(5 nodes) Positive regulation of double-strand break repair via nonhomologous end joining, and Negative regulation of DNA recombination network (Gallus gallus)

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Your Input:
	RIF1	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity). (2168 aa)
	SHLD2	Shieldin complex subunit 2. (895 aa)
	SHLD3	Shieldin complex subunit 3. (249 aa)
	SHLD1	Shieldin complex subunit 1. (240 aa)
	ASTE1	Uncharacterized protein. (215 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ASTE1	RIF1	ENSGALP00000069552	ENSGALP00000036991	Uncharacterized protein.	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).	0.786
ASTE1	SHLD2	ENSGALP00000069552	ENSGALP00000040968	Uncharacterized protein.	Shieldin complex subunit 2.	0.426
RIF1	ASTE1	ENSGALP00000036991	ENSGALP00000069552	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).	Uncharacterized protein.	0.786
RIF1	SHLD1	ENSGALP00000036991	ENSGALP00000065910	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).	Shieldin complex subunit 1.	0.749
RIF1	SHLD2	ENSGALP00000036991	ENSGALP00000040968	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).	Shieldin complex subunit 2.	0.842
RIF1	SHLD3	ENSGALP00000036991	ENSGALP00000046721	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).	Shieldin complex subunit 3.	0.740
SHLD1	RIF1	ENSGALP00000065910	ENSGALP00000036991	Shieldin complex subunit 1.	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).	0.749
SHLD1	SHLD2	ENSGALP00000065910	ENSGALP00000040968	Shieldin complex subunit 1.	Shieldin complex subunit 2.	0.997
SHLD1	SHLD3	ENSGALP00000065910	ENSGALP00000046721	Shieldin complex subunit 1.	Shieldin complex subunit 3.	0.959
SHLD2	ASTE1	ENSGALP00000040968	ENSGALP00000069552	Shieldin complex subunit 2.	Uncharacterized protein.	0.426
SHLD2	RIF1	ENSGALP00000040968	ENSGALP00000036991	Shieldin complex subunit 2.	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).	0.842
SHLD2	SHLD1	ENSGALP00000040968	ENSGALP00000065910	Shieldin complex subunit 2.	Shieldin complex subunit 1.	0.997
SHLD2	SHLD3	ENSGALP00000040968	ENSGALP00000046721	Shieldin complex subunit 2.	Shieldin complex subunit 3.	0.989
SHLD3	RIF1	ENSGALP00000046721	ENSGALP00000036991	Shieldin complex subunit 3.	Telomere-associated protein RIF1; Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM- phosphorylated TP53BP1, allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract DSBs resection via homologous recombination (HR) during G1 phase (By similarity).	0.740
SHLD3	SHLD1	ENSGALP00000046721	ENSGALP00000065910	Shieldin complex subunit 3.	Shieldin complex subunit 1.	0.959
SHLD3	SHLD2	ENSGALP00000046721	ENSGALP00000040968	Shieldin complex subunit 3.	Shieldin complex subunit 2.	0.989