STRINGSTRING
RPA2 RPA2 GTF2H2 GTF2H2 ERCC4 ERCC4 RPA1 RPA1 POLE POLE DDB2 DDB2 RPA3 RPA3 RBX1 RBX1 RFC1 RFC1 POLK POLK CUL4A CUL4A ERCC5 ERCC5 RFC3 RFC3 GTF2H3 GTF2H3 POLE3 POLE3 POLE4 POLE4 GTF2H5 GTF2H5 CUL4B CUL4B GTF2H1 GTF2H1 RPS27A RPS27A POLE2 POLE2 RFC2 RFC2 LOC101747587 LOC101747587 RFC5 RFC5 CHD1L CHD1L RFC4 RFC4 PCNA PCNA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RPA2RPA_C domain-containing protein. (267 aa)
GTF2H2General transcription factor IIH subunit. (395 aa)
ERCC4ERCC4 domain-containing protein. (903 aa)
RPA1Replication protein A 70 kDa DNA-binding subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (614 aa)
POLEDNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2290 aa)
DDB2DNA damage-binding protein 2; Required for DNA repair. Binds to DDB1 to form the UV-damaged DNA-binding protein complex (the UV-DDB complex). The UV-DDB complex may recognize UV-induced DNA damage and recruit proteins of the nucleotide excision repair pathway (the NER pathway) to initiate DNA repair. Also appears to function as the substrate recognition module for the DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1- CUL4-ROC1 (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1- CUL4-ROC1 complex may ubiquitinate histone H2A, histone H3 and histone H4 at sites of UV [...] (507 aa)
RPA3Replication protein A3. (121 aa)
RBX1RING-type domain-containing protein. (108 aa)
RFC1Replication factor C subunit 1. (1147 aa)
POLKDNA polymerase kappa. (867 aa)
CUL4ACullin 4A; Belongs to the cullin family. (767 aa)
ERCC5Uncharacterized protein. (1118 aa)
RFC3AAA domain-containing protein. (356 aa)
GTF2H3Uncharacterized protein. (307 aa)
POLE3CBFD_NFYB_HMF domain-containing protein. (143 aa)
POLE4DNA polymerase epsilon 4, accessory subunit. (146 aa)
GTF2H5General transcription factor IIH subunit 5; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFII [...] (71 aa)
CUL4BCullin 4B; Belongs to the cullin family. (883 aa)
GTF2H1Uncharacterized protein. (548 aa)
RPS27AUbiquitin-40S ribosomal protein S27a; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be invo [...] (156 aa)
POLE2DNA polymerase epsilon subunit 2; Accessory component of the DNA polymerase epsilon complex (By similarity). Participates in DNA repair and in chromosomal DNA replication (By similarity). (555 aa)
RFC2Replication factor C subunit 2; The elongation of primed DNA templates by DNA polymerase delta and epsilon requires the action of the accessory proteins proliferating cell nuclear antigen (PCNA) and activator 1. This subunit binds ATP (By similarity). (359 aa)
LOC101747587Polyubiquitin-B; Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; L [...] (305 aa)
RFC5Replication factor C subunit 5. (392 aa)
CHD1LChromodomain helicase DNA binding protein 1 like. (897 aa)
RFC4AAA domain-containing protein. (362 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
Your Current Organism:
Gallus gallus
NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl
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