25 items (Gallus gallus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	RAMP1	Receptor activity modifying protein 1. (125 aa)
	GHRH	GHRH/PACAP-like. (172 aa)
	GHRHR	G protein-coupled pituitary GHRH receptor; Belongs to the G-protein coupled receptor 2 family. (419 aa)
	VIPR1	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (446 aa)
	PTH2R	Parathyroid hormone-related protein type-1 receptor; Belongs to the G-protein coupled receptor 2 family. (538 aa)
	VIPR2	VPAC2 receptor; Belongs to the G-protein coupled receptor 2 family. (439 aa)
	CALCR	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family. (469 aa)
	IAPP	Amyloid protein. (135 aa)
	VIP	Intestinal peptide PHI-27-like; VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder; Belongs to the glucagon family. (200 aa)
	CRHBP	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (345 aa)
	GCG	Glicentin-related polypeptide; Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. GLP-2 stimulates intestinal growth and up-regulates villus height in the small intestine, concomitant with increased crypt cell proliferation and decreased enterocyte apoptosis. (206 aa)
	RAMP2	Receptor activity modifying protein 2. (176 aa)
	PTH	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. (119 aa)
	RAMP3	Receptor activity modifying protein 3. (156 aa)
	CRH	Corticotropin releasing hormone. (167 aa)
	UCN3	Urocortin 3. (154 aa)
	GLP2R	Glucagon-like peptide 2 receptor; Belongs to the G-protein coupled receptor 2 family. (529 aa)
	GIP	GLUCAGON domain-containing protein. (139 aa)
	GCGR	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (532 aa)
	CALCRL	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family. (457 aa)
	CRHR2	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (427 aa)
	PTHLH	Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family. (214 aa)
	ADCYAP1R1	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (499 aa)
	UCN	Urocortin. (100 aa)
	GIPR	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. (428 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ADCYAP1R1	GHRH	ENSGALP00000071057	ENSGALP00000006088	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	GHRH/PACAP-like.	0.568
ADCYAP1R1	UCN	ENSGALP00000071057	ENSGALP00000071657	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	Urocortin.	0.487
ADCYAP1R1	VIPR2	ENSGALP00000071057	ENSGALP00000010609	Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family.	VPAC2 receptor; Belongs to the G-protein coupled receptor 2 family.	0.425
CALCR	CALCRL	ENSGALP00000015462	ENSGALP00000068054	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family.	0.903
CALCR	GHRH	ENSGALP00000015462	ENSGALP00000006088	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	GHRH/PACAP-like.	0.437
CALCR	IAPP	ENSGALP00000015462	ENSGALP00000021476	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Amyloid protein.	0.937
CALCR	PTH	ENSGALP00000015462	ENSGALP00000044567	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.733
CALCR	PTHLH	ENSGALP00000015462	ENSGALP00000069044	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Parathyroid hormone-related protein; Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport; Belongs to the parathyroid hormone family.	0.406
CALCR	RAMP1	ENSGALP00000015462	ENSGALP00000006047	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Receptor activity modifying protein 1.	0.995
CALCR	RAMP2	ENSGALP00000015462	ENSGALP00000040567	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Receptor activity modifying protein 2.	0.959
CALCR	RAMP3	ENSGALP00000015462	ENSGALP00000050055	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Receptor activity modifying protein 3.	0.994
CALCR	UCN	ENSGALP00000015462	ENSGALP00000071657	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	Urocortin.	0.449
CALCRL	CALCR	ENSGALP00000068054	ENSGALP00000015462	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family.	Calcitonin receptor; Belongs to the G-protein coupled receptor 2 family.	0.903
CALCRL	IAPP	ENSGALP00000068054	ENSGALP00000021476	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family.	Amyloid protein.	0.925
CALCRL	PTH	ENSGALP00000068054	ENSGALP00000044567	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family.	Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family.	0.464
CALCRL	RAMP1	ENSGALP00000068054	ENSGALP00000006047	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family.	Receptor activity modifying protein 1.	0.999
CALCRL	RAMP2	ENSGALP00000068054	ENSGALP00000040567	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family.	Receptor activity modifying protein 2.	0.988
CALCRL	RAMP3	ENSGALP00000068054	ENSGALP00000050055	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family.	Receptor activity modifying protein 3.	0.998
CALCRL	UCN	ENSGALP00000068054	ENSGALP00000071657	Calcitonin receptor-like receptor; Belongs to the G-protein coupled receptor 2 family.	Urocortin.	0.623
CRH	CRHBP	ENSGALP00000050250	ENSGALP00000024136	Corticotropin releasing hormone.	Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family.	0.978