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| | COPS2 | PCI domain-containing protein. (443 aa) |
| | SAMHD1 | Deoxynucleoside triphosphate triphosphohydrolase SAMHD1; Protein that acts both as a host restriction factor involved in defense response to virus and as a regulator of DNA end resection at stalled replication forks. Has deoxynucleoside triphosphate (dNTPase) activity, which is required to restrict infection by viruses: dNTPase activity reduces cellular dNTP levels to levels too low for retroviral reverse transcription to occur, blocking early-stage virus replication in dendritic and other myeloid cells. Functions during S phase at stalled DNA replication forks to promote the resection [...] (614 aa) |
| | COMMD4 | COMM domain-containing protein. (199 aa) |
| | CISH | Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...] (258 aa) |
| | SPSB3 | SplA/ryanodine receptor domain and SOCS box containing 3. (389 aa) |
| | COMMD10 | COMM domain-containing protein. (203 aa) |
| | FBXL16 | Uncharacterized protein. (503 aa) |
| | KCTD7 | BTB/POZ domain-containing protein KCTD7; May be involved in the control of excitability of cortical neurons. (289 aa) |
| | UBE4B | Ubiquitination factor E4B. (1346 aa) |
| | GPS1 | PCI domain-containing protein. (487 aa) |
| | TRPC4AP | Uncharacterized protein. (771 aa) |
| | KLHL11 | Kelch like family member 11. (689 aa) |
| | SKP2 | F-box domain-containing protein. (520 aa) |
| | MREG | Melanoregulin. (208 aa) |
| | ASB1 | Ankyrin repeat and SOCS box containing 1. (309 aa) |
| | FBXL18 | F-box domain-containing protein. (711 aa) |
| | DCAF10 | DDB1 and CUL4 associated factor 10. (390 aa) |
| | WSB1 | SOCS box-containing WD protein SWiP-1. (421 aa) |
| | ETV5 | ETS domain-containing protein. (507 aa) |
| | DCAF12L2 | DDB1- and CUL4-associated factor 12; May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. (427 aa) |
| | SKP1 | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa) |
| | COMMD7 | COMM domain-containing protein. (201 aa) |
| | DET1 | Uncharacterized protein. (551 aa) |
| | NEURL2 | Neuralized E3 ubiquitin protein ligase 2. (265 aa) |
| | KCTD6 | Potassium channel tetramerization domain containing 6. (237 aa) |
| | KBTBD13 | Kelch repeat and BTB domain containing 13. (452 aa) |
| | COPS7B | COP9 signalosome subunit 7B. (400 aa) |
| | COMMD3 | COMM domain containing 3. (192 aa) |
| | DDB2 | DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1- CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1- CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV [...] (507 aa) |
| | CRBN | Protein cereblon; Substrate recognition component of a DCX (DDB1-CUL4-X-box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May also play a role in the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning. (445 aa) |
| | COMMD5 | COMM domain-containing protein. (226 aa) |
| | COMMD1 | Copper metabolism domain containing 1. (215 aa) |
| | FAM45A | UDENN domain-containing protein. (397 aa) |
| | DCAF4L2 | WD_REPEATS_REGION domain-containing protein. (501 aa) |
| | DCAF5 | DDB1 and CUL4 associated factor 5. (959 aa) |
| | DTL | Denticleless protein homolog; Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1, CDKN1A/p21(CIP1), KMT5A and SDE2. CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. [...] (720 aa) |
| | CAND1 | Cullin associated and neddylation dissociated 1. (1230 aa) |
| | LRRC41 | Leucine rich repeat containing 41. (791 aa) |
| | ASB5 | Ankyrin repeat and SOCS box containing 5. (329 aa) |
| | COPS4 | PCI domain-containing protein. (411 aa) |
| | RBX1 | RING-type domain-containing protein. (108 aa) |
| | CCDC93 | Coiled-coil domain-containing protein 93; May be involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery. Belongs to the CCDC93 family. (617 aa) |
| | COPS7A | PCI domain-containing protein. (275 aa) |
| | F1NU19_CHICK | WD_REPEATS_REGION domain-containing protein. (306 aa) |
| | RCAN1 | Uncharacterized protein. (194 aa) |
| | ASB11 | Ankyrin repeat and SOCS box containing 11. (322 aa) |
| | CUL4A | Cullin 4A; Belongs to the cullin family. (767 aa) |
| | LOC419074 | Uncharacterized protein. (765 aa) |
| | KLHDC2 | Uncharacterized protein. (407 aa) |
| | RNF7 | RING-type domain-containing protein. (114 aa) |
| | ARIH2 | RBR-type E3 ubiquitin transferase. (490 aa) |
| | COMMD8 | COMM domain-containing protein. (176 aa) |
