(12 nodes) Metabolism of Angiotensinogen to Angiotensins network (Gallus gallus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	REN	Renin; Belongs to the peptidase A1 family. (423 aa)
	CTSD	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL. (398 aa)
	MME	Neprilysin. (750 aa)
	AGT	Angiotensinogen; Belongs to the serpin family. (464 aa)
	ACE2	Angiotensin-converting enzyme. (808 aa)
	ATP6AP2	Uncharacterized protein. (354 aa)
	ENPEP	Aminopeptidase. (943 aa)
	CTSZ	Cathepsin Z; Belongs to the peptidase C1 family. (325 aa)
	LOC769704	Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (557 aa)
	AOPEP	Aminopeptidase O (putative). (826 aa)
	CTSG	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
	LOC100858579	Peptidase S1 domain-containing protein. (243 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACE2	AGT	ENSGALP00000026662	ENSGALP00000018089	Angiotensin-converting enzyme.	Angiotensinogen; Belongs to the serpin family.	0.969
ACE2	ATP6AP2	ENSGALP00000026662	ENSGALP00000035865	Angiotensin-converting enzyme.	Uncharacterized protein.	0.511
ACE2	ENPEP	ENSGALP00000026662	ENSGALP00000049914	Angiotensin-converting enzyme.	Aminopeptidase.	0.746
ACE2	MME	ENSGALP00000026662	ENSGALP00000016796	Angiotensin-converting enzyme.	Neprilysin.	0.663
ACE2	REN	ENSGALP00000026662	ENSGALP00000000756	Angiotensin-converting enzyme.	Renin; Belongs to the peptidase A1 family.	0.981
AGT	ACE2	ENSGALP00000018089	ENSGALP00000026662	Angiotensinogen; Belongs to the serpin family.	Angiotensin-converting enzyme.	0.969
AGT	AOPEP	ENSGALP00000018089	ENSGALP00000057157	Angiotensinogen; Belongs to the serpin family.	Aminopeptidase O (putative).	0.787
AGT	ATP6AP2	ENSGALP00000018089	ENSGALP00000035865	Angiotensinogen; Belongs to the serpin family.	Uncharacterized protein.	0.903
AGT	CTSD	ENSGALP00000018089	ENSGALP00000010662	Angiotensinogen; Belongs to the serpin family.	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL.	0.863
AGT	CTSG	ENSGALP00000018089	ENSGALP00000062526	Angiotensinogen; Belongs to the serpin family.	Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family.	0.859
AGT	CTSZ	ENSGALP00000018089	ENSGALP00000051470	Angiotensinogen; Belongs to the serpin family.	Cathepsin Z; Belongs to the peptidase C1 family.	0.800
AGT	ENPEP	ENSGALP00000018089	ENSGALP00000049914	Angiotensinogen; Belongs to the serpin family.	Aminopeptidase.	0.831
AGT	LOC100858579	ENSGALP00000018089	ENSGALP00000073675	Angiotensinogen; Belongs to the serpin family.	Peptidase S1 domain-containing protein.	0.762
AGT	MME	ENSGALP00000018089	ENSGALP00000016796	Angiotensinogen; Belongs to the serpin family.	Neprilysin.	0.855
AGT	REN	ENSGALP00000018089	ENSGALP00000000756	Angiotensinogen; Belongs to the serpin family.	Renin; Belongs to the peptidase A1 family.	0.975
AOPEP	AGT	ENSGALP00000057157	ENSGALP00000018089	Aminopeptidase O (putative).	Angiotensinogen; Belongs to the serpin family.	0.787
AOPEP	ENPEP	ENSGALP00000057157	ENSGALP00000049914	Aminopeptidase O (putative).	Aminopeptidase.	0.585
ATP6AP2	ACE2	ENSGALP00000035865	ENSGALP00000026662	Uncharacterized protein.	Angiotensin-converting enzyme.	0.511
ATP6AP2	AGT	ENSGALP00000035865	ENSGALP00000018089	Uncharacterized protein.	Angiotensinogen; Belongs to the serpin family.	0.903
ATP6AP2	CTSD	ENSGALP00000035865	ENSGALP00000010662	Uncharacterized protein.	Cathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL.	0.749