(15 nodes) Caspase activation via Death Receptors in the presence of ligand network (Gallus gallus)

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

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Your Input:
	FASLG	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (295 aa)
	TRADD	TNFRSF1A associated via death domain. (461 aa)
	LOC378902	Uncharacterized protein. (416 aa)
	TLR4	Toll-like receptor 4; Belongs to the Toll-like receptor family. (843 aa)
	FADD	Fas associated via death domain. (195 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
	RIPK1	Uncharacterized protein. (682 aa)
	FAS	Uncharacterized protein. (339 aa)
	TICAM1	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines. (735 aa)
	CD14	Uncharacterized protein. (465 aa)
	TNFSF10	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family. (292 aa)
	LY96	Lymphocyte antigen 96. (155 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
	TNFRSF10B	Uncharacterized protein. (429 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CASP3	CASP8	ENSGALP00000068843	ENSGALP00000013591	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.968
CASP3	FADD	ENSGALP00000068843	ENSGALP00000012326	Caspase-3; Belongs to the peptidase C14A family.	Fas associated via death domain.	0.910
CASP3	FAS	ENSGALP00000068843	ENSGALP00000039128	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.764
CASP3	FASLG	ENSGALP00000068843	ENSGALP00000004854	Caspase-3; Belongs to the peptidase C14A family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.772
CASP3	LOC378902	ENSGALP00000068843	ENSGALP00000010331	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.586
CASP3	RIPK1	ENSGALP00000068843	ENSGALP00000036418	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.887
CASP3	TLR4	ENSGALP00000068843	ENSGALP00000011319	Caspase-3; Belongs to the peptidase C14A family.	Toll-like receptor 4; Belongs to the Toll-like receptor family.	0.749
CASP3	TNFRSF10B	ENSGALP00000068843	ENSGALP00000071222	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.653
CASP3	TNFSF10	ENSGALP00000068843	ENSGALP00000061754	Caspase-3; Belongs to the peptidase C14A family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.692
CASP3	TRADD	ENSGALP00000068843	ENSGALP00000005055	Caspase-3; Belongs to the peptidase C14A family.	TNFRSF1A associated via death domain.	0.821
CASP3	TRAF2	ENSGALP00000068843	ENSGALP00000070161	Caspase-3; Belongs to the peptidase C14A family.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.716
CASP8	CASP3	ENSGALP00000013591	ENSGALP00000068843	Uncharacterized protein; Belongs to the peptidase C14A family.	Caspase-3; Belongs to the peptidase C14A family.	0.968
CASP8	CD14	ENSGALP00000013591	ENSGALP00000052840	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.516
CASP8	FADD	ENSGALP00000013591	ENSGALP00000012326	Uncharacterized protein; Belongs to the peptidase C14A family.	Fas associated via death domain.	0.999
CASP8	FAS	ENSGALP00000013591	ENSGALP00000039128	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.887
CASP8	FASLG	ENSGALP00000013591	ENSGALP00000004854	Uncharacterized protein; Belongs to the peptidase C14A family.	TNF_2 domain-containing protein; Belongs to the tumor necrosis factor family.	0.818
CASP8	LOC378902	ENSGALP00000013591	ENSGALP00000010331	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.621
CASP8	LY96	ENSGALP00000013591	ENSGALP00000066705	Uncharacterized protein; Belongs to the peptidase C14A family.	Lymphocyte antigen 96.	0.510
CASP8	RIPK1	ENSGALP00000013591	ENSGALP00000036418	Uncharacterized protein; Belongs to the peptidase C14A family.	Uncharacterized protein.	0.993
CASP8	TICAM1	ENSGALP00000013591	ENSGALP00000041887	Uncharacterized protein; Belongs to the peptidase C14A family.	TIR domain-containing adapter molecule 1; Involved in innate immunity against invading pathogens. Component of a multi-helicase-TICAM1 complex that acts as a cytoplasmic sensor of viral double-stranded RNA (dsRNA) and plays a role in the activation of a cascade of antiviral responses including the induction of proinflammatory cytokines.	0.682