Your Input: | |
| | FANCA | Fanconi_A_N domain-containing protein. (1653 aa) |
| | RPA2 | RPA_C domain-containing protein. (267 aa) |
| | FANCG | Uncharacterized protein. (648 aa) |
| | RECQL5 | Uncharacterized protein. (1052 aa) |
| | FANCE | FA_FANCE domain-containing protein. (244 aa) |
| | ATR | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2660 aa) |
| | BRCA1 | Uncharacterized protein. (1749 aa) |
| | RPA1 | Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (614 aa) |
| | BARD1 | Uncharacterized protein. (795 aa) |
| | FANCF | FA complementation group F. (391 aa) |
| | FANCD2 | Uncharacterized protein. (1510 aa) |
| | DNA2 | DNA replication ATP-dependent helicase/nuclease DNA2; Key enzyme involved in DNA replication and DNA repair in nucleus and mitochondrion. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA, while the 3'-ssDNA cleavage is prevented by [...] (992 aa) |
| | MAD2L2 | Mitotic spindle assembly checkpoint protein MAD2B; Adapter protein able to interact with different proteins and involved in different biological processes. Mediates the interaction between the error-prone DNA polymerase zeta catalytic subunit REV3L and the inserter polymerase REV1, thereby mediating the second polymerase switching in translesion DNA synthesis. Translesion DNA synthesis releases the replication blockade of replicative polymerases, stalled in presence of DNA lesions. May also play a role in signal transduction in response to DNA damage. May regulate the activation of the [...] (211 aa) |
| | TOP3A | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1020 aa) |
| | PALB2 | Partner and localizer of BRCA2. (1341 aa) |
| | RTEL1 | Regulator of telomere elongation helicase 1; ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by [...] (1307 aa) |
| | FANCI | Uncharacterized protein. (1339 aa) |
| | RMI2 | RecQ-mediated genome instability protein 2; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates. It is required to regulate sister chromatid segregation and to limit DNA crossover. Essential for the stability, localization, and function of BLM, TOP3A, and complexes containing BLM. In the RMI complex, it is required to target BLM to chromatin and stress-induced nuclear foci and mitotic phosphorylation of BLM. (137 aa) |
| | BLM | Bloom syndrome protein homolog; ATP-dependent DNA helicase that unwinds single- and double- stranded DNA in a 3'-5' direction. Participates in DNA replication and repair (By similarity). Involved in 5'-end resection of DNA during double-strand break (DSB) repair (By similarity). Negatively regulates sister chromatid exchange (SCE) (By similarity). Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (By similarity). Binds DNA. Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (By similarity). Belongs to the helicase family. R [...] (1380 aa) |
| | RAD18 | Uncharacterized protein. (672 aa) |
| | RADX | RPA1 related single stranded DNA binding protein, X-linked. (852 aa) |
| | PIF1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (617 aa) |
| | EXD2 | 3'-5' exonuclease domain-containing protein. (621 aa) |
| | RPA3 | Replication protein A3. (121 aa) |
| | EXO1 | Uncharacterized protein. (800 aa) |
| | RPL37A | Uncharacterized protein; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (966 aa) |
| | ZRANB3 | Zinc finger RANBP2-type containing 3. (420 aa) |
| | SHPRH | SNF2 histone linker PHD RING helicase. (1691 aa) |
| | RMI1 | RecQ-mediated genome instability protein 1; Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A- mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability (By similarity). (627 aa) |
| | FANCC | Fanconi anemia group C protein homolog; DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1. (559 aa) |
| | WRNIP1 | WRN helicase interacting protein 1. (562 aa) |
| | RECQL | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (661 aa) |
| | RHNO1 | Uncharacterized protein. (264 aa) |
| | POLQ | DNA polymerase theta. (2489 aa) |
| | POLK | DNA polymerase kappa. (867 aa) |
| | RBBP8 | RB binding protein 8, endonuclease. (912 aa) |
| | REV3L | REV3 like, DNA directed polymerase zeta catalytic subunit. (3167 aa) |
| | FANCB | Uncharacterized protein. (965 aa) |
| | TDRD3 | Tudor domain-containing protein 3; Scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In nucleus, acts as a coactivator: recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In cytoplasm, may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins (By simil [...] (741 aa) |
| | BRCA2 | Tower domain-containing protein. (3397 aa) |
| | ATM | Non-specific serine/threonine protein kinase. (3050 aa) |
| | MRE11 | Double-strand break repair protein MRE11; Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restr [...] (709 aa) |
| | DCLRE1A | DNA cross-link repair 1A protein; May be required for DNA interstrand cross-link repair. (972 aa) |