| | SENP8 | ULP_PROTEASE domain-containing protein. (224 aa) |
| | VHL | Uncharacterized protein. (161 aa) |
| | TBL2 | Transducin beta like 2. (279 aa) |
| | COPS5 | MPN domain-containing protein. (337 aa) |
| | BTBD6 | BTB domain containing 6. (530 aa) |
| | SPSB4 | SplA/ryanodine receptor domain and SOCS box containing 4. (273 aa) |
| | FBXW11 | Uncharacterized protein. (531 aa) |
| | CUL5 | Cullin 5; Belongs to the cullin family. (662 aa) |
| | KLHL41 | Kelch like family member 41. (606 aa) |
| | CUL1 | Cullin 1; Belongs to the cullin family. (776 aa) |
| | COPS8 | PCI domain-containing protein. (230 aa) |
| | KLHL3 | Kelch like family member 3. (593 aa) |
| | CUL4B | Cullin 4B; Belongs to the cullin family. (883 aa) |
| | DCAF17 | DDB1 and CUL4 associated factor 17. (544 aa) |
| | COMMD9 | COMM domain containing 9. (199 aa) |
| | USP24 | Ubiquitin specific peptidase 24; Belongs to the peptidase C19 family. (2612 aa) |
| | DDB1 | DNA damage-binding protein 1; Required for DNA repair. Binds to DDB2 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair (By similarity). Also appears to function as a component of numerous distinct DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The functional specificity of the DCX E3 ubiquitin-protein li [...] (1139 aa) |
| | NDRG3 | NDRG family member 3. (387 aa) |
| | NAE1 | NEDD8-activating enzyme E1 regulatory subunit; Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M (By similarity). (535 aa) |
| | FBXW7 | Uncharacterized protein. (586 aa) |
| | CUL2 | CULLIN_2 domain-containing protein; Belongs to the cullin family. (774 aa) |
| | UBA3 | Ubiquitin like modifier activating enzyme 3. (442 aa) |
| | DCAF1 | DDB1 and CUL4 associated factor 1. (1505 aa) |
| | FBXO22 | FIST_C domain-containing protein. (393 aa) |
| | FBXO2 | F-box protein 2. (247 aa) |
| | GPALPP1 | Uncharacterized protein. (350 aa) |
| | TCEB1 | Skp1_POZ domain-containing protein; Belongs to the SKP1 family. (112 aa) |
| | FBXO4 | F-box protein 4. (354 aa) |
| | COMMD2 | COMM domain containing 2. (249 aa) |
| | NEDD8 | NEDD8 ubiquitin like modifier. (85 aa) |
| | PPP1R42 | Protein phosphatase 1 regulatory subunit 42. (320 aa) |
| | UBE2M | Ubiquitin conjugating enzyme E2 M; Belongs to the ubiquitin-conjugating enzyme family. (183 aa) |
| | KLHL20 | Kelch-like protein 20; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex involved in interferon response and anterograde Golgi to endosome transport. The BCR(KLHL20) E3 ubiquitin ligase complex mediates the ubiquitination of target proteins, leading to their degradation by the proteasome. It also specifically mediates 'Lys-33'-linked ubiquitination (By similarity). (613 aa) |
| | ENSGALP00000058556 | WD_REPEATS_REGION domain-containing protein. (410 aa) |
| | KLHDC1 | Kelch domain containing 1. (404 aa) |
| | COPS3 | COP9 signalosome complex subunit 3; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of E3 ligase complexes, leading to modify the Ubl ligase activity (By similarity). (423 aa) |
| | UBE2F | NEDD8-conjugating enzyme UBE2F; Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5; Belongs to the ubiquitin-conjugating enzyme family. UBE2F subfamily. (272 aa) |
| | LRR1 | Leucine rich repeat protein 1. (449 aa) |
| | TRIM63 | Tripartite motif containing 63. (509 aa) |
| | DCAF11 | Uncharacterized protein. (92 aa) |
| | SPSB1 | SplA/ryanodine receptor domain and SOCS box containing 1. (273 aa) |
| | FBXO31 | F-box protein 31. (573 aa) |
| | DCAF6 | WD_REPEATS_REGION domain-containing protein. (486 aa) |
| | COMMD6 | COMM domain containing 6. (207 aa) |
| | DDA1 | DET1- and DDB1-associated protein 1; May be involved in ubiquitination and subsequent proteasomal degradation of target proteins. Component of the DDD-E2 complexes which may provide a platform for interaction with CUL4A and WD repeat proteins (By similarity); Belongs to the DDA1 family. (166 aa) |
| | ENSGALP00000072290 | WD_REPEATS_REGION domain-containing protein. (89 aa) |
| | WDTC1 | WD and tetratricopeptide repeats 1. (697 aa) |
| | COP1 | COP1 E3 ubiquitin ligase. (723 aa) |
| | ENSGALP00000073564 | Uncharacterized protein. (243 aa) |
| | ENSGALP00000073605 | Uncharacterized protein. (253 aa) |
| | ZNF385D | Uncharacterized protein. (512 aa) |
| | DCAF8 | Uncharacterized protein. (444 aa) |
| | GPATCH8 | G-patch domain containing 8. (1660 aa) |
| | DCUN1D2 | DCN1-like protein. (259 aa) |
