(7 nodes) Cleavage of the damaged pyrimidine network (Gallus gallus)

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Your Input:
	NEIL1	FPG_CAT domain-containing protein. (382 aa)
	NTHL1	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (281 aa)
	NEIL2	FPG_CAT domain-containing protein. (328 aa)
	MBD4	Uncharacterized protein. (438 aa)
	UNG	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (299 aa)
	TDG	UDG domain-containing protein. (546 aa)
	SMUG1	Single-strand-selective monofunctional uracil-DNA glycosylase 1. (332 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MBD4	NEIL1	ENSGALP00000032601	ENSGALP00000002406	Uncharacterized protein.	FPG_CAT domain-containing protein.	0.574
MBD4	SMUG1	ENSGALP00000032601	ENSGALP00000071202	Uncharacterized protein.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.885
MBD4	TDG	ENSGALP00000032601	ENSGALP00000045187	Uncharacterized protein.	UDG domain-containing protein.	0.886
NEIL1	MBD4	ENSGALP00000002406	ENSGALP00000032601	FPG_CAT domain-containing protein.	Uncharacterized protein.	0.574
NEIL1	NEIL2	ENSGALP00000002406	ENSGALP00000026842	FPG_CAT domain-containing protein.	FPG_CAT domain-containing protein.	0.953
NEIL1	NTHL1	ENSGALP00000002406	ENSGALP00000008999	FPG_CAT domain-containing protein.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.810
NEIL1	SMUG1	ENSGALP00000002406	ENSGALP00000071202	FPG_CAT domain-containing protein.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.779
NEIL1	TDG	ENSGALP00000002406	ENSGALP00000045187	FPG_CAT domain-containing protein.	UDG domain-containing protein.	0.638
NEIL1	UNG	ENSGALP00000002406	ENSGALP00000033675	FPG_CAT domain-containing protein.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.631
NEIL2	NEIL1	ENSGALP00000026842	ENSGALP00000002406	FPG_CAT domain-containing protein.	FPG_CAT domain-containing protein.	0.953
NEIL2	NTHL1	ENSGALP00000026842	ENSGALP00000008999	FPG_CAT domain-containing protein.	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	0.892
NEIL2	SMUG1	ENSGALP00000026842	ENSGALP00000071202	FPG_CAT domain-containing protein.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.639
NEIL2	TDG	ENSGALP00000026842	ENSGALP00000045187	FPG_CAT domain-containing protein.	UDG domain-containing protein.	0.626
NEIL2	UNG	ENSGALP00000026842	ENSGALP00000033675	FPG_CAT domain-containing protein.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.541
NTHL1	NEIL1	ENSGALP00000008999	ENSGALP00000002406	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	FPG_CAT domain-containing protein.	0.810
NTHL1	NEIL2	ENSGALP00000008999	ENSGALP00000026842	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	FPG_CAT domain-containing protein.	0.892
NTHL1	SMUG1	ENSGALP00000008999	ENSGALP00000071202	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	0.451
NTHL1	TDG	ENSGALP00000008999	ENSGALP00000045187	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	UDG domain-containing protein.	0.785
NTHL1	UNG	ENSGALP00000008999	ENSGALP00000033675	Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family.	Uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.	0.851
SMUG1	MBD4	ENSGALP00000071202	ENSGALP00000032601	Single-strand-selective monofunctional uracil-DNA glycosylase 1.	Uncharacterized protein.	0.885