STRINGSTRING
PPP2CA PPP2CA SKP1 SKP1 TLE3 TLE3 TCF7L2 TCF7L2 PPP2R5A PPP2R5A PPP2CB PPP2CB PPP2R5E PPP2R5E RBX1 RBX1 TLE4 TLE4 AMER1 AMER1 CTNNB1 CTNNB1 CUL1 CUL1 TLE1 TLE1 RPS27A RPS27A APC APC TLE2 TLE2 ZRANB1 ZRANB1 LOC101747587 LOC101747587 PPP2R5D PPP2R5D CSNK1A1 CSNK1A1 CTBP2 CTBP2 CTBP1 CTBP1 TCF7 TCF7 GSK3B GSK3B TCF7L1 TCF7L1 PPP2R5C PPP2R5C ENSGALP00000071317 ENSGALP00000071317 LEF1 LEF1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PPP2CASerine/threonine-protein phosphatase. (309 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
TLE3TLE family member 3, transcriptional corepressor. (779 aa)
TCF7L2HMG box domain-containing protein. (598 aa)
PPP2R5ASerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (476 aa)
PPP2CBSerine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase; Belongs to the PPP phosphatase family. PP-1 subfamily. (309 aa)
PPP2R5ESerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (467 aa)
RBX1RING-type domain-containing protein. (108 aa)
TLE4Uncharacterized protein. (773 aa)
AMER1APC membrane recruitment protein 1. (1163 aa)
CTNNB1Uncharacterized protein. (781 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
TLE1TLE family member 1, transcriptional corepressor. (780 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
APCAPC regulator of WNT signaling pathway. (2853 aa)
TLE2Uncharacterized protein. (353 aa)
ZRANB1Zinc finger RANBP2-type containing 1. (708 aa)
LOC101747587Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
PPP2R5DSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (543 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly. (370 aa)
CTBP2C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (442 aa)
CTBP1Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (447 aa)
TCF7HMG box domain-containing protein. (397 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
TCF7L1Transcription factor 7 like 1. (552 aa)
PPP2R5CSerine/threonine protein phosphatase 2A regulatory subunit; Belongs to the phosphatase 2A regulatory subunit. (580 aa)
ENSGALP00000071317Uncharacterized protein. (364 aa)
LEF1HMG box domain-containing protein. (412 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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