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CISH | Cytokine-inducible SH2-containing protein; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. CIS is involved in the negative regulation of cytokines that signal through the JAK-STAT5 pathway such as erythropoietin, prolactin and interleukin 3 (IL3) receptor. Inhibits STAT5 trans-activation by suppressing its tyrosine phosphorylation. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasom [...] (258 aa) | ||||
WSB1 | SOCS box-containing WD protein SWiP-1. (421 aa) | ||||
RNF7 | RING-type domain-containing protein. (114 aa) | ||||
ARIH2 | RBR-type E3 ubiquitin transferase. (490 aa) | ||||
CUL5 | Cullin 5; Belongs to the cullin family. (662 aa) |