STRINGSTRING
STK38 STK38 CCNG1 CCNG1 E2F4 E2F4 E2F1 E2F1 CDK1 CDK1 CCND3 CCND3 CCNE1 CCNE1 CDC14A CDC14A CCNJ CCNJ CCND1 CCND1 CDK6 CDK6 PLK4 PLK4 CCNG2 CCNG2 CDKN2C CDKN2C LIN54 LIN54 CCNA2 CCNA2 CDKN3 CDKN3 WEE2 WEE2 FOXM1 FOXM1 PLK2 PLK2 CCNA1 CCNA1 CCND2 CCND2 CDK3 CDK3 CDKN1B CDKN1B E2F3 E2F3 CCNI2 CCNI2 WEE1 WEE1 CCNE2 CCNE2 MYBL2 MYBL2 MYB MYB E2F5 E2F5 PLK3 PLK3 CKS2 CKS2 TFDP2 TFDP2 CDK2 CDK2 CDC14B CDC14B CDC25A CDC25A RBL2 RBL2 LOC112530990 LOC112530990 LIN9 LIN9 E2F2 E2F2 LIN52 LIN52 RBL1 RBL1 LOC107050650 LOC107050650 LOC101751545 LOC101751545 RB1 RB1 CDKN1A CDKN1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
STK38Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (465 aa)
CCNG1Cyclin G1; Belongs to the cyclin family. (295 aa)
E2F4E2F transcription factor 4. (414 aa)
E2F1Transcription factor E2F1; Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA bindi [...] (403 aa)
CDK1Cyclin-dependent kinase 1; Plays a key role in the control of the eukaryotic cell cycle (By similarity). It is required in higher cells for entry into S-phase and mitosis (By similarity). p34 is a component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (By similarity). May play a role in regulating the amplitude of the cyclic expression of circadian clock genes (By similarity). Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. (303 aa)
CCND3Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (292 aa)
CCNE1G1/S-specific cyclin-E1; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin E subfamily. (407 aa)
CDC14AUncharacterized protein. (603 aa)
CCNJCyclin J; Belongs to the cyclin family. (383 aa)
CCND1G1/S-specific cyclin-D1; Essential for the control of the cell cycle at the G1/S (start) transition. Interacts with the CDK4 and CDK6 protein kinases. May play a role in transcriptional regulation (By similarity). (292 aa)
CDK6Cyclin-dependent kinase; Belongs to the protein kinase superfamily. (326 aa)
PLK4POLO box domain-containing protein. (566 aa)
CCNG2Cyclin G2. (259 aa)
CDKN2CCyclin dependent kinase inhibitor 2C. (167 aa)
LIN54Lin-54 DREAM MuvB core complex component. (804 aa)
CCNA2Cyclin-A2; Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle. (395 aa)
CDKN3Cyclin-dependent kinase inhibitor 3; May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues. (207 aa)
WEE2Wee1-like protein kinase 2; Oocyte-specific protein tyrosine kinase that phosphorylates and inhibits CDK1 and acts as a key regulator of meiosis. Required to maintain meiotic arrest in oocytes by phosphorylating CDK1 at 'Tyr-15', leading to inhibit CDK1 activity and prevent meiotic reentry (By similarity). (556 aa)
FOXM1Fork-head domain-containing protein. (795 aa)
PLK2Serine/threonine-protein kinase PLK. (671 aa)
CCNA1Cyclin A1; Belongs to the cyclin family. (406 aa)
CCND2G1/S-specific cyclin-D2; Essential for the control of the cell cycle at the G1/S (start) transition; Belongs to the cyclin family. Cyclin D subfamily. (291 aa)
CDK3Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (309 aa)
CDKN1BCyclin-dependent kinase inhibitor p27 Kip1. (198 aa)
E2F3E2F transcription factor 3. (341 aa)
CCNI2Cyclin I family member 2; Belongs to the cyclin family. (259 aa)
WEE1Wee1-like protein kinase. (641 aa)
CCNE2Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa)
MYBL2Myb-related protein B; Represses v-myb- and c-myb-mediated activation of the mim-1 gene, probably by competing with other myb proteins for binding sites. It is an inhibitory member of the myb family. (820 aa)
MYBTranscriptional activator Myb; Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. (785 aa)
E2F5E2F_TDP domain-containing protein. (375 aa)
PLK3Serine/threonine-protein kinase PLK. (644 aa)
CKS2Cyclin-dependent kinases regulatory subunit; Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. (79 aa)
TFDP2Uncharacterized protein. (508 aa)
CDK2Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
CDC14BUncharacterized protein. (499 aa)
CDC25ARhodanese domain-containing protein. (526 aa)
RBL2Uncharacterized protein. (1259 aa)
LOC112530990Uncharacterized protein. (205 aa)
LIN9DIRP domain-containing protein. (543 aa)
E2F2E2F_TDP domain-containing protein. (117 aa)
LIN52Protein lin-52 homolog. (282 aa)
RBL1RB transcriptional corepressor like 1. (1050 aa)
LOC107050650Protein kinase domain-containing protein. (153 aa)
LOC101751545Uncharacterized protein. (189 aa)
RB1Retinoblastoma-associated protein; Key regulator of entry into cell division that acts as a tumor suppressor. Acts as a transcription repressor of E2F1 target genes. Directly involved in heterochromatin formation by maintaining overall chromatin structure and, in particular, that of constitutive heterochromatin by stabilizing histone methylation. Recruits and targets histone methyltransferases SUV39H1, KMT5B and KMT5C, leading to epigenetic transcriptional repression. Controls histone H4 'Lys-20' trimethylation. Also acts as a transcription repressor of E2F target genes by recruiting c [...] (984 aa)
CDKN1AUncharacterized protein. (319 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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