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| | FANCA | Fanconi_A_N domain-containing protein. (1653 aa) |
| | RPA2 | RPA_C domain-containing protein. (267 aa) |
| | CDC45 | Cell division cycle 45. (566 aa) |
| | FANCG | Uncharacterized protein. (648 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (273 aa) |
| | CLSPN | Uncharacterized protein. (1337 aa) |
| | RECQL5 | Uncharacterized protein. (1052 aa) |
| | FANCE | FA_FANCE domain-containing protein. (244 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2660 aa) |
| | BRCA1 | Uncharacterized protein. (1749 aa) |
| | ERCC4 | ERCC4 domain-containing protein. (903 aa) |
| | RPA1 | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (614 aa) |
| | ATAD5 | AAA domain-containing protein. (1816 aa) |
| | MPHOSPH9 | Uncharacterized protein. (698 aa) |
| | PMS2 | Mismatch repair endonuclease PMS2; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (869 aa) |
| | BARD1 | Uncharacterized protein. (795 aa) |
| | FANCF | FA complementation group F. (391 aa) |
| | FANCD2 | Uncharacterized protein. (1510 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by [...] (992 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] (211 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1020 aa) |
| | MCM2 | DNA helicase; Belongs to the MCM family. (929 aa) |
| | CDC7 | Cell division cycle 7. (564 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1341 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1307 aa) |
| | ERCC6 | ERCC excision repair 6, chromatin remodeling factor. (1495 aa) |
| | GINS1 | Sld5 domain-containing protein. (195 aa) |
| | XPC | XPC complex subunit, DNA damage recognition and repair factor. (830 aa) |
| | TM4SF19 | Uncharacterized protein. (220 aa) |
| | FANCI | Uncharacterized protein. (1339 aa) |
| | RMI2 | RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. (137 aa) |
| | POLE | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2290 aa) |
| | EME1 | Essential meiotic structure-specific endonuclease 1. (568 aa) |
| | ORC2 | Uncharacterized protein. (569 aa) |
| | BLM | Bloom syndrome protein homolog; ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction. Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair (By similarity). Negatively regulates sister chromatid exchange (SCE) (By similarity). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity). Binds DNA. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Belongs to the helicase family. R [...] (1380 aa) |
| | RAD18 | Uncharacterized protein. (672 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (942 aa) |
| | DBF4 | DBF4 zinc finger. (709 aa) |
| | RADX | RPA1 related single stranded DNA binding protein, X-linked. (852 aa) |
| | SLX4IP | Uncharacterized protein. (439 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (617 aa) |
| | MCM8 | DNA helicase MCM8; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. (830 aa) |
| | EXD2 | 3'-5' exonuclease domain-containing protein. (621 aa) |
| | MLH3 | MutL homolog 3. (1446 aa) |
| | ORC1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (867 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | EXO1 | Uncharacterized protein. (800 aa) |
| | NHEJ1 | Non-homologous end joining factor 1. (298 aa) |
| | MSH4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (878 aa) |
| | RPL37A | Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (966 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (420 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1691 aa) |
| | ORC4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (530 aa) |
| | MCM5 | DNA helicase; Belongs to the MCM family. (734 aa) |
| | RMI1 | RecQ-mediated genome instability protein 1; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A- mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). (627 aa) |
| | FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (559 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (562 aa) |
| | MCM4 | DNA helicase; Belongs to the MCM family. (859 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (661 aa) |
| | RHNO1 | Uncharacterized protein. (264 aa) |
| | GMNN | Uncharacterized protein. (224 aa) |
| | CDT1 | Chromatin licensing and DNA replication factor 1. (745 aa) |