| | RAD54L | DNA repair and recombination protein RAD54-like; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (804 aa) |
| | BRIP1 | Fanconi anemia group J protein homolog; DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the 'Fanconi anemia' pathway of DNA repair, after FANCD2 ubiquitination. Probably not involved in the repair of DNA double-strand breaks by homologous recombination; Belongs to the DEAD box helicase family. DEAH subfamily. (1252 aa) |
| | RAD50 | Zinc-hook domain-containing protein. (1313 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (279 aa) |
| | HES1 | Transcription factor HES-1. (257 aa) |
| | UBE2T | Ubiquitin conjugating enzyme E2 T; Belongs to the ubiquitin-conjugating enzyme family. (234 aa) |
| | RAD9A | Rad9. (376 aa) |
| | PAXIP1 | PAX interacting protein 1. (1098 aa) |
| | RAD51 | DNA repair protein RAD51 homolog 1; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. (339 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1907 aa) |
| | TOPBP1 | DNA topoisomerase II binding protein 1. (1519 aa) |
| | RAD51C | RAD51 paralog C. (360 aa) |
| | RAD51D | RECA_2 domain-containing protein. (327 aa) |
| | CHEK2 | Uncharacterized protein. (524 aa) |
| | LOC101748706 | Uncharacterized protein. (2151 aa) |
| | PWWP2A | PWWP domain containing 2A. (787 aa) |
| | RAD54B | DNA repair and recombination protein RAD54B; Involved in DNA repair and mitotic recombination; Belongs to the SNF2/RAD54 helicase family. (918 aa) |
| | ATRIP | Uncharacterized protein. (822 aa) |
| | FANCL | Fanconi anemia protein FANCL. (373 aa) |
| | RAD1 | RAD1 checkpoint DNA exonuclease. (281 aa) |
| | HUS1 | Checkpoint protein; Belongs to the HUS1 family. (284 aa) |
| | NBN | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. The complex possesses single-strand endonuclease activity and double-strand- specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. NBN modulate the DNA damage signal sensing by recr [...] (753 aa) |
| | ZRANB3-2 | HNH domain-containing protein. (442 aa) |
| | FAAP100 | Uncharacterized protein. (917 aa) |
| | HES4 | Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). (290 aa) |
| | XRCC3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (382 aa) |
| | RAD52 | DNA repair protein RAD52 homolog; Involved in double-stranded break repair. Plays a central role in genetic recombination and DNA repair by promoting the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity). (422 aa) |
| | PRIMPOL | DNA-directed primase/polymerase protein; DNA primase and DNA polymerase required to tolerate replication-stalling lesions by bypassing them. Required to facilitate mitochondrial and nuclear replication fork progression by initiating de novo DNA synthesis using dNTPs and acting as an error-prone DNA polymerase able to bypass certain DNA lesions. Shows a high capacity to tolerate DNA damage lesions such as 8oxoG and abasic sites in DNA (By similarity). Provides different translesion synthesis alternatives when DNA replication is stalled: able to synthesize DNA primers downstream of lesio [...] (574 aa) |
| | ENSGALP00000065485 | GIY-YIG domain-containing protein. (71 aa) |
| | FAAP24 | Uncharacterized protein. (215 aa) |
| | TOP3B | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (862 aa) |
| | REV1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents (By similarity). May play a role in homologous recombination and immunoglobulin gene conversion; Belongs to the DNA polymerase type-Y family. (1276 aa) |
| | RAD9B | RAD9 checkpoint clamp component B. (312 aa) |
| | LOC107049018 | Uncharacterized protein. (309 aa) |
| | WRN | Uncharacterized protein. (1622 aa) |
| | RAD51B | RAD51 paralog B. (415 aa) |
| | SLF1 | SMC5-SMC6 complex localization factor 1. (981 aa) |
| | FANCM | Fanconi anemia group M protein; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (By similarity). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double- stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (By similarity). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a mova [...] (2101 aa) |
| | FBXO18 | F-box DNA helicase 1; 3'-5' DNA helicase and substrate-recognition component of the SCF(FBH1) E3 ubiquitin ligase complex that plays a key role in response to stalled/damaged replication forks (By similarity). Involved in genome maintenance by acting as an anti-recombinogenic helicase and preventing extensive strand exchange during homologous recombination: promotes RAD51 filament dissolution from stalled forks, thereby inhibiting homologous recombination and preventing excessive recombination. Also promotes cell death and DNA double-strand breakage in response to replication stress: p [...] (1021 aa) |
| | FAN1 | Fanconi-associated nuclease; Nuclease required for the repair of DNA interstrand cross- links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions. Belongs to the FAN1 family. (1034 aa) |
