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| | STK38 | Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (465 aa) |
| | FAM72A | Uncharacterized protein. (120 aa) |
| | NCAPD3 | Condensin-2 complex subunit D3; Regulatory subunit of the condensin-2 complex, a complex which establishes mitotic chromosome architecture and is involved in physical rigidity of the chromatid axis. (1453 aa) |
| | PTTG2 | Uncharacterized protein. (193 aa) |
| | CCNG1 | Cyclin G1; Belongs to the cyclin family. (295 aa) |
| | E2F4 | E2F transcription factor 4. (414 aa) |
| | E2F1 | Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa) |
| | CDK1 | Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa) |
| | CCND3 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa) |
| | CCNB1 | G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (399 aa) |
| | KIF4B | Chromosome-associated kinesin KIF4; Required for mitotic chromosomal positioning and bipolar spindle stabilization. (1226 aa) |
| | MAD1L1 | Mitotic arrest deficient 1 like 1. (717 aa) |
| | CCNE1 | G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. (407 aa) |
| | KNTC1 | Rod_C domain-containing protein. (398 aa) |
| | CENPP | Centromere protein P; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. (287 aa) |
| | CDC14A | Uncharacterized protein. (603 aa) |
| | FAM64A | Uncharacterized protein. (291 aa) |
| | PLK1 | Serine/threonine-protein kinase PLK. (595 aa) |
| | TPX2 | Uncharacterized protein. (738 aa) |
| | NCAPG2 | Non-SMC condensin II complex subunit G2. (1144 aa) |
| | CEP55 | Centrosomal protein 55. (465 aa) |
| | CCNJ | Cyclin J; Belongs to the cyclin family. (383 aa) |
| | INCENP | Inner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central [...] (877 aa) |
| | CCND1 | G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa) |
| | ZWILCH | Zwilch kinetochore protein. (536 aa) |
| | BUB1 | Uncharacterized protein. (1087 aa) |
| | NUSAP1 | Nucleolar and spindle-associated protein 1; Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity). (501 aa) |
| | ECT2 | Epithelial cell transforming 2. (914 aa) |
| | CDK6 | Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa) |
| | CENPF | Uncharacterized protein. (2935 aa) |
| | NEK2 | Protein kinase domain-containing protein. (444 aa) |
| | CDC20 | WD_REPEATS_REGION domain-containing protein. (507 aa) |
| | KIF2C | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (733 aa) |
| | CBWD1 | CobW C-terminal domain-containing protein. (370 aa) |
| | PLK4 | POLO box domain-containing protein. (566 aa) |
| | CCNG2 | Cyclin G2. (259 aa) |
| | CDKN2C | Cyclin dependent kinase inhibitor 2C. (167 aa) |
| | SPC25 | Uncharacterized protein. (234 aa) |
| | LIN54 | Lin-54 DREAM MuvB core complex component. (804 aa) |
| | LOC429032 | Rho-GAP domain-containing protein. (568 aa) |
| | CENPC | Uncharacterized protein. (872 aa) |
| | CCNA2 | Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (395 aa) |
| | CENPM | Centromere protein M; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. (177 aa) |
| | DLGAP5 | DLG associated protein 5. (833 aa) |
| | CDKN3 | Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. (207 aa) |
| | PARPBP | PCNA-interacting partner; Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability; Belongs to the PARI family. (583 aa) |
| | PRC1 | Uncharacterized protein. (261 aa) |
| | WEE2 | Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry (By similarity). (556 aa) |
| | CENPE | Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2228 aa) |
| | FOXM1 | Fork-head domain-containing protein. (795 aa) |
| | CDCA3 | Uncharacterized protein. (235 aa) |
| | PLK2 | Serine/threonine-protein kinase PLK. (671 aa) |
| | CENPK | Centromere protein K; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. (362 aa) |
| | NDC80 | Kinetochore protein NDC80 homolog; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. May play a role in chromosome congression and may be essential for the end-on attachment of the kinetochores t [...] (640 aa) |
| | TTK | TTK protein kinase. (880 aa) |
| | MIS18A | MIS18 kinetochore protein A. (204 aa) |
| | PBK | Protein kinase domain-containing protein. (322 aa) |
| | CENPO | Centromere protein O; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). Involved in kinetochore assembly and required for recovery from spindle damage; Belongs to the CENP-O/MCM21 family. (325 aa) |
| | CCNA1 | Cyclin A1; Belongs to the cyclin family. (406 aa) |
| | CCND2 | G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily. (291 aa) |
| | CDK3 | Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (309 aa) |
