STRINGSTRING
ENTPD4 ENTPD4 AMPD1 AMPD1 NME4 NME4 ITPA ITPA LOC769866 LOC769866 AMPD3 AMPD3 HPRT1 HPRT1 ENTPD8 ENTPD8 LOC427778 LOC427778 ENTPD8L ENTPD8L ENTPD5 ENTPD5 GMPS GMPS ADSS ADSS AK4 AK4 AK7 AK7 PDE4B PDE4B ADSS1 ADSS1 CANT1 CANT1 ADSL ADSL AK9 AK9 RRM2 RRM2 NT5C1B NT5C1B CTPS2 CTPS2 RRM1 RRM1 TPMT TPMT AK6 AK6 NME2 NME2 PDE3A PDE3A PDE3B PDE3B GMPR2 GMPR2 APRT APRT AMPD2 AMPD2 RRM2B RRM2B NME6 NME6 NT5C3A NT5C3A AK3 AK3 IMPDH2 IMPDH2 ENPP1 ENPP1 AK8 AK8 ENTPD3 ENTPD3 ENPP3 ENPP3 ENTPD1 ENTPD1 GUK1 GUK1 ENTPD6 ENTPD6 HDDC3 HDDC3 ENTPD2 ENTPD2 CTPS1 CTPS1 NME3 NME3 PDE7B PDE7B NUDT2 NUDT2 AK5 AK5 AK1 AK1 ENSGALP00000067330 ENSGALP00000067330 NT5C1A NT5C1A NME7 NME7 PDE10A PDE10A ADCY10L11 ADCY10L11 PDE1C PDE1C PDE1B PDE1B PDE1A PDE1A NTPCR NTPCR
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENTPD4Ectonucleoside triphosphate diphosphohydrolase 4; Belongs to the GDA1/CD39 NTPase family. (616 aa)
AMPD1AMP deaminase 1; AMP deaminase plays a critical role in energy metabolism; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (707 aa)
NME4Nucleoside diphosphate kinase. (186 aa)
ITPAInosine triphosphate pyrophosphatase; Pyrophosphatase that hydrolyzes the non-canonical purine nucleotides inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triposphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions; Belongs to the HAM1 NTPase family. (201 aa)
LOC769866Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (208 aa)
AMPD3AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (765 aa)
HPRT1Hypoxanthine-guanine phosphoribosyltransferase; Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5- phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway (By similarity). (330 aa)
ENTPD8Ectonucleoside triphosphate diphosphohydrolase 8; Canalicular ectonucleoside NTPDase responsible for the main hepatic NTPDase activity. Ectonucleoside ATPases catalyze the hydrolysis of gamma- and beta-phosphate residues of nucleotides, playing a central role in concentration of extracellular nucleotides. Belongs to the GDA1/CD39 NTPase family. (493 aa)
LOC427778Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (497 aa)
ENTPD8LUncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (416 aa)
ENTPD5Ectonucleoside triphosphate diphosphohydrolase 5; Uridine diphosphatase (UDPase) that promotes protein N- glycosylation and ATP level regulation. UDP hydrolysis promotes protein N-glycosylation and folding in the endoplasmic reticulum, as well as elevated ATP consumption in the cytosol via an ATP hydrolysis cycle. Together with CMPK1 and AK1, constitutes an ATP hydrolysis cycle that converts ATP to AMP and results in a compensatory increase in aerobic glycolysis. The nucleotide hydrolyzing preference is GDP > IDP > UDP, but not any other nucleoside di-, mono- or triphosphates, nor thia [...] (443 aa)
GMPSUncharacterized protein. (759 aa)
ADSSAdenylosuccinate synthetase isozyme 2; Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. (516 aa)
AK4Adenylate kinase 4; Belongs to the adenylate kinase family. (171 aa)
AK7Adenylate kinase 7. (715 aa)
PDE4BPhosphodiesterase. (563 aa)
ADSS1Adenylosuccinate synthetase isozyme 1; Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP. (456 aa)
CANT1Uncharacterized protein. (408 aa)
ADSLAdenylosuccinate lyase; Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D- ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (485 aa)
AK9Uncharacterized protein. (1077 aa)
RRM2Ribonucleotide reductase regulatory subunit M2. (384 aa)
NT5C1BUncharacterized protein. (357 aa)
CTPS2CTP synthase 2; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Constitutes the rate-limiting enzyme in the synthesis of cytosine nucleotides (By similarity). (586 aa)
RRM1Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (790 aa)
TPMTThiopurine S-methyltransferase. (239 aa)
AK6Adenylate kinase isoenzyme 6; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation; Belongs to the adenylate kinase family. AK6 subfamily. (171 aa)
NME2Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). (153 aa)
PDE3APhosphodiesterase. (850 aa)
PDE3BPhosphodiesterase. (1105 aa)
GMPR2GMP reductase; Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. (345 aa)
APRTPribosyltran domain-containing protein. (179 aa)
AMPD2AMP deaminase; Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. (941 aa)
RRM2BRibonucleotide reductase regulatory TP53 inducible subunit M2B. (353 aa)
NME6Nucleoside diphosphate kinase. (186 aa)
NT5C3ACytosolic 5'-nucleotidase 3A; Nucleotidase which shows specific activity towards cytidine monophosphate (CMP) and 7-methylguanosine monophosphate (m(7)GMP). CMP seems to be the preferred substrate. (331 aa)
AK3GTP:AMP phosphotransferase AK3, mitochondrial; Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities. (234 aa)
IMPDH2Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. (538 aa)
ENPP1Uncharacterized protein. (354 aa)
AK8Uncharacterized protein; Belongs to the adenylate kinase family. (453 aa)
ENTPD3Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (511 aa)
ENPP3Ectonucleotide pyrophosphatase/phosphodiesterase 3. (886 aa)
ENTPD1Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (525 aa)
GUK1Guanylate kinase 1. (237 aa)
ENTPD6Uncharacterized protein; Belongs to the GDA1/CD39 NTPase family. (430 aa)
HDDC3HD domain containing 3. (185 aa)
ENTPD2Ectonucleoside triphosphate diphosphohydrolase 2; In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Hydrolyzes ADP only to a marginal extent (By similarity). (536 aa)
CTPS1CTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. (668 aa)
NME3Nucleoside diphosphate kinase. (206 aa)
PDE7BPhosphodiesterase. (499 aa)
NUDT2Nudix hydrolase 2. (148 aa)
AK5Adenylate kinase 5; Belongs to the adenylate kinase family. (594 aa)
AK1Adenylate kinase isoenzyme 1; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. (194 aa)
ENSGALP00000067330Uncharacterized protein. (320 aa)
NT5C1A5'-nucleotidase, cytosolic IA. (429 aa)
NME7Nucleoside diphosphate kinase 7; Belongs to the NDK family. (377 aa)
PDE10APhosphodiesterase. (1063 aa)
ADCY10L11Uncharacterized protein. (298 aa)
PDE1CPhosphodiesterase. (767 aa)
PDE1BPhosphodiesterase 1B; Belongs to the cyclic nucleotide phosphodiesterase family. (624 aa)
PDE1APhosphodiesterase. (623 aa)
NTPCRNucleoside-triphosphatase. (190 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.