STRINGSTRING
PSMF1 PSMF1 PSMD7 PSMD7 PSMB7 PSMB7 PSMB3 PSMB3 PSMD5 PSMD5 VCP VCP CDC73 CDC73 NOTUM NOTUM PSMA4 PSMA4 SMURF2 SMURF2 PSMD9 PSMD9 SMURF1 SMURF1 CUL3 CUL3 LOC425049 LOC425049 PSMD2 PSMD2 SKP1 SKP1 KIF3A KIF3A PRKAR2A PRKAR2A TUBB1 TUBB1 PRKAR2B PRKAR2B SUFU SUFU ERLEC1 ERLEC1 IFT122 IFT122 IFT140 IFT140 HHAT HHAT PSMA6 PSMA6 SEL1L SEL1L PSMD14 PSMD14 PSMB1 PSMB1 IHH IHH RBX1 RBX1 PSMA3 PSMA3 TUBB2B TUBB2B ADCY2 ADCY2 EVC EVC GPR161 GPR161 IFT57 IFT57 IFT172 IFT172 ADCY3 ADCY3 DZIP1 DZIP1 IFT88 IFT88 PSMB4 PSMB4 PRKAR1A PRKAR1A WDR35 WDR35 EVC2 EVC2 TTC21B TTC21B PSMC3 PSMC3 PSMD11 PSMD11 PSMD12 PSMD12 PRKACB PRKACB PSMB2 PSMB2 PSMD4 PSMD4 NUMB NUMB SPOP SPOP IFT52 IFT52 GRK2 GRK2 TUBA1A TUBA1A CDON CDON LOC100857858 LOC100857858 GPC5 GPC5 PSMA5 PSMA5 ADCY6-2 ADCY6-2 TUBA1B TUBA1B CUL1 CUL1 PSMD3 PSMD3 RPS27A RPS27A PRKAR1B PRKAR1B HHIP HHIP PSMA2 PSMA2 LOC101747587 LOC101747587 DHH DHH ADCY1 ADCY1 ADCY8 ADCY8 PSMD13 PSMD13 ITCH ITCH TUBB6 TUBB6 DERL2 DERL2 PSMC2 PSMC2 PSMB6 PSMB6 PSME3 PSME3 MKS1 MKS1 PSMC6 PSMC6 CSNK1A1 CSNK1A1 GSK3B GSK3B SPOPL SPOPL KIF7 KIF7 PSMD6 PSMD6 ADCY7 ADCY7 RPGRIP1L RPGRIP1L PSMC5 PSMC5 ADCY6 ADCY6 TULP3 TULP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMF1Uncharacterized protein. (271 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMD5Uncharacterized protein. (457 aa)
VCPValosin containing protein. (806 aa)
CDC73Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). (531 aa)
NOTUMNotum, palmitoleoyl-protein carboxylesterase. (496 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (717 aa)
PSMD9PDZ domain-containing protein. (207 aa)
SMURF1E3 ubiquitin-protein ligase. (744 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
LOC425049Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (450 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
SKP1S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1 (By similarity). (163 aa)
KIF3AKinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (706 aa)
PRKAR2AProtein kinase cAMP-dependent type II regulatory subunit alpha. (400 aa)
TUBB1Tubulin beta-6 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (446 aa)
PRKAR2BProtein kinase cAMP-dependent type II regulatory subunit beta. (415 aa)
SUFUSuppressor of fused homolog. (484 aa)
ERLEC1Endoplasmic reticulum lectin 1. (452 aa)
IFT122Intraflagellar transport 122. (1252 aa)
IFT140WD_REPEATS_REGION domain-containing protein. (1453 aa)
HHATHedgehog acyltransferase; Belongs to the membrane-bound acyltransferase family. (481 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
SEL1LSEL1L adaptor subunit of ERAD E3 ubiquitin ligase. (791 aa)
PSMD14MPN domain-containing protein. (310 aa)
PSMB1Proteasome subunit beta. (237 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
RBX1RING-type domain-containing protein. (108 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
TUBB2BTubulin beta-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain; Belongs to the tubulin family. (445 aa)
ADCY2Adenylate cyclase type 2; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1101 aa)
EVCUncharacterized protein. (984 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (535 aa)
IFT57Intraflagellar transport 57. (532 aa)
IFT172Intraflagellar transport 172. (1749 aa)
ADCY3Adenylate cyclase type 3; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1127 aa)
DZIP1DAZ interacting zinc finger protein 1. (833 aa)
IFT88Intraflagellar transport 88. (817 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (258 aa)
PRKAR1AcAMP-dependent protein kinase type I-alpha regulatory subunit. (382 aa)
WDR35WD repeat-containing protein 35. (1178 aa)
EVC2Uncharacterized protein. (1310 aa)
TTC21BTetratricopeptide repeat domain 21B. (1411 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (422 aa)
PSMD11PCI domain-containing protein. (422 aa)
PSMD12PCI domain-containing protein. (456 aa)
PRKACBUncharacterized protein; Belongs to the protein kinase superfamily. (398 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD4VWFA domain-containing protein. (376 aa)
NUMBPID domain-containing protein. (620 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
IFT52Uncharacterized protein. (489 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
TUBA1ATubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (451 aa)
CDONCell adhesion associated, oncogene regulated. (1117 aa)
LOC100857858Tubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (448 aa)
GPC5Glypican 5; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (624 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
ADCY6-2Adenylate cyclase type 5; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1217 aa)
TUBA1BTubulin alpha chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (466 aa)
CUL1Cullin 1; Belongs to the cullin family. (776 aa)
PSMD3PCI domain-containing protein. (602 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
PRKAR1BProtein kinase cAMP-dependent type I regulatory subunit beta. (422 aa)
HHIPHedgehog interacting protein. (697 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
LOC101747587Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1098 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1240 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (376 aa)
ITCHE3 ubiquitin-protein ligase. (878 aa)
TUBB6Tubulin beta-5 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. (446 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
PSMB6Proteasome subunit beta. (204 aa)
PSME3Proteasome activator complex subunit 3; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (421 aa)
MKS1MKS transition zone complex subunit 1. (562 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (431 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly. (370 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (420 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1464 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (400 aa)
ADCY7Adenylate cyclase type 7; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1082 aa)
RPGRIP1LRPGRIP1 like. (1273 aa)
PSMC5AAA domain-containing protein; Belongs to the AAA ATPase family. (427 aa)
ADCY6Adenylate cyclase type 6; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1132 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (465 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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