(25 nodes) Regulation of TNFR1 signaling network (Gallus gallus)

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Predicted Interactions

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Your Input:
	MAPKAPK2	MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (395 aa)
	TRAF1	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	TRADD	TNFRSF1A associated via death domain. (461 aa)
	USP4	Ubiquitin carboxyl-terminal hydrolase. (963 aa)
	FADD	Fas associated via death domain. (195 aa)
	SPATA2	Uncharacterized protein. (523 aa)
	CASP8	Uncharacterized protein; Belongs to the peptidase C14A family. (482 aa)
	TBK1	Protein kinase domain-containing protein. (729 aa)
	CYLD	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family. (941 aa)
	OTUD7B	OTU deubiquitinase 7B. (843 aa)
	IKBKE	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (837 aa)
	UBE2D1	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	RIPK1	Uncharacterized protein. (682 aa)
	TNFAIP3	TNF alpha induced protein 3. (806 aa)
	RPS27A	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
	UBE2D3	UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (147 aa)
	TAX1BP1	Uncharacterized protein. (816 aa)
	ULK1	Unc-51 like autophagy activating kinase 1. (1081 aa)
	LOC101747587	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
	UBE2D2	Ubiquitin conjugating enzyme E2 D2; Belongs to the ubiquitin-conjugating enzyme family. (238 aa)
	STUB1	STIP1 homology and U box-containing protein 1; E3 ubiquitin-protein ligase which targets misfolded chaperone substrates towards proteasomal degradation. Ubiquitinates NOS1 in concert with Hsp70 and Hsp40. Mediates polyubiquitination of DNA polymerase beta (POLB), thereby playing a role in base-excision repair: catalyzes polyubiquitination by amplifying the HUWE1/ARF-BP1-dependent monoubiquitination and leading to POLB-degradation by the proteasome. Mediates polyubiquitination of CYP3A4. May ubiquitinate EPHA2 and regulate the receptor stability and activity through proteasomal degradation. (314 aa)
	LOC107051192	RanBP2-type domain-containing protein. (1255 aa)
	CASP3	Caspase-3; Belongs to the peptidase C14A family. (283 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (544 aa)
	BIRC8	Inhibitor of apoptosis protein 3. (493 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BIRC8	CASP3	ENSGALP00000073811	ENSGALP00000068843	Inhibitor of apoptosis protein 3.	Caspase-3; Belongs to the peptidase C14A family.	0.999
BIRC8	CASP8	ENSGALP00000073811	ENSGALP00000013591	Inhibitor of apoptosis protein 3.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.830
BIRC8	CYLD	ENSGALP00000073811	ENSGALP00000016104	Inhibitor of apoptosis protein 3.	CYLD lysine 63 deubiquitinase; Belongs to the peptidase C19 family.	0.617
BIRC8	FADD	ENSGALP00000073811	ENSGALP00000012326	Inhibitor of apoptosis protein 3.	Fas associated via death domain.	0.648
BIRC8	IKBKE	ENSGALP00000073811	ENSGALP00000021757	Inhibitor of apoptosis protein 3.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.652
BIRC8	LOC101747587	ENSGALP00000073811	ENSGALP00000053353	Inhibitor of apoptosis protein 3.	Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...]	0.684
BIRC8	LOC107051192	ENSGALP00000073811	ENSGALP00000059718	Inhibitor of apoptosis protein 3.	RanBP2-type domain-containing protein.	0.924
BIRC8	OTUD7B	ENSGALP00000073811	ENSGALP00000021745	Inhibitor of apoptosis protein 3.	OTU deubiquitinase 7B.	0.433
BIRC8	RIPK1	ENSGALP00000073811	ENSGALP00000036418	Inhibitor of apoptosis protein 3.	Uncharacterized protein.	0.959
BIRC8	RPS27A	ENSGALP00000073811	ENSGALP00000050085	Inhibitor of apoptosis protein 3.	Ubiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...]	0.748
BIRC8	SPATA2	ENSGALP00000073811	ENSGALP00000013007	Inhibitor of apoptosis protein 3.	Uncharacterized protein.	0.511
BIRC8	TAX1BP1	ENSGALP00000073811	ENSGALP00000051712	Inhibitor of apoptosis protein 3.	Uncharacterized protein.	0.574
BIRC8	TBK1	ENSGALP00000073811	ENSGALP00000015982	Inhibitor of apoptosis protein 3.	Protein kinase domain-containing protein.	0.660
BIRC8	TNFAIP3	ENSGALP00000073811	ENSGALP00000046998	Inhibitor of apoptosis protein 3.	TNF alpha induced protein 3.	0.652
BIRC8	TRADD	ENSGALP00000073811	ENSGALP00000005055	Inhibitor of apoptosis protein 3.	TNFRSF1A associated via death domain.	0.863
BIRC8	TRAF1	ENSGALP00000073811	ENSGALP00000002401	Inhibitor of apoptosis protein 3.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.863
BIRC8	TRAF2	ENSGALP00000073811	ENSGALP00000070161	Inhibitor of apoptosis protein 3.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.960
BIRC8	USP4	ENSGALP00000073811	ENSGALP00000006016	Inhibitor of apoptosis protein 3.	Ubiquitin carboxyl-terminal hydrolase.	0.437
CASP3	BIRC8	ENSGALP00000068843	ENSGALP00000073811	Caspase-3; Belongs to the peptidase C14A family.	Inhibitor of apoptosis protein 3.	0.999
CASP3	CASP8	ENSGALP00000068843	ENSGALP00000013591	Caspase-3; Belongs to the peptidase C14A family.	Uncharacterized protein; Belongs to the peptidase C14A family.	0.968