| | DCLRE1C | Protein artemis; Required for V(D)J recombination, the process by which exons encoding the antigen-binding domains of immunoglobulins and T-cell receptor proteins are assembled from individual V, (D), and J gene segments. V(D)J recombination is initiated by the lymphoid specific RAG endonuclease complex, which generates site specific DNA double strand breaks (DSBs). These DSBs present two types of DNA end structures: hairpin sealed coding ends and phosphorylated blunt signal ends. These ends are independently repaired by the non homologous end joining (NHEJ) pathway to form coding and [...] (714 aa) |
| | RFC1 | Replication factor C subunit 1. (1147 aa) |
| | MCM9 | DNA helicase MCM9; Component of the MCM8-MCM9 complex, a complex involved in homologous recombination repair following DNA interstrand cross-links and plays a key role during gametogenesis. The MCM8-MCM9 complex probably acts as a hexameric helicase required to process aberrant forks into homologous recombination substrates and to orchestrate homologous recombination with resection, fork stabilization and fork restart. (1169 aa) |
| | POLQ | DNA polymerase theta. (2489 aa) |
| | POLK | DNA polymerase kappa. (867 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (912 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3167 aa) |
| | RAD23B | RAD23 homolog B, nucleotide excision repair protein. (504 aa) |
| | MSH3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1090 aa) |
| | XRCC4 | X-ray repair cross complementing 4. (334 aa) |
| | ORC3 | ORC_WH_C domain-containing protein. (713 aa) |
| | PRIM2 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (508 aa) |
| | GEN1 | GEN1 Holliday junction 5' flap endonuclease. (941 aa) |
| | FANCB | Uncharacterized protein. (965 aa) |
| | MCM3 | DNA replication licensing factor MCM3; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (812 aa) |
| | LIG4 | DNA ligase 4; Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. (912 aa) |
| | ERCC5 | Uncharacterized protein. (1118 aa) |
| | BIVM | Uncharacterized protein. (505 aa) |
| | TDRD3 | Tudor domain-containing protein 3; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By simil [...] (741 aa) |
| | RFC3 | AAA domain-containing protein. (356 aa) |
| | BRCA2 | Tower domain-containing protein. (3397 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3050 aa) |
| | MRE11 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] (709 aa) |
| | MCM6 | DNA helicase; Belongs to the MCM family. (825 aa) |
| | DCLRE1A | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. (972 aa) |
| | RAD54L | DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (804 aa) |
| | MCMBP | Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion (By similarity). (634 aa) |
| | BRIP1 | Fanconi anemia group J protein homolog; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway of DNA repair, after FANCD2 ubiquitination. Probably not involved in the repair of DNA double-strand breaks by homologous recombination; Belongs to the DEAD box helicase family. DEAH subfamily. (1252 aa) |
| | ZSWIM7 | SWIM-type domain-containing protein. (140 aa) |
| | MSH6 | DNA mismatch repair protein Msh6; Component of the post-replicative DNA mismatch repair system (MMR). Involved in B cell growth by positively regulating B cell proliferation and controlling replication efficiency. Controls cell cycle to prevent re-replication and defects in DNA damage-induced G2 checkpoint. Doesn't seem to counteract or control the immunoglobulin gene conversion (Ig GC) and to contribute to guanine/uracil mismatch repair. (1342 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1313 aa) |
| | POLE3 | CBFD_NFYB_HMF domain-containing protein. (143 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (279 aa) |
| | HES1 | Transcription factor HES-1. (257 aa) |
| | XPA | DNA repair protein complementing XP-A cells homolog; Involved in DNA excision repair. Initiates repair by binding to damaged sites with various affinities, depending on the photoproduct and the transcriptional state of the region (By similarity). Belongs to the XPA family. (270 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (234 aa) |
| | RAD9A | Rad9. (376 aa) |
| | CHTF18 | AAA domain-containing protein. (951 aa) |
| | EEPD1 | Endonuclease/exonuclease/phosphatase family domain containing 1. (558 aa) |
| | POLE4 | DNA polymerase epsilon 4, accessory subunit. (146 aa) |
| | TIPIN | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Important for cell survival after DNA damage or replication stress. May be required fin the replication checkpoint induced by hydroxyurea or ultraviolet light (By similarity). (283 aa) |
| | PAXIP1 | PAX interacting protein 1. (1098 aa) |
