(11 nodes) Purine nucleobase catabolic process, and Ribonucleoside biosynthetic process network (Gallus gallus)

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Your Input:
	PRTFDC1	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (226 aa)
	MTAP	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates. (280 aa)
	XDH	Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. (1358 aa)
	LOC101747367	Uncharacterized protein. (353 aa)
	EPHX2	AB hydrolase-1 domain-containing protein. (596 aa)
	LOC770996	FAD-binding PCMH-type domain-containing protein. (440 aa)
	ADAL	A_deaminase domain-containing protein. (363 aa)
	LOC100858814	Pribosyltran domain-containing protein. (210 aa)
	GDA	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family. (450 aa)
	URAH	TR_THY domain-containing protein. (213 aa)
	DALRD3	DALR anticodon binding domain containing 3. (640 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADAL	EPHX2	ENSGALP00000038578	ENSGALP00000026689	A_deaminase domain-containing protein.	AB hydrolase-1 domain-containing protein.	0.916
ADAL	LOC100858814	ENSGALP00000038578	ENSGALP00000042557	A_deaminase domain-containing protein.	Pribosyltran domain-containing protein.	0.649
ADAL	MTAP	ENSGALP00000038578	ENSGALP00000013273	A_deaminase domain-containing protein.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.537
ADAL	PRTFDC1	ENSGALP00000038578	ENSGALP00000012455	A_deaminase domain-containing protein.	Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family.	0.449
DALRD3	EPHX2	ENSGALP00000074270	ENSGALP00000026689	DALR anticodon binding domain containing 3.	AB hydrolase-1 domain-containing protein.	0.946
DALRD3	GDA	ENSGALP00000074270	ENSGALP00000070904	DALR anticodon binding domain containing 3.	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	0.472
DALRD3	MTAP	ENSGALP00000074270	ENSGALP00000013273	DALR anticodon binding domain containing 3.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.547
EPHX2	ADAL	ENSGALP00000026689	ENSGALP00000038578	AB hydrolase-1 domain-containing protein.	A_deaminase domain-containing protein.	0.916
EPHX2	DALRD3	ENSGALP00000026689	ENSGALP00000074270	AB hydrolase-1 domain-containing protein.	DALR anticodon binding domain containing 3.	0.946
EPHX2	GDA	ENSGALP00000026689	ENSGALP00000070904	AB hydrolase-1 domain-containing protein.	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	0.538
EPHX2	LOC770996	ENSGALP00000026689	ENSGALP00000026694	AB hydrolase-1 domain-containing protein.	FAD-binding PCMH-type domain-containing protein.	0.682
EPHX2	MTAP	ENSGALP00000026689	ENSGALP00000013273	AB hydrolase-1 domain-containing protein.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.973
GDA	DALRD3	ENSGALP00000070904	ENSGALP00000074270	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	DALR anticodon binding domain containing 3.	0.472
GDA	EPHX2	ENSGALP00000070904	ENSGALP00000026689	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	AB hydrolase-1 domain-containing protein.	0.538
GDA	LOC100858814	ENSGALP00000070904	ENSGALP00000042557	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	Pribosyltran domain-containing protein.	0.430
GDA	LOC101747367	ENSGALP00000070904	ENSGALP00000014338	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	Uncharacterized protein.	0.659
GDA	MTAP	ENSGALP00000070904	ENSGALP00000013273	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.	0.665
GDA	URAH	ENSGALP00000070904	ENSGALP00000073701	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	TR_THY domain-containing protein.	0.448
GDA	XDH	ENSGALP00000070904	ENSGALP00000014144	Guanine deaminase; Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia; Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.	Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species.	0.966
LOC100858814	ADAL	ENSGALP00000042557	ENSGALP00000038578	Pribosyltran domain-containing protein.	A_deaminase domain-containing protein.	0.649