STRINGSTRING
CRK CRK STAT3 STAT3 STAT5A STAT5A PIK3R2 PIK3R2 PLCG1 PLCG1 SRC SRC PTPN11 PTPN11 PIK3CB PIK3CB PIK3CA PIK3CA PDGFB PDGFB RASA1 RASA1 NRAS NRAS PDGFRB PDGFRB STAT1 STAT1 BCAR1 BCAR1 SOS1 SOS1 KRAS KRAS PDGFA PDGFA ENSGALP00000065128 ENSGALP00000065128 NCK1 NCK1 PIK3R1 PIK3R1 RAPGEF1 RAPGEF1 ENSGALP00000071809 ENSGALP00000071809 HRAS HRAS
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CRKAdapter molecule crk; May mediate attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. May regulate the EFNA5-EPHA3 signaling (By similarity). (305 aa)
STAT3Signal transducer and activator of transcription 3; Transcription factor that binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute-phase protein genes. (771 aa)
STAT5ASignal transducer and activator of transcription. (764 aa)
PIK3R2Uncharacterized protein. (731 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1277 aa)
SRCProto-oncogene tyrosine-protein kinase Src; Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Due to functional redundancy bet [...] (539 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type 11; This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates (By similarity). May play a positive role during the stages of erythroid cell proliferation. (593 aa)
PIK3CBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1066 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
PDGFBPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (251 aa)
RASA1Uncharacterized protein. (1120 aa)
NRASGTPase NRas; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
PDGFRBPlatelet derived growth factor receptor beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1073 aa)
STAT1Signal transducer and activator of transcription. (755 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (905 aa)
SOS1SOS Ras/Rac guanine nucleotide exchange factor 1. (1319 aa)
KRASUncharacterized protein. (189 aa)
PDGFAPlatelet-derived growth factor A chain long form; Belongs to the PDGF/VEGF growth factor family. (211 aa)
ENSGALP00000065128SH2 domain-containing protein. (126 aa)
NCK1Cytoplasmic protein. (380 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1225 aa)
ENSGALP00000071809SH2 domain-containing protein. (217 aa)
HRASGTPase HRas, N-terminally processed; Ras proteins bind GDP/GTP and possess intrinsic GTPase activity; Belongs to the small GTPase superfamily. Ras family. (189 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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