| | PRIM1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (431 aa) |
| | MLH1 | DNA mismatch repair protein MLH1. (757 aa) |
| | RAD51 | DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. (339 aa) |
| | FEN1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (381 aa) |
| | RAD23A | RAD23 homolog A, nucleotide excision repair protein. (362 aa) |
| | LOC101748521 | DNA_MISMATCH_REPAIR_2 domain-containing protein. (809 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1907 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1519 aa) |
| | RAD51C | RAD51 paralog C. (360 aa) |
| | POLA2 | Pol_alpha_B_N domain-containing protein. (402 aa) |
| | SLX4 | SLX4 structure-specific endonuclease subunit. (1740 aa) |
| | DSCC1 | DNA replication and sister chromatid cohesion 1. (304 aa) |
| | RAD51D | RECA_2 domain-containing protein. (327 aa) |
| | ORC6 | Uncharacterized protein. (402 aa) |
| | CHEK2 | Uncharacterized protein. (524 aa) |
| | WDHD1 | WD repeat and HMG-box DNA binding protein 1. (1123 aa) |
| | POLE2 | DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (555 aa) |
| | LOC101748706 | Uncharacterized protein. (2151 aa) |
| | PWWP2A | PWWP domain containing 2A. (787 aa) |
| | CHTF8 | Uncharacterized protein. (156 aa) |
| | RAD54B | DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (918 aa) |
| | RFC2 | Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). (359 aa) |
| | XRCC6 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] (647 aa) |
| | RNASEH2B | Uncharacterized protein. (307 aa) |
| | ATRIP | Uncharacterized protein. (822 aa) |
| | FANCL | Fanconi anemia protein FANCL. (373 aa) |
| | GINS2 | DNA replication complex GINS protein PSF2; Belongs to the GINS2/PSF2 family. (185 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (284 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] (753 aa) |
| | ZRANB3-2 | HNH domain-containing protein. (442 aa) |
| | MCM10 | Minichromosome maintenance 10 replication initiation factor. (705 aa) |
| | GINS3 | GINS complex subunit 3. (214 aa) |
| | PMS1 | HMG box domain-containing protein. (916 aa) |
| | FAAP100 | Uncharacterized protein. (917 aa) |
| | HES4 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). (290 aa) |
| | PRKDC | DNA-dependent protein kinase catalytic subunit; Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA nonhomologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act a [...] (4132 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (382 aa) |
| | RFC5 | Replication factor C subunit 5. (392 aa) |
| | RFC4 | AAA domain-containing protein. (362 aa) |
| | RAD52 | DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity). (422 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa) |
| | ENSGALP00000065015 | DNA_pol_E_B domain-containing protein. (141 aa) |
| | PRIMPOL | DNA-directed primase/polymerase protein; DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesio [...] (574 aa) |
| | ENSGALP00000065485 | GIY-YIG domain-containing protein. (71 aa) |
| | FAAP24 | Uncharacterized protein. (215 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion; Belongs to the DNA polymerase type-Y family. (1276 aa) |
| | C9orf142 | Uncharacterized protein. (505 aa) |
| | CDC6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (554 aa) |
| | POLA1 | DNA polymerase. (1496 aa) |
| | RAD9B | RAD9 checkpoint clamp component B. (312 aa) |
| | LOC107049018 | Uncharacterized protein. (309 aa) |
| | XRCC5 | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (711 aa) |
| | ENSGALP00000068677 | Uncharacterized protein. (166 aa) |
| | WRN | Uncharacterized protein. (1622 aa) |
| | LIG1 | DNA ligase 1; Belongs to the ATP-dependent DNA ligase family. (961 aa) |
| | RNASEH2A | Ribonuclease; Endonuclease that specifically degrades the RNA of RNA-DNA hybrids; Belongs to the RNase HII family. (477 aa) |
| | RAD51B | RAD51 paralog B. (415 aa) |
| | ENSGALP00000069303 | Uncharacterized protein. (178 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (981 aa) |
| | FANCM | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa) |
| | FBXO18 | F-box DNA helicase 1; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: p [...] (1021 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1034 aa) |
| | RAD17 | Uncharacterized protein. (735 aa) |
| | TIMELESS | Timeless circadian regulator. (1264 aa) |
| | ERCC8 | ERCC excision repair 8, CSA ubiquitin ligase complex subunit. (399 aa) |
| | ORC5 | AAA_16 domain-containing protein. (459 aa) |
