(16 nodes) Histidine metabolism, and Dipeptidase network (Gallus gallus)

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Your Input:
	DPEP2	Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (419 aa)
	UROC1	Urocanate hydratase 1. (555 aa)
	SPRY3	Sprouty-like protein 3. (291 aa)
	AMDHD1	Amidohydrolase domain containing 1. (435 aa)
	CNDP1	Carnosine dipeptidase 1. (493 aa)
	CARNMT1	Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His). (449 aa)
	CARNS1	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine. (930 aa)
	POU4F3-2	Brain-specific homeobox/POU domain protein 3; May play a role in specifying terminally differentiated neuronal phenotypes; Belongs to the POU transcription factor family. Class-4 subfamily. (341 aa)
	LOC771456	Carnosine N-methyltransferase 2; N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. (322 aa)
	DPEP1	Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. (527 aa)
	CNDP2	M20_dimer domain-containing protein. (488 aa)
	ACY1	M20_dimer domain-containing protein. (413 aa)
	SLC6A6	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (708 aa)
	APBB1IP	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling; Belongs to the MRL family. (670 aa)
	HAL	Histidine ammonia-lyase; Belongs to the PAL/histidase family. (660 aa)
	TMLHE	Trimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML). (418 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACY1	DPEP1	ENSGALP00000063067	ENSGALP00000056553	M20_dimer domain-containing protein.	Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.	0.724
ACY1	DPEP2	ENSGALP00000063067	ENSGALP00000005425	M20_dimer domain-containing protein.	Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.	0.724
AMDHD1	HAL	ENSGALP00000018600	ENSGALP00000071595	Amidohydrolase domain containing 1.	Histidine ammonia-lyase; Belongs to the PAL/histidase family.	0.960
AMDHD1	UROC1	ENSGALP00000018600	ENSGALP00000010182	Amidohydrolase domain containing 1.	Urocanate hydratase 1.	0.984
APBB1IP	SLC6A6	ENSGALP00000069079	ENSGALP00000065762	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling; Belongs to the MRL family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.494
APBB1IP	SPRY3	ENSGALP00000069079	ENSGALP00000012035	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling; Belongs to the MRL family.	Sprouty-like protein 3.	0.619
APBB1IP	TMLHE	ENSGALP00000069079	ENSGALP00000072195	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling; Belongs to the MRL family.	Trimethyllysine dioxygenase, mitochondrial; Converts trimethyllysine (TML) into hydroxytrimethyllysine (HTML).	0.737
APBB1IP	UROC1	ENSGALP00000069079	ENSGALP00000010182	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein; Appears to function in the signal transduction from Ras activation to actin cytoskeletal remodeling; Belongs to the MRL family.	Urocanate hydratase 1.	0.756
CARNMT1	CARNS1	ENSGALP00000032180	ENSGALP00000055051	Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	0.944
CARNMT1	CNDP1	ENSGALP00000032180	ENSGALP00000022230	Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).	Carnosine dipeptidase 1.	0.912
CARNMT1	CNDP2	ENSGALP00000032180	ENSGALP00000058618	Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).	M20_dimer domain-containing protein.	0.922
CARNMT1	LOC771456	ENSGALP00000032180	ENSGALP00000056487	Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).	Carnosine N-methyltransferase 2; N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles.	0.900
CARNS1	CARNMT1	ENSGALP00000055051	ENSGALP00000032180	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	Carnosine N-methyltransferase; N-methyltransferase that catalyzes the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles. Also methylates other L-histidine-containing di- and tripeptides such as Gly-Gly-His, Gly-His and homocarnosine (GABA-His).	0.944
CARNS1	CNDP1	ENSGALP00000055051	ENSGALP00000022230	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	Carnosine dipeptidase 1.	0.967
CARNS1	CNDP2	ENSGALP00000055051	ENSGALP00000058618	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	M20_dimer domain-containing protein.	0.940
CARNS1	DPEP1	ENSGALP00000055051	ENSGALP00000056553	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.	0.843
CARNS1	DPEP2	ENSGALP00000055051	ENSGALP00000005425	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	Dipeptidase; Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.	0.843
CARNS1	HAL	ENSGALP00000055051	ENSGALP00000071595	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	Histidine ammonia-lyase; Belongs to the PAL/histidase family.	0.902
CARNS1	LOC771456	ENSGALP00000055051	ENSGALP00000056487	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	Carnosine N-methyltransferase 2; N-methyltransferase that mediates the formation of anserine (beta-alanyl-N(Pi)-methyl-L-histidine) from carnosine. Anserine, a methylated derivative of carnosine (beta-alanyl-L-histidine), is an abundant constituent of vertebrate skeletal muscles.	0.983
CARNS1	SLC6A6	ENSGALP00000055051	ENSGALP00000065762	Carnosine synthase 1; Catalyzes the synthesis of carnosine and homocarnosine. Carnosine is synthesized more efficiently than homocarnosine.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.616