| | CENPU | Centromere protein U; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for maintenance of sister chromatid adhesion during mitotic checkpoint activation. (345 aa) |
| | CENPH | Centromere protein H; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex; Belongs to the CENP-H/MCM16 family. (235 aa) |
| | SMC4 | Structural maintenance of chromosomes protein. (1300 aa) |
| | AURKA | Aurora kinase A; Belongs to the protein kinase superfamily. (409 aa) |
| | CENPQ | Centromere protein Q; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May play an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores. Belongs to the CENP-Q/OKP1 family. (283 aa) |
| | KIF20AL | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (632 aa) |
| | CDKN1B | Cyclin-dependent kinase inhibitor p27 Kip1. (198 aa) |
| | E2F3 | E2F transcription factor 3. (341 aa) |
| | OIP5 | Mis18 domain-containing protein. (213 aa) |
| | NSL1 | Nsl1 protein. (290 aa) |
| | BIRC5 | Uncharacterized protein. (142 aa) |
| | CENPN | Centromere protein N; Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation; Belongs to the CENP-N/CHL4 family. (352 aa) |
| | NUF2 | Kinetochore protein Nuf2; Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity. Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore (By similarity). The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules (By similarity); Belongs to the NUF2 family. (469 aa) |
| | CCNI2 | Cyclin I family member 2; Belongs to the cyclin family. (259 aa) |
| | CENPS | Centromere protein S; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPX (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP- dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPX and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked re [...] (139 aa) |
| | GAS2L3 | Uncharacterized protein. (726 aa) |
| | ITGB3BP | Centromere protein R; Transcription coregulator that can have both coactivator and corepressor functions. Involved in the coactivation of nuclear receptors for retinoid X (RXRs) and thyroid hormone (TRs) in a ligand- dependent fashion. Probable component of a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). (179 aa) |
| | MAD2L1BP | MAD2L1 binding protein. (282 aa) |
| | ARHGAP11B | Rho-GAP domain-containing protein. (996 aa) |
| | CENPW | Centromere protein W; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] (76 aa) |
| | WEE1 | Wee1-like protein kinase. (641 aa) |
| | UBE2C | Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa) |
| | CCNE2 | Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa) |
| | CENPA | Histone H3-like centromeric protein A; Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. The presence of CENPA subtly modifies the nucleosome structure and the way DNA is wrapped around the nucleosome and gives rise to protruding DNA ends that are less well- ordered and rigid compared to nucleosomes containing histone H3. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By simil [...] (131 aa) |
| | KIF11 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1065 aa) |
| | C1orf112 | Chromosome 1 open reading frame 112. (859 aa) |
| | KIF20BL | Uncharacterized protein. (441 aa) |
| | KIF20B | Uncharacterized protein. (659 aa) |
| | MYBL2 | Myb-related protein B; Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family. (820 aa) |
| | KIF15 | Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1402 aa) |
| | NCAPD2 | Condensin complex subunit 1; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. (1411 aa) |
| | MYB | Transcriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. (785 aa) |
| | E2F5 | E2F_TDP domain-containing protein. (375 aa) |
| | DSN1 | Dsn1 protein. (349 aa) |
| | PLK3 | Serine/threonine-protein kinase PLK. (644 aa) |
| | KNSTRN | Uncharacterized protein. (268 aa) |
| | KIAA0101 | PAF domain-containing protein. (110 aa) |
| | CDCA9 | Borealin-2; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). (287 aa) |
| | TOP2A | DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in the regulation of circadian rhythm. (1553 aa) |
| | KIF23 | Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa) |
| | INCENPL | Uncharacterized protein. (837 aa) |
| | NCAPG | Non-SMC condensin I complex subunit G. (1038 aa) |
| | CENPT | Centromere protein T; Component of the CENPA-NAC (nucleosome-associated) complex, a complex that plays a central role in assembly of kinetochore proteins, mitotic progression and chromosome segregation (By similarity). The CENPA-NAC complex recruits the CENPA-CAD (nucleosome distal) complex and may be involved in incorporation of newly synthesized CENPA into centromeres (By similarity). Part of a nucleosome-associated complex that binds specifically to histone H3-containing nucleosomes at the centromere, as opposed to nucleosomes containing CENPA. Component of the heterotetrameric CENP [...] (649 aa) |
| | CKS2 | Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa) |
| | ESPL1 | Extra spindle pole bodies like 1, separase. (2222 aa) |
| | ENSGALP00000053189 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (542 aa) |
| | ENSGALP00000053633 | Uncharacterized protein. (229 aa) |
| | ZW10 | Uncharacterized protein. (781 aa) |
| | CENPI | Centromere protein I; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. Required for the localization of CENPC but not CENPA to the centromere. It however may be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. (753 aa) |
| | BUB1B | BUB1 N-terminal domain-containing protein. (1086 aa) |
| | TFDP2 | Uncharacterized protein. (508 aa) |
| | RACGAP1 | Rac GTPase activating protein 1. (638 aa) |
| | SPC24 | Uncharacterized protein. (72 aa) |
| | CDK2 | Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | ASPM | Abnormal spindle microtubule assembly. (3296 aa) |
| | CDC14B | Uncharacterized protein. (499 aa) |
| | CDC25A | Rhodanese domain-containing protein. (526 aa) |
| | LOC107057175 | Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). (296 aa) |
| | KNL1 | Knl1_RWD_C domain-containing protein. (399 aa) |
| | MAD2L1 | HORMA domain-containing protein. (206 aa) |
| | RBL2 | Uncharacterized protein. (1259 aa) |
| | BUB3 | WD_REPEATS_REGION domain-containing protein. (392 aa) |
| | CENPL | Centromere protein L; Component of the CENPA-HI complex, a centromeric complex involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. (344 aa) |
| | MELK | Non-specific serine/threonine protein kinase. (689 aa) |
| | TMPO | Uncharacterized protein. (476 aa) |
| | TRIP13 | Pachytene checkpoint protein 2 homolog; Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways (By similarity). (432 aa) |
| | MKI67 | FHA domain-containing protein. (2570 aa) |
| | ENSGALP00000065041 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (157 aa) |
| | LOC112530990 | Uncharacterized protein. (205 aa) |
| | LIN9 | DIRP domain-containing protein. (543 aa) |
| | ANLN | Anillin actin binding protein. (1120 aa) |
| | ENSGALP00000065966 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (227 aa) |
| | SMC2 | Structural maintenance of chromosomes protein 2; Central component of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases; Belongs to the SMC family. SMC2 subfamily. (1235 aa) |
| | NNF1 | Uncharacterized protein. (279 aa) |
| | TRNP1 | Uncharacterized protein. (622 aa) |
| | ENSGALP00000067477 | Uncharacterized protein. (178 aa) |
| | E2F2 | E2F_TDP domain-containing protein. (117 aa) |
| | LIN52 | Protein lin-52 homolog. (282 aa) |
| | LOC107057183 | Nbl1_Borealin_N domain-containing protein. (257 aa) |
| | ENSGALP00000069624 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (195 aa) |
| | CDC20B | Cell division cycle 20B. (403 aa) |
| | CDCA2 | PP1-binding domain-containing protein. (872 aa) |
| | RBL1 | RB transcriptional corepressor like 1. (1050 aa) |
| | LOC107050650 | Protein kinase domain-containing protein. (153 aa) |
| | LOC101751545 | Uncharacterized protein. (189 aa) |
| | NCAPH2 | Non-SMC condensin II complex subunit H2. (727 aa) |
| | MIS18BP1 | SANT domain-containing protein. (1097 aa) |
| | RB1 | Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa) |
| | CDKN1A | Uncharacterized protein. (319 aa) |
| | CENPX | Centromere protein X; DNA-binding component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS (MHF heterodimer), crucial cofactor for FANCM in both binding and ATP-dependent remodeling of DNA. Stabilizes FANCM. In complex with CENPS and FANCM (but not other FANC proteins), rapidly recruited to blocked forks and promotes gene conversion at blocked rep [...] (115 aa) |
| | ENSGALP00000071877 | Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (208 aa) |
| | SPAG5 | Uncharacterized protein. (1431 aa) |
| | ENSGALP00000073177 | Uncharacterized protein. (95 aa) |
| | NCAPH | Condensin complex subunit 2; Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. (729 aa) |
| | ANP32E | Acidic leucine-rich nuclear phosphoprotein 32 family member E; Histone chaperone that specifically mediates the genome-wide removal of histone H2A.Z/H2AZ1 from the nucleosome: removes H2A.Z/H2AZ1 from its normal sites of deposition, especially from enhancer and insulator regions. Not involved in deposition of H2A.Z/H2AZ1 in the nucleosome. May stabilize the evicted H2A.Z/H2AZ1-H2B dimer, thus shifting the equilibrium towards dissociation and the off-chromatin state. Inhibits activity of protein phosphatase 2A (PP2A). Does not inhibit protein phosphatase 1. May play a role in cerebellar [...] (282 aa) |
