(48 nodes) Mixed, incl. Spindle midzone, and Negative regulation of sister chromatid segregation network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	PTTG2	Uncharacterized protein. (193 aa)
	CCNB1	G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition. (399 aa)
	KIF4B	Chromosome-associated kinesin KIF4; Required for mitotic chromosomal positioning and bipolar spindle stabilization. (1226 aa)
	MAD1L1	Mitotic arrest deficient 1 like 1. (717 aa)
	PLK1	Serine/threonine-protein kinase PLK. (595 aa)
	TPX2	Uncharacterized protein. (738 aa)
	CEP55	Centrosomal protein 55. (465 aa)
	INCENP	Inner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central [...] (877 aa)
	BUB1	Uncharacterized protein. (1087 aa)
	NUSAP1	Nucleolar and spindle-associated protein 1; Microtubule-associated protein with the capacity to bundle and stabilize microtubules. May associate with chromosomes and promote the organization of mitotic spindle microtubules around them (By similarity). (501 aa)
	ECT2	Epithelial cell transforming 2. (914 aa)
	CENPF	Uncharacterized protein. (2935 aa)
	NEK2	Protein kinase domain-containing protein. (444 aa)
	CDC20	WD_REPEATS_REGION domain-containing protein. (507 aa)
	KIF2C	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (733 aa)
	LOC429032	Rho-GAP domain-containing protein. (568 aa)
	DLGAP5	DLG associated protein 5. (833 aa)
	PRC1	Uncharacterized protein. (261 aa)
	CENPE	Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2228 aa)
	CDCA3	Uncharacterized protein. (235 aa)
	TTK	TTK protein kinase. (880 aa)
	PBK	Protein kinase domain-containing protein. (322 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (409 aa)
	BIRC5	Uncharacterized protein. (142 aa)
	UBE2C	Ubiquitin conjugating enzyme E2 C; Belongs to the ubiquitin-conjugating enzyme family. (179 aa)
	KIF11	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1065 aa)
	KIF15	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1402 aa)
	KNSTRN	Uncharacterized protein. (268 aa)
	KIAA0101	PAF domain-containing protein. (110 aa)
	CDCA9	Borealin-2; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). (287 aa)
	TOP2A	DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in the regulation of circadian rhythm. (1553 aa)
	KIF23	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (972 aa)
	INCENPL	Uncharacterized protein. (837 aa)
	ESPL1	Extra spindle pole bodies like 1, separase. (2222 aa)
	ENSGALP00000053633	Uncharacterized protein. (229 aa)
	BUB1B	BUB1 N-terminal domain-containing protein. (1086 aa)
	RACGAP1	Rac GTPase activating protein 1. (638 aa)
	ASPM	Abnormal spindle microtubule assembly. (3296 aa)
	LOC107057175	Borealin; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly (By similarity). (296 aa)
	MAD2L1	HORMA domain-containing protein. (206 aa)
	BUB3	WD_REPEATS_REGION domain-containing protein. (392 aa)
	MELK	Non-specific serine/threonine protein kinase. (689 aa)
	MKI67	FHA domain-containing protein. (2570 aa)
	ANLN	Anillin actin binding protein. (1120 aa)
	LOC107057183	Nbl1_Borealin_N domain-containing protein. (257 aa)
	CDC20B	Cell division cycle 20B. (403 aa)
	SPAG5	Uncharacterized protein. (1431 aa)
	ENSGALP00000073177	Uncharacterized protein. (95 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANLN	ASPM	ENSGALP00000065342	ENSGALP00000057705	Anillin actin binding protein.	Abnormal spindle microtubule assembly.	0.737
ANLN	AURKA	ENSGALP00000065342	ENSGALP00000032883	Anillin actin binding protein.	Aurora kinase A; Belongs to the protein kinase superfamily.	0.793
ANLN	BIRC5	ENSGALP00000065342	ENSGALP00000038330	Anillin actin binding protein.	Uncharacterized protein.	0.534
ANLN	BUB1	ENSGALP00000065342	ENSGALP00000013385	Anillin actin binding protein.	Uncharacterized protein.	0.729
ANLN	BUB1B	ENSGALP00000065342	ENSGALP00000055351	Anillin actin binding protein.	BUB1 N-terminal domain-containing protein.	0.588
ANLN	BUB3	ENSGALP00000065342	ENSGALP00000061487	Anillin actin binding protein.	WD_REPEATS_REGION domain-containing protein.	0.402
ANLN	CCNB1	ENSGALP00000065342	ENSGALP00000006605	Anillin actin binding protein.	G2/mitotic-specific cyclin-B2; Essential for the control of the cell cycle at the G2/M (mitosis) transition.	0.559
ANLN	CDC20	ENSGALP00000065342	ENSGALP00000016189	Anillin actin binding protein.	WD_REPEATS_REGION domain-containing protein.	0.585
ANLN	CDCA3	ENSGALP00000065342	ENSGALP00000023380	Anillin actin binding protein.	Uncharacterized protein.	0.597
ANLN	CENPE	ENSGALP00000065342	ENSGALP00000021544	Anillin actin binding protein.	Centromere protein E; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.618
ANLN	CENPF	ENSGALP00000065342	ENSGALP00000015880	Anillin actin binding protein.	Uncharacterized protein.	0.682
ANLN	CEP55	ENSGALP00000065342	ENSGALP00000010710	Anillin actin binding protein.	Centrosomal protein 55.	0.765
ANLN	DLGAP5	ENSGALP00000065342	ENSGALP00000019842	Anillin actin binding protein.	DLG associated protein 5.	0.927
ANLN	ECT2	ENSGALP00000065342	ENSGALP00000014900	Anillin actin binding protein.	Epithelial cell transforming 2.	0.871
ANLN	ENSGALP00000053633	ENSGALP00000065342	ENSGALP00000053633	Anillin actin binding protein.	Uncharacterized protein.	0.593
ANLN	INCENP	ENSGALP00000065342	ENSGALP00000012175	Anillin actin binding protein.	Inner centromere protein; Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Acts as a scaffold regulating CPC localization and activity. The C-terminus associates with AURKB, the N-terminus associated with BIRC5/survivin and CDCA8/borealin tethers the CPC to the inner centromere, and the microtubule binding activity within the central [...]	0.681
ANLN	INCENPL	ENSGALP00000065342	ENSGALP00000050943	Anillin actin binding protein.	Uncharacterized protein.	0.655
ANLN	KIF11	ENSGALP00000065342	ENSGALP00000044151	Anillin actin binding protein.	Kinesin motor domain-containing protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.930
ANLN	KIF15	ENSGALP00000065342	ENSGALP00000047407	Anillin actin binding protein.	Kinesin family member 15; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.432
ANLN	KIF23	ENSGALP00000065342	ENSGALP00000050793	Anillin actin binding protein.	Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.	0.942