STRINGSTRING
GH GH REN REN SPCS1 SPCS1 TSHB-2 TSHB-2 GPR119 GPR119 GNG13 GNG13 INS INS CTSD CTSD GHRL GHRL GNAT3 GNAT3 MME MME SPCS3 SPCS3 AGT AGT MBOAT4 MBOAT4 EXOC5 EXOC5 FSHB FSHB IGF1 IGF1 EXOC2 EXOC2 EXOC3 EXOC3 PCSK1 PCSK1 ACE2 ACE2 GCG GCG ATP6AP2 ATP6AP2 GNB1 GNB1 FFAR4 FFAR4 SLC30A8 SLC30A8 EXOC1 EXOC1 ERO1B ERO1B EXOC6 EXOC6 GNB3 GNB3 SEC11A SEC11A ENPEP ENPEP CTSZ CTSZ DPP4 DPP4 LOC769704 LOC769704 EXOC7 EXOC7 SEC11C SEC11C AOPEP AOPEP SLC30A5 SLC30A5 CTSG CTSG POMC POMC INHBE INHBE GIP GIP BCHE BCHE LOC415787 LOC415787 INHBC INHBC CGA CGA EXOC4 EXOC4 LOC100858579 LOC100858579
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GHSomatotropin; Growth hormone plays an important role in growth control. (216 aa)
RENRenin; Belongs to the peptidase A1 family. (423 aa)
SPCS1Uncharacterized protein. (166 aa)
TSHB-2Thyrotropin subunit beta; Indispensable for the control of thyroid structure and metabolism. (134 aa)
GPR119G protein-coupled receptor 119. (320 aa)
GNG13G protein gamma domain-containing protein. (67 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (107 aa)
CTSDCathepsin D heavy chain; Acid protease active in intracellular protein breakdown. In chicken it is a key enzyme for yolk formation as it is capable of catalyzing intra oocytic break down of protein components of both vitellogenin and VLDL. (398 aa)
GHRLPreproghrelin. (116 aa)
GNAT3Uncharacterized protein. (354 aa)
MMENeprilysin. (750 aa)
SPCS3Signal peptidase complex subunit 3; Component of the microsomal signal peptidase complex which removes signal peptides and other N-terminal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. (180 aa)
AGTAngiotensinogen; Belongs to the serpin family. (464 aa)
MBOAT4Uncharacterized protein; Belongs to the membrane-bound acyltransferase family. (424 aa)
EXOC5Uncharacterized protein. (867 aa)
FSHBFollicle stimulating hormone, beta polypeptide. (131 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins. Its binding to integrins and subsequent ternary complex fo [...] (153 aa)
EXOC2Exocyst complex component 2; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Belongs to the SEC5 family. (925 aa)
EXOC3Uncharacterized protein. (745 aa)
PCSK1Proprotein convertase subtilisin/kexin type 1; Belongs to the peptidase S8 family. (748 aa)
ACE2Angiotensin-converting enzyme. (808 aa)
GCGGlicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
ATP6AP2Uncharacterized protein. (354 aa)
GNB1WD_REPEATS_REGION domain-containing protein. (340 aa)
FFAR4Free fatty acid receptor 4. (349 aa)
SLC30A8Solute carrier family 30 member 8. (384 aa)
EXOC1Exocyst complex component 1. (920 aa)
ERO1BEndoplasmic reticulum oxidoreductase 1 beta. (444 aa)
EXOC6Exocyst complex component; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (808 aa)
GNB3G protein subunit beta 3. (340 aa)
SEC11ASignal peptidase complex catalytic subunit SEC11. (179 aa)
ENPEPAminopeptidase. (943 aa)
CTSZCathepsin Z; Belongs to the peptidase C1 family. (325 aa)
DPP4Uncharacterized protein; Belongs to the peptidase S9B family. (760 aa)
LOC769704Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (557 aa)
EXOC7Exocyst complex component 7; Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. (787 aa)
SEC11CSignal peptidase complex catalytic subunit SEC11. (177 aa)
AOPEPAminopeptidase O (putative). (826 aa)
SLC30A5Zinc transporter 5; Functions as a zinc transporter. Partly regulates cellular zinc homeostasis. Required with ZNT7 for activation of zinc-requiring enzymes, alkaline phosphatases (ALPs). Transports zinc into the lumens of the Golgi apparatus and the vesicular compartments where ALPs locate, thus, converting apoALPs to holoALPs. Required with ZNT6 and ZNT7 for the activation of TNAP (By similarity); Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily. (770 aa)
CTSGPeptidase S1 domain-containing protein; Belongs to the peptidase S1 family. (246 aa)
POMCUncharacterized protein. (251 aa)
INHBETGF_BETA_2 domain-containing protein. (349 aa)
GIPGLUCAGON domain-containing protein. (139 aa)
BCHECarboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (603 aa)
LOC415787Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. (461 aa)
INHBCInhibin subunit beta C. (351 aa)
CGAGlycoprotein hormones alpha chain; Belongs to the glycoprotein hormones subunit alpha family. (120 aa)
EXOC4Sec8_exocyst domain-containing protein. (1018 aa)
LOC100858579Peptidase S1 domain-containing protein. (243 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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