(27 nodes) TP53 Regulates Transcription of Cell Cycle Genes network (Gallus gallus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

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Your Input:
	CNOT1	Uncharacterized protein. (2376 aa)
	CNOT2	NOT2_3_5 domain-containing protein. (520 aa)
	CNOT6L	CCR4-NOT transcription complex subunit 6 like. (607 aa)
	CNOT10	CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity). (744 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...] (285 aa)
	PLK2	Serine/threonine-protein kinase PLK. (671 aa)
	CCNA1	Cyclin A1; Belongs to the cyclin family. (406 aa)
	CENPJ	Centromere protein J. (1260 aa)
	AURKA	Aurora kinase A; Belongs to the protein kinase superfamily. (409 aa)
	CDKN1B	Cyclin-dependent kinase inhibitor p27 Kip1. (198 aa)
	CNOT4	Uncharacterized protein. (856 aa)
	SFN	14_3_3 domain-containing protein; Belongs to the 14-3-3 family. (246 aa)
	GADD45A	Growth arrest and DNA-damage-inducible protein 45 alpha. (157 aa)
	CCNE2	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family. (405 aa)
	CNOT6	CCR4-NOT transcription complex subunit 6. (557 aa)
	PLK3	Serine/threonine-protein kinase PLK. (644 aa)
	E2F7	E2F transcription factor 7. (923 aa)
	CNOT11	CCR4-NOT transcription complex subunit 11. (473 aa)
	E2F8	E2F transcription factor 8. (738 aa)
	CDK2	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
	CNOT9	Uncharacterized protein. (299 aa)
	CDC25A	Rhodanese domain-containing protein. (526 aa)
	CNOT8	Uncharacterized protein. (292 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (262 aa)
	TNKS1BP1	Tankyrase 1 binding protein 1. (1669 aa)
	CDKN1A	Uncharacterized protein. (319 aa)
	BTG2	BTG anti-proliferation factor 2. (164 aa)

Your Current Organism:

Gallus gallus

NCBI taxonomy Id: 9031
Other names: G. gallus, Gallus domesticus, Gallus gallus domesticus, bantam, chicken, chickens, dwarf Leghorn chickens, red junglefowl

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AURKA	CCNA1	ENSGALP00000032883	ENSGALP00000027497	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin A1; Belongs to the cyclin family.	0.735
AURKA	CCNE2	ENSGALP00000032883	ENSGALP00000043603	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin N-terminal domain-containing protein; Belongs to the cyclin family.	0.509
AURKA	CDK2	ENSGALP00000032883	ENSGALP00000056613	Aurora kinase A; Belongs to the protein kinase superfamily.	Cyclin dependent kinase 2; Belongs to the protein kinase superfamily.	0.632
AURKA	CENPJ	ENSGALP00000032883	ENSGALP00000027640	Aurora kinase A; Belongs to the protein kinase superfamily.	Centromere protein J.	0.716
AURKA	E2F8	ENSGALP00000032883	ENSGALP00000055120	Aurora kinase A; Belongs to the protein kinase superfamily.	E2F transcription factor 8.	0.439
AURKA	GADD45A	ENSGALP00000032883	ENSGALP00000041380	Aurora kinase A; Belongs to the protein kinase superfamily.	Growth arrest and DNA-damage-inducible protein 45 alpha.	0.900
AURKA	PCNA	ENSGALP00000032883	ENSGALP00000064149	Aurora kinase A; Belongs to the protein kinase superfamily.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.429
AURKA	PLK2	ENSGALP00000032883	ENSGALP00000023702	Aurora kinase A; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PLK.	0.732
AURKA	PLK3	ENSGALP00000032883	ENSGALP00000047781	Aurora kinase A; Belongs to the protein kinase superfamily.	Serine/threonine-protein kinase PLK.	0.732
BTG2	CNOT1	ENSGALP00000072692	ENSGALP00000003612	BTG anti-proliferation factor 2.	Uncharacterized protein.	0.669
BTG2	CNOT10	ENSGALP00000072692	ENSGALP00000018708	BTG anti-proliferation factor 2.	CCR4-NOT transcription complex subunit 10; Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Is not required for association of CNOT7 to the CCR4-NOT complex (By similarity).	0.595
BTG2	CNOT11	ENSGALP00000072692	ENSGALP00000051345	BTG anti-proliferation factor 2.	CCR4-NOT transcription complex subunit 11.	0.594
BTG2	CNOT2	ENSGALP00000072692	ENSGALP00000016295	BTG anti-proliferation factor 2.	NOT2_3_5 domain-containing protein.	0.565
BTG2	CNOT4	ENSGALP00000072692	ENSGALP00000037377	BTG anti-proliferation factor 2.	Uncharacterized protein.	0.525
BTG2	CNOT6	ENSGALP00000072692	ENSGALP00000046628	BTG anti-proliferation factor 2.	CCR4-NOT transcription complex subunit 6.	0.578
BTG2	CNOT6L	ENSGALP00000072692	ENSGALP00000016801	BTG anti-proliferation factor 2.	CCR4-NOT transcription complex subunit 6 like.	0.592
BTG2	CNOT7	ENSGALP00000072692	ENSGALP00000022159	BTG anti-proliferation factor 2.	CCR4-NOT transcription complex subunit 7; Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA- mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence [...]	0.815
BTG2	CNOT8	ENSGALP00000072692	ENSGALP00000064058	BTG anti-proliferation factor 2.	Uncharacterized protein.	0.700
BTG2	CNOT9	ENSGALP00000072692	ENSGALP00000056889	BTG anti-proliferation factor 2.	Uncharacterized protein.	0.565
BTG2	TNKS1BP1	ENSGALP00000072692	ENSGALP00000066383	BTG anti-proliferation factor 2.	Tankyrase 1 binding protein 1.	0.499