(17 nodes) FCERI mediated NF-kB activation network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

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protein homology

Your Input:
	CARD11	Uncharacterized protein. (1170 aa)
	SKP1	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
	TAB1	PPM-type phosphatase domain-containing protein. (502 aa)
	TAB2	TGF-beta activated kinase 1 (MAP3K7) binding protein 2. (697 aa)
	TAB3	TGF-beta activated kinase 1 (MAP3K7) binding protein 3. (679 aa)
	UBE2D1	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	NFKB1	Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA. (983 aa)
	CDC34	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family. (235 aa)
	BCL10	CARD domain-containing protein. (244 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7. (643 aa)
	FBXW11	Uncharacterized protein. (531 aa)
	MALT1	MALT1 paracaspase. (816 aa)
	CUL1	Cullin 1; Belongs to the cullin family. (776 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
	LOC101747587	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
	UBE2D2	Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (545 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BCL10	CARD11	ENSGALP00000041735	ENSGALP00000007002	CARD domain-containing protein.	Uncharacterized protein.	0.744
BCL10	MALT1	ENSGALP00000041735	ENSGALP00000046622	CARD domain-containing protein.	MALT1 paracaspase.	0.900
BCL10	MAP3K7	ENSGALP00000041735	ENSGALP00000043939	CARD domain-containing protein.	Mitogen-activated protein kinase kinase kinase 7.	0.501
BCL10	TAB2	ENSGALP00000041735	ENSGALP00000020155	CARD domain-containing protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.499
BCL10	TRAF6	ENSGALP00000041735	ENSGALP00000068399	CARD domain-containing protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.506
CARD11	BCL10	ENSGALP00000007002	ENSGALP00000041735	Uncharacterized protein.	CARD domain-containing protein.	0.744
CARD11	MALT1	ENSGALP00000007002	ENSGALP00000046622	Uncharacterized protein.	MALT1 paracaspase.	0.989
CARD11	MAP3K7	ENSGALP00000007002	ENSGALP00000043939	Uncharacterized protein.	Mitogen-activated protein kinase kinase kinase 7.	0.811
CARD11	TAB2	ENSGALP00000007002	ENSGALP00000020155	Uncharacterized protein.	TGF-beta activated kinase 1 (MAP3K7) binding protein 2.	0.691
CARD11	TRAF6	ENSGALP00000007002	ENSGALP00000068399	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.842
CDC34	CUL1	ENSGALP00000040341	ENSGALP00000046909	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Cullin 1; Belongs to the cullin family.	0.840
CDC34	FBXW11	ENSGALP00000040341	ENSGALP00000045042	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Uncharacterized protein.	0.640
CDC34	LOC101747587	ENSGALP00000040341	ENSGALP00000053353	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...]	0.822
CDC34	NFKB1	ENSGALP00000040341	ENSGALP00000036814	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Nuclear factor NF-kappa-B p105 subunit; P105 is the precursor of the p50 subunit of the nuclear factor NF-kappa-B, which binds to the kappa-B consensus sequence 5'- GGRNNYYCC-3', located in the enhancer region of genes involved in immune response and acute phase reactions. The precursor protein itself does not bind to DNA.	0.430
CDC34	RPS27A	ENSGALP00000040341	ENSGALP00000050085	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]	0.839
CDC34	SKP1	ENSGALP00000040341	ENSGALP00000010447	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity).	0.855
CDC34	UBE2D1	ENSGALP00000040341	ENSGALP00000033525	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family.	0.552
CDC34	UBE2D2	ENSGALP00000040341	ENSGALP00000053702	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family.	0.564
CUL1	CDC34	ENSGALP00000046909	ENSGALP00000040341	Cullin 1; Belongs to the cullin family.	Cell division cycle 34; Belongs to the ubiquitin-conjugating enzyme family.	0.840
CUL1	FBXW11	ENSGALP00000046909	ENSGALP00000045042	Cullin 1; Belongs to the cullin family.	Uncharacterized protein.	0.994