subfamily. (196 aa)
DCTDCMP/dCMP-type deaminase domain-containing protein. (190 aa)
ADSSAdenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (516 aa)
AK4Adenylate kinase 4; Belongs to the adenylate kinase family. (171 aa)
AK7Adenylate kinase 7. (715 aa)
PDE4BPhosphodiesterase. (563 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
CANT1Uncharacterized protein. (408 aa)
ADSLAdenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (485 aa)
AK9Uncharacterized protein. (1077 aa)
NT5E5'-nucleotidase ecto; Belongs to the 5'-nucleotidase family. (561 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (384 aa)
NT5C1BUncharacterized protein. (357 aa)
CTPS2CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). (586 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
TPMTThiopurine S-methyltransferase. (239 aa)
AK6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (171 aa)
NME2Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). (153 aa)
PDE3APhosphodiesterase. (850 aa)
PDE3BPhosphodiesterase. (1105 aa)
DCKdNK domain-containing protein. (216 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
APRTPribosyltran domain-containing protein. (179 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (941 aa)
LOC776992Uridine-cytidine kinase; Belongs to the uridine kinase family. (532 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (353 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
TK1Thymidine kinase, cytosolic; Belongs to the thymidine kinase family. (224 aa)
DTYMKThymidylate_kin domain-containing protein. (212 aa)
NT5C3ACytosolic 5'-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. (331 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (234 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (538 aa)
ENPP1Uncharacterized protein. (354 aa)
AK8Uncharacterized protein; Belongs to the adenylate kinase family. (453 aa)
ENTPD3Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (511 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (886 aa)
ENTPD1Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (525 aa)
GUK1Guanylate kinase 1. (237 aa)
PNPPurine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (294 aa)
ENTPD6Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (430 aa)
HDDC3HD domain containing 3. (185 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent (By similarity). (536 aa)
UPP2Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (315 aa)
CTPS1CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (668 aa)
DUTdUTPase domain-containing protein. (187 aa)
NME3Nucleoside diphosphate kinase. (206 aa)
PDE7BPhosphodiesterase. (499 aa)
NUDT2Nudix hydrolase 2. (148 aa)
AK5Adenylate kinase 5; Belongs to the adenylate kinase family. (594 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (194 aa)
ENSGALP00000067330Uncharacterized protein. (320 aa)
TK2dNK domain-containing protein. (236 aa)
NT5C1A5'-nucleotidase, cytosolic IA. (429 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (377 aa)
UPP1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. (313 aa)
PDE10APhosphodiesterase. (1063 aa)
LOC770392Uncharacterized protein. (315 aa)
ADCY10L11Uncharacterized protein. (298 aa)
PDE1CPhosphodiesterase. (767 aa)
PDE1BPhosphodiesterase 1B; Belongs to the cyclic nucleotide phosphodiesterase family. (624 aa)
PDE1APhosphodiesterase. (623 aa)
NTPCRNucleoside-triphosphatase. (190 aa)
CECR1A_deaminase domain-containing protein. (521 aa)
NT5C3B7-methylguanosine phosphate-specific 5'-nucleotidase; Specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has weak activity for CMP. UMP and purine nucleotides are poor substrates (By similarity); Belongs to the pyrimidine 5'-nucleotidase family. (518 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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