(8 nodes) Prolonged ERK activation events network (Gallus gallus)

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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Your Input:
	MAPK3	Mitogen-activated protein kinase. (421 aa)
	CRK	Adapter molecule crk; May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity). (305 aa)
	FRS2	IRS-type PTB domain-containing protein. (508 aa)
	BRAF	Serine/threonine-protein kinase B-raf; Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. (806 aa)
	YWHAB	14-3-3 protein beta/alpha; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity); Belongs to the 14-3-3 family. (244 aa)
	MAP2K1	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (395 aa)
	KIDINS220	Kinase D interacting substrate 220. (1810 aa)
	RAPGEF1	Rap guanine nucleotide exchange factor 1. (1225 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAF	MAP2K1	ENSGALP00000020950	ENSGALP00000050365	Serine/threonine-protein kinase B-raf; Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.982
BRAF	MAPK3	ENSGALP00000020950	ENSGALP00000002278	Serine/threonine-protein kinase B-raf; Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.	Mitogen-activated protein kinase.	0.817
BRAF	YWHAB	ENSGALP00000020950	ENSGALP00000043305	Serine/threonine-protein kinase B-raf; Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.	14-3-3 protein beta/alpha; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity); Belongs to the 14-3-3 family.	0.968
CRK	FRS2	ENSGALP00000004174	ENSGALP00000016181	Adapter molecule crk; May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity).	IRS-type PTB domain-containing protein.	0.792
CRK	KIDINS220	ENSGALP00000004174	ENSGALP00000067787	Adapter molecule crk; May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity).	Kinase D interacting substrate 220.	0.924
CRK	RAPGEF1	ENSGALP00000004174	ENSGALP00000069871	Adapter molecule crk; May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity).	Rap guanine nucleotide exchange factor 1.	0.952
FRS2	CRK	ENSGALP00000016181	ENSGALP00000004174	IRS-type PTB domain-containing protein.	Adapter molecule crk; May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity).	0.792
FRS2	KIDINS220	ENSGALP00000016181	ENSGALP00000067787	IRS-type PTB domain-containing protein.	Kinase D interacting substrate 220.	0.459
FRS2	MAPK3	ENSGALP00000016181	ENSGALP00000002278	IRS-type PTB domain-containing protein.	Mitogen-activated protein kinase.	0.469
FRS2	RAPGEF1	ENSGALP00000016181	ENSGALP00000069871	IRS-type PTB domain-containing protein.	Rap guanine nucleotide exchange factor 1.	0.680
KIDINS220	CRK	ENSGALP00000067787	ENSGALP00000004174	Kinase D interacting substrate 220.	Adapter molecule crk; May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity).	0.924
KIDINS220	FRS2	ENSGALP00000067787	ENSGALP00000016181	Kinase D interacting substrate 220.	IRS-type PTB domain-containing protein.	0.459
MAP2K1	BRAF	ENSGALP00000050365	ENSGALP00000020950	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase B-raf; Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.	0.982
MAP2K1	MAPK3	ENSGALP00000050365	ENSGALP00000002278	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Mitogen-activated protein kinase.	0.967
MAP2K1	YWHAB	ENSGALP00000050365	ENSGALP00000043305	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	14-3-3 protein beta/alpha; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity); Belongs to the 14-3-3 family.	0.698
MAPK3	BRAF	ENSGALP00000002278	ENSGALP00000020950	Mitogen-activated protein kinase.	Serine/threonine-protein kinase B-raf; Protein kinase involved in the activation of the MAP signaling cascade. May play a role in transducing specific signals in neural cells; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily.	0.817
MAPK3	FRS2	ENSGALP00000002278	ENSGALP00000016181	Mitogen-activated protein kinase.	IRS-type PTB domain-containing protein.	0.469
MAPK3	MAP2K1	ENSGALP00000002278	ENSGALP00000050365	Mitogen-activated protein kinase.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.967
MAPK3	YWHAB	ENSGALP00000002278	ENSGALP00000043305	Mitogen-activated protein kinase.	14-3-3 protein beta/alpha; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity); Belongs to the 14-3-3 family.	0.580
RAPGEF1	CRK	ENSGALP00000069871	ENSGALP00000004174	Rap guanine nucleotide exchange factor 1.	Adapter molecule crk; May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity).	0.952