STRINGSTRING
PSMF1 PSMF1 PSMD7 PSMD7 PSMB7 PSMB7 PSMB3 PSMB3 PSMD5 PSMD5 CDC73 CDC73 PSMA4 PSMA4 SMURF2 SMURF2 PSMD9 PSMD9 SMURF1 SMURF1 CUL3 CUL3 PSMD2 PSMD2 SUFU SUFU PSMA6 PSMA6 PSMD14 PSMD14 PSMB1 PSMB1 IHH IHH RBX1 RBX1 PSMA3 PSMA3 EVC EVC GPR161 GPR161 DZIP1 DZIP1 PSMB4 PSMB4 EVC2 EVC2 PSMC3 PSMC3 PSMD11 PSMD11 PSMD12 PSMD12 PSMB2 PSMB2 PSMD4 PSMD4 NUMB NUMB SPOP SPOP GRK2 GRK2 CDON CDON PSMA5 PSMA5 PSMD3 PSMD3 RPS27A RPS27A HHIP HHIP PSMA2 PSMA2 LOC101747587 LOC101747587 DHH DHH PSMD13 PSMD13 ITCH ITCH PSMC2 PSMC2 PSMB6 PSMB6 PSME3 PSME3 PSMC6 PSMC6 CSNK1A1 CSNK1A1 SPOPL SPOPL KIF7 KIF7 PSMD6 PSMD6 PSMC5 PSMC5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PSMF1Uncharacterized protein. (271 aa)
PSMD7Proteasome 26S subunit, non-ATPase 7. (322 aa)
PSMB7Proteasome subunit beta. (277 aa)
PSMB3Proteasome subunit beta. (205 aa)
PSMD5Uncharacterized protein. (457 aa)
CDC73Parafibromin; Tumor suppressor probably involved in transcriptional and post-transcriptional control pathways. May be involved in cell cycle progression through the regulation of cyclin D1/PRAD1 expression. Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II. PAF1C associates with RNA polymerase II, is involved in transcriptional elongation and in histone modifications including methylation on histone H3 'Lys-4' (H3K4me3) (By similarity). (531 aa)
PSMA4Proteasome subunit alpha type. (261 aa)
SMURF2SMAD specific E3 ubiquitin protein ligase 2. (717 aa)
PSMD9PDZ domain-containing protein. (207 aa)
SMURF1E3 ubiquitin-protein ligase. (744 aa)
CUL3Cullin 3; Belongs to the cullin family. (768 aa)
PSMD226S proteasome non-ATPase regulatory subunit 2; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S2 family. (908 aa)
SUFUSuppressor of fused homolog. (484 aa)
PSMA6Proteasome subunit alpha type. (246 aa)
PSMD14MPN domain-containing protein. (310 aa)
PSMB1Proteasome subunit beta. (237 aa)
IHHIndian hedgehog protein C-product; Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP); Belongs to the hedgehog family. (408 aa)
RBX1RING-type domain-containing protein. (108 aa)
PSMA3Proteasome subunit alpha type. (255 aa)
EVCUncharacterized protein. (984 aa)
GPR161G protein-coupled receptor 161; Belongs to the G-protein coupled receptor 1 family. (535 aa)
DZIP1DAZ interacting zinc finger protein 1. (833 aa)
PSMB4Proteasome subunit beta; Belongs to the peptidase T1B family. (258 aa)
EVC2Uncharacterized protein. (1310 aa)
PSMC3AAA domain-containing protein; Belongs to the AAA ATPase family. (422 aa)
PSMD11PCI domain-containing protein. (422 aa)
PSMD12PCI domain-containing protein. (456 aa)
PSMB2Proteasome subunit beta. (201 aa)
PSMD4VWFA domain-containing protein. (376 aa)
NUMBPID domain-containing protein. (620 aa)
SPOPSpeckle type BTB/POZ protein. (374 aa)
GRK2G protein-coupled receptor kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. (688 aa)
CDONCell adhesion associated, oncogene regulated. (1117 aa)
PSMA5Proteasome subunit alpha type. (241 aa)
PSMD3PCI domain-containing protein. (602 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
HHIPHedgehog interacting protein. (697 aa)
PSMA2Proteasome subunit alpha type. (234 aa)
LOC101747587Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
DHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (411 aa)
PSMD1326S proteasome non-ATPase regulatory subunit 13; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. (376 aa)
ITCHE3 ubiquitin-protein ligase. (878 aa)
PSMC2AAA domain-containing protein; Belongs to the AAA ATPase family. (433 aa)
PSMB6Proteasome subunit beta. (204 aa)
PSME3Proteasome activator complex subunit 3; Implicated in immunoproteasome assembly and required for efficient antigen processing. The PA28 activator complex enhances the generation of class I binding peptides by altering the cleavage pattern of the proteasome (By similarity). (421 aa)
PSMC6AAA domain-containing protein; Belongs to the AAA ATPase family. (431 aa)
CSNK1A1Casein kinase I isoform alpha; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling. May play a role in segregating chromosomes during mitosis. May play a role in keratin cytoskeleton disassembly. (370 aa)
SPOPLSpeckle type BTB/POZ protein like. (392 aa)
KIF7Kinesin family member 7; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (1464 aa)
PSMD6Proteasome 26S subunit, non-ATPase 6. (400 aa)
PSMC5AAA domain-containing protein; Belongs to the AAA ATPase family. (427 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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