(7 nodes) Regulation of TP53 Activity through Association with Co-factors, and SWIB/MDM2 domain network (Gallus gallus)

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Your Input:
	MDM4	MDM4 regulator of p53. (565 aa)
	TP73	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. (660 aa)
	MDM2	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family. (483 aa)
	CDKN2B	p15INK4b tumor suppressor. (139 aa)
	TCHP	Uncharacterized protein. (373 aa)
	PPP1R13B	Protein phosphatase 1 regulatory subunit 13B. (1147 aa)
	TP63	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDKN2B	MDM2	ENSGALP00000042709	ENSGALP00000016144	p15INK4b tumor suppressor.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.924
CDKN2B	MDM4	ENSGALP00000042709	ENSGALP00000000906	p15INK4b tumor suppressor.	MDM4 regulator of p53.	0.690
MDM2	CDKN2B	ENSGALP00000016144	ENSGALP00000042709	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	p15INK4b tumor suppressor.	0.924
MDM2	MDM4	ENSGALP00000016144	ENSGALP00000000906	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	MDM4 regulator of p53.	0.999
MDM2	TCHP	ENSGALP00000016144	ENSGALP00000051549	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Uncharacterized protein.	0.628
MDM2	TP63	ENSGALP00000016144	ENSGALP00000062182	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.729
MDM2	TP73	ENSGALP00000016144	ENSGALP00000001485	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.972
MDM4	CDKN2B	ENSGALP00000000906	ENSGALP00000042709	MDM4 regulator of p53.	p15INK4b tumor suppressor.	0.690
MDM4	MDM2	ENSGALP00000000906	ENSGALP00000016144	MDM4 regulator of p53.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.999
MDM4	TCHP	ENSGALP00000000906	ENSGALP00000051549	MDM4 regulator of p53.	Uncharacterized protein.	0.478
MDM4	TP63	ENSGALP00000000906	ENSGALP00000062182	MDM4 regulator of p53.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.595
MDM4	TP73	ENSGALP00000000906	ENSGALP00000001485	MDM4 regulator of p53.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.589
PPP1R13B	TP63	ENSGALP00000057265	ENSGALP00000062182	Protein phosphatase 1 regulatory subunit 13B.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.655
PPP1R13B	TP73	ENSGALP00000057265	ENSGALP00000001485	Protein phosphatase 1 regulatory subunit 13B.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.694
TCHP	MDM2	ENSGALP00000051549	ENSGALP00000016144	Uncharacterized protein.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.628
TCHP	MDM4	ENSGALP00000051549	ENSGALP00000000906	Uncharacterized protein.	MDM4 regulator of p53.	0.478
TP63	MDM2	ENSGALP00000062182	ENSGALP00000016144	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	E3 ubiquitin-protein ligase Mdm2; Belongs to the MDM2/MDM4 family.	0.729
TP63	MDM4	ENSGALP00000062182	ENSGALP00000000906	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	MDM4 regulator of p53.	0.595
TP63	PPP1R13B	ENSGALP00000062182	ENSGALP00000057265	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	Protein phosphatase 1 regulatory subunit 13B.	0.655
TP63	TP73	ENSGALP00000062182	ENSGALP00000001485	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	Tumor protein p73; Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein.	